DSIP
A sleep peptide that enhances natural delta wave sleep without sedation or dependence. DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide that promotes slow-wave delta sleep and modulates stress hormone responses. Research shows improved sleep efficiency, reduced sleep latency, and stress-protective effects. Also studied for pain modulation and neuroendocrine regulation.
Compare Prices🧬Key Characteristics
- Length: 9 amino acids(Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu).)
- Target: Multiple systems(Modulates GABA, opioid, and HPA axis.)
- Discovery: 1977(Isolated from rabbit cerebral venous blood.)
- Primary Use: Sleep quality(Promotes delta wave sleep.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
DSIP Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Neuropeptide — Delta Sleep InducerTarget → Neuromodulation → Sleep Enhancement → Outcomes
Multiple CNS Targets (GABAergic, Serotonergic, Opioid Systems)
DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide that modulates multiple neurotransmitter systems simultaneously. It enhances GABAergic signaling, modulates serotonin pathways, and interacts with the opioid system — all converging on sleep promotion and stress reduction.
Multi-System Neuromodulation → Sleep Architecture Enhancement
DSIP promotes slow-wave (delta) sleep by modulating the balance between excitatory and inhibitory neurotransmission. It reduces cortisol and ACTH (stress hormones) while enhancing serotonin-mediated sleep induction. Unlike benzodiazepines, it works with natural sleep architecture rather than overriding it.
Improved Sleep Quality + Stress Hormone Regulation
Enhanced sleep efficiency (more time asleep vs. in bed), reduced sleep latency (faster to fall asleep), and increased slow-wave sleep duration. Simultaneously normalizes stress hormone profiles — reduced cortisol and improved HPA axis regulation. Also studied for pain modulation effects.
Faster Sleep Onset → Deeper Sleep → Refreshed Mornings
Faster time to fall asleep (often noticeable first night). Deeper, more restorative sleep quality. Feeling more refreshed upon waking. Reduced stress and improved stress resilience during the day. Effects build over multi-day protocols. No hangover or grogginess — unlike pharmaceutical sleep aids.
What Makes This Peptide Different
DSIP is unique in enhancing natural sleep architecture rather than sedating. While Selank reduces anxiety (which can help sleep indirectly), DSIP directly promotes delta wave sleep patterns. Its dual sleep + stress-protective profile makes it particularly useful for stress-related insomnia. No dependence or tolerance has been reported in research.
Dosing Protocol
Sleep Quality / Stress ReliefEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why before bed (30-60 min)? DSIP promotes natural sleep onset. Timing it before the desired sleep window allows the peptide to enhance the natural transition into slow-wave sleep.
Why cycling? While no tolerance has been demonstrated, cycling (2-4 weeks on, 1-2 weeks off) is a conservative approach that maintains efficacy and allows assessment of baseline sleep quality improvements.
DSIP Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
5 mg / vial
In-stock offers10 mg / vial
In-stock offersOut of stock (1)
Looking for medical guidance?
Join the waitlist for doctor-guided peptide plans. We'll notify you when telehealth consultations are available in your state.
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorHandling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
How does DSIP improve sleep without causing sedation?
DSIP modulates multiple neuromodulatory systems — including GABAergic, opioidergic, and glutamatergic pathways — to enhance the body's natural sleep architecture rather than override it. Unlike benzodiazepines or Z-drugs that force sedation, DSIP promotes slow-wave (delta) sleep while allowing normal sleep cycling. This means no grogginess, no cognitive impairment, and natural waking.
Can DSIP cause tolerance or dependence?
No tolerance or dependence has been documented in clinical literature. In fact, DSIP has been studied as a potential treatment for opiate and alcohol withdrawal — the opposite of a dependence-forming drug. Most protocols still recommend cycling (2-4 weeks on, 2 weeks off) as a precaution.
What is the best dose and timing for DSIP?
Community protocols typically use 100–300 mcg subcutaneously, administered 30–60 minutes before bed. Most users start at 100 mcg and increase based on response. Some clinical studies used morning IV infusions and still saw delayed sleep benefits, but evening subcutaneous dosing is the standard research approach.
What other benefits does DSIP have beyond sleep?
Research suggests DSIP has stress-protective properties — it reduces cortisol and ACTH levels, improving HPA axis function. It also shows analgesic (pain-reducing) activity through opioid system interactions, antioxidant effects, and potential benefits for substance withdrawal. Some studies found it normalizes blood pressure and improves heart rate variability.
Can DSIP be stacked with other sleep peptides?
Common stacks include DSIP with Selank (for anxiolytic support if stress contributes to insomnia), Epitalon (for melatonin regulation and telomere benefits), or low-dose Ipamorelin (for synergistic GH release during deep sleep). Each peptide should be injected at a separate site. Avoid combining with pharmaceutical sedatives.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.
Disclosure: we may earn affiliate commission from qualifying purchases. Educational information only — not medical advice.