Semaglutide vs Tirzepatide vs Retatrutide
Mechanism, receptor target, half-life, dose, and best-price vendor side by side.
Pick 2–3 peptides to compare
3 selected (maximum).
| Field | Semaglutide | Tirzepatide | Retatrutide |
|---|---|---|---|
| Receptor target | GLP-1R | GLP-1R / GIPR dual agonist | GLP-1R / GIPR / glucagon receptor triple agonist |
| Mechanism class | GLP-1 agonist | GLP-1 agonist | GLP-1 agonist |
| Half-life | ~7 days (weekly dosing) | ~5 days (weekly dosing) | ~6–7 days (weekly dosing) |
| Typical dose | 0.25–2.4 mg weekly SC | 2.5–15 mg weekly SC | 2–12 mg weekly SC (trial doses) |
| Sequence length | 31 residues | 39 residues | 39 residues |
| Best-price vendor | Glacier Aminos → $40.49 (15mg) — $2.70/mg | EZ Peptides → $84.00 (60mg) — $1.40/mg | EZ Peptides → $139.00 (48mg) — $2.90/mg |
| See all vendors | /best/semaglutide → | /best/tirzepatide → | /best/retatrutide → |
Dig deeper
Pricing pulls live from our vendor database. Molecular data comes from published peptide literature. For full dosing protocols, side effects, and research citations, open each peptide's individual page.