Cagrilintide
A next-gen amylin analog for powerful appetite control and weight loss. Cagrilintide is Novo Nordisk's long-acting amylin analog designed for weight management. Phase 2 trials showed 11.8% body weight loss as monotherapy and up to 17.1% when combined with semaglutide (CagriSema). Works by enhancing satiety and slowing gastric emptying through amylin receptor activation.
Compare Prices🧬Key Characteristics
- Type: Amylin analog(Long-acting via fatty acid acylation.)
- Target: Amylin receptors (CTR/RAMP)(Area postrema & hypothalamus.)
- Dosing: Once weekly(Subcutaneous injection.)
- Key Trial: REDEFINE 1(CagriSema: 22.7% weight loss.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
Cagrilintide Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Amylin Analog — Long-Acting Satiety PeptideReceptor → Satiety Signal → Weight Loss → Outcomes
Amylin Receptors (CTR + RAMP Complex)
Cagrilintide is a long-acting analog of amylin, a hormone co-secreted with insulin from pancreatic beta cells after meals. It activates amylin receptors (calcitonin receptor + RAMP complexes) in the brain's area postrema and nucleus tractus solitarius — regions that control satiety and gastric function.
cAMP Signaling → Central Satiety + Gastric Slowing
Amylin receptor activation triggers cAMP-mediated signaling in brainstem satiety centers, producing powerful fullness signals. Simultaneously slows gastric emptying and suppresses glucagon secretion. The long-acting acylation extends the half-life to allow once-weekly dosing.
Reduced Appetite + Slower Digestion → Caloric Deficit
The combination of central appetite suppression and delayed gastric emptying creates a sustained caloric deficit. Phase 2 trials showed 11.8% body weight loss as monotherapy. The mechanism complements GLP-1 agonists — different receptor, additive effects.
Strong Satiety → Steady Weight Loss → Metabolic Improvements
Reduced hunger and portion sizes within the first week. Steady weight loss over months. When combined with semaglutide (CagriSema), up to 17.1% weight loss — among the highest of any combination therapy. GI side effects (nausea) are common during titration.
What Makes This Peptide Different
Cagrilintide targets the amylin pathway — a completely different satiety mechanismfrom GLP-1 agonists like semaglutide. This is why CagriSema (cagrilintide + semaglutide) produces additive weight loss — two independent appetite-suppressing pathways activated simultaneously. The long-acting acylation allows weekly dosing like semaglutide. Still investigational — not yet FDA-approved.
Dosing Protocol
Weight Loss / Appetite ControlEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why slow titration? Like all satiety peptides, GI side effects (nausea, vomiting) are dose-dependent. Starting low and increasing every 4 weeks minimizes side effects while the body adapts.
Why weekly? The acyl chain modification extends half-life to allow once-weekly subcutaneous injection, similar to semaglutide.
Why combine with semaglutide? Amylin (cagrilintide) and GLP-1 (semaglutide) use different receptors and pathways. CagriSema trials show the combined effect exceeds either alone — true pharmacological synergy.
Cagrilintide Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
10 mg / vial
In-stock offersOut of stock (1)
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorHandling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
How is cagrilintide different from semaglutide?
They target completely different receptors. Semaglutide is a GLP-1 receptor agonist that works primarily in the gut and brain. Cagrilintide is an amylin receptor agonist that signals satiety through the area postrema in the brainstem. Because the mechanisms are independent, combining them (CagriSema) produces additive weight loss — 22.7% in the REDEFINE 1 trial.
What is CagriSema?
CagriSema is Novo Nordisk's combination of cagrilintide 2.4 mg + semaglutide 2.4 mg in a single weekly injection. Phase 3 REDEFINE 1 results showed 22.7% body weight loss at 68 weeks — significantly more than either drug alone. It's expected to be the next major obesity treatment after current GLP-1 treatments.
What are the side effects of cagrilintide?
The most common side effects are gastrointestinal: nausea (43%), diarrhea, vomiting, and constipation. These are typically mild-to-moderate and decrease over time. Dose escalation over 16 weeks (starting at 0.25 mg) helps minimize GI effects. Hypoglycemia is rare when not combined with insulin.
Is cagrilintide FDA-approved?
As of early 2026, cagrilintide is not yet FDA-approved as a standalone drug. CagriSema (cagrilintide + semaglutide) has completed Phase 3 trials and is under regulatory review. Research-grade cagrilintide is available from peptide vendors for investigational use.
How does amylin reduce appetite?
Amylin is co-secreted with insulin from pancreatic beta cells after meals. It activates receptors in the area postrema and hypothalamus to produce satiety, slow gastric emptying, and suppress glucagon. Cagrilintide mimics these effects with a much longer half-life (allowing weekly dosing) thanks to its C18 fatty acid acylation that enables albumin binding.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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