Mitochondrial Peptides

Peptides encoded in or targeting the mitochondrial genome. Modulate cellular energy production, apoptosis resistance, and mitochondrial membrane integrity — the core machinery of aging.

3 peptides in this class

Humanin

→

Target: FPR2 / FPRL-1 / CNTFR (apoptosis inhibition)

Humanin is a mitochondrial-derived peptide (MDP) with potent cytoprotective and neuroprotective effects. It protects cells from stress-induced death, improves insulin sensitivity, and has anti-inflammatory properties. Studied for Alzheimer's disease, diabetes, and aging-related conditions.

Half-life: ~1 hourDose: 5–10 mg weekly SC (research)

MOTS-C

→

Target: AMPK activation (mitochondrial-derived peptide)

MOTS-C is a mitochondrial-derived peptide that regulates metabolic homeostasis and has exercise-mimetic effects. Studied for improving insulin sensitivity, fat metabolism, and physical performance. Considered a promising target for metabolic diseases and aging.

Half-life: ~1 hour (circulating); longer intracellular effectsDose: 5–10 mg weekly SC

SS-31 (Elamipretide)

→

Target: Cardiolipin (inner mitochondrial membrane)

SS-31 (Elamipretide) is a mitochondria-targeted peptide that concentrates in the inner mitochondrial membrane. Studied for improving mitochondrial function, reducing oxidative stress, and supporting cellular energy production. In clinical trials for mitochondrial diseases and heart failure.

Half-life: ~2 hoursDose: 1–5 mg daily SC

Compare peptides in this class

Side-by-side mechanism, dose, half-life, and best-price vendor for up to three peptides at once.

Open interactive compare →

Other mechanism classes

GLP-1 agonistGH secretagoguetissue repairnootropicmelanocortin agonistimmune modulator