Nootropic & Neuropeptides

Peptides that modulate neurotransmitter systems (BDNF, dopamine, serotonin) or cross the blood-brain barrier to influence cognition, mood, and anxiety.

3 peptides in this class

Dihexa

→

Target: HGF/c-Met agonist

Angiotensin IV-derived research compound studied for synaptogenesis via the HGF/c-Met pathway. Preclinical and in-vitro only — no human trials, and the foundational mechanism papers were retracted in 2025.

Half-life: ~10 hours (oral bioavailability)Dose: 8–45 mg daily oral (research)

Selank

→

Target: GABAergic / tuftsin analog

Selank is a synthetic neuropeptide derived from tuftsin with anxiolytic and nootropic properties. Developed in Russia for anxiety and cognitive enhancement. Studied for mood regulation, memory, and immune modulation without sedative effects.

Half-life: ~30–50 minutes (intranasal)Dose: 500–900 mcg daily intranasal

Semax

→

Target: BDNF expression / melanocortin modulation

Semax is a synthetic peptide derived from ACTH (4-10) with neuroprotective and cognitive-enhancing properties. Developed in Russia for stroke recovery and cognitive disorders. Studied for memory, focus, neuroplasticity, and BDNF stimulation.

Half-life: ~25 minutes (intranasal)Dose: 600–900 mcg daily intranasal

Compare peptides in this class

Side-by-side mechanism, dose, half-life, and best-price vendor for up to three peptides at once.

Open interactive compare →

Other mechanism classes

GLP-1 agonistGH secretagoguetissue repairmitochondrialmelanocortin agonistimmune modulator