Selank Dosing: 1mg SubQ, 2-3x/Week Protocol

Selank (TP-7) is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, approved in Russia as a nasal spray for anxiety and neurasthenia. It has genuine human clinical trial data, with efficacy comparable to benzodiazepines but without sedation, tolerance, or dependence.

Selank is not FDA-approved. It has clinical approval in Russia only. This is not medical advice. For a deeper look at how Selank works, see our Selank benefits guide.

Quick Reference: Standard Protocol

For the full Selank peptide profile and vendor pricing, see our Selank peptide page.

Cycling Details

The standard cycle is 1 mg subcutaneous in the morning, 2-3 days per week, for 8 weeks on / 8 weeks off.

Weeks 1-2 (Assessment): Start at 1 mg, 2 days per week. Assess anxiolytic response. Some users notice effects within the first dose; others require several days.

Weeks 3-8 (Maintenance): Continue at 1 mg, 2-3 days per week based on response.

Off-cycle: Selank doesn't show tolerance in clinical studies, but cycling is a conservative approach to maintain receptor sensitivity. Avoid late evening dosing — some users report mild stimulating effects.

Routes of Administration

Intranasal spray is the original and most-studied route — Selank was developed as a nasal formulation. Clinical protocols used 250-300 mcg intranasally, 3 times daily for 14 days.

Subcutaneous injection is the community alternative, offering more consistent absorption. Standard sites: abdomen, love handles. Use 29-31 gauge insulin syringe.

Reconstitution Quick Reference

Math: 30 mg / 3 mL = 10 mg/mL. For 1 mg: 1 / 10 = 0.1 mL = 10 units.

Swirl gently — do not shake. Refrigerate at 2-8 C, use within 28 days.

Where These Numbers Come From

Selank is relatively unique — it has genuine human clinical trial data and regulatory approval in Russia.

Generalized Anxiety Disorder: Selank was compared to the benzodiazepine medazepam in GAD patients and showed comparable anxiolytic effects with additional antiasthenic and psychostimulant properties (Zozulya et al., 2008).

Enkephalinase inhibition: Selank potently inhibits enkephalin-degrading enzymes, increasing endogenous enkephalin levels and modulating the opioid system (Kost et al., 2001).

GABAergic modulation: Affects expression of genes involved in GABA neurotransmission, providing benzodiazepine-like effects through a different mechanism (Kasian et al., 2016).

BDNF regulation: Intranasal Selank regulates BDNF expression in the hippocampus, linking anxiolytic and neurotrophic effects (Inozemtseva et al., 2008).

Stacking Protocols

Start each peptide separately to assess individual response. If using multiple nasal sprays, space 10-15 minutes apart.

Side Effects & Safety

• No sedation — unlike benzodiazepines, does not cause drowsiness or cognitive impairment
• No tolerance or dependence — confirmed in clinical evaluations
• Mild nasal irritation with intranasal use
• Occasional headache — typically first 1-2 days
• Mild fatigue or lightheadedness at higher doses (uncommon)
• Injection site irritation — minor, SC route
• Contraindications: Pregnancy/breastfeeding (no safety data), active infections (immunomodulatory effects warrant caution)

Frequently Asked Questions

What is the standard Selank dose?

1 mg subcutaneous in the morning, 2-3 days per week. Reconstitute a 30 mg vial with 3 mL BAC water (10 mg/mL) and draw 10 units per dose. Cycle 8 weeks on / 8 weeks off.

Is Selank better as a nasal spray or injection?

Nasal spray is the original and most-studied route. Subcutaneous injection is a community alternative offering potentially more consistent absorption.

How long should a Selank cycle last?

8 weeks on, 8 weeks off. This maintains receptor sensitivity and aligns with standard nootropic peptide cycling protocols.

Does Selank cause dependence like benzodiazepines?

No. Selank does not cause tolerance, dependence, or withdrawal. Clinical studies confirmed anxiolytic effects comparable to benzodiazepines without sedation or addiction potential.

Can Selank be stacked with Semax?

Yes — this is a classic Russian nootropic stack. Selank provides anxiolytic and calming effects while Semax adds cognitive stimulation and BDNF upregulation.

How quickly does Selank work?

Many users report effects within minutes to hours of intranasal administration. Full benefits develop over 7-14 days of consistent dosing.

Related Guides

• Selank Benefits — 6 effects on anxiety and focus ranked by evidence
• Selank Results Timeline — Week-by-week expectations from day 1 through month 2
• Selank vs Semax — Which nootropic peptide fits your goals
• Semax Dosing Guide — Cognitive enhancement peptide for stacking
• DSIP Dosing Guide — Sleep peptide that pairs well with Selank
• BPC-157 Dosing Guide — Gut-brain axis peptide for neurological stacking
• Peptide Stacking Guide — Principles for combining Selank with other peptides
• Calculate Your Selank Cycle Cost — estimate vials needed and total cost for your protocol

References

For educational and research purposes only. This is not medical advice. Selank has clinical approval in Russia but is not FDA-approved.