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BPC-157

A healing peptide for tendons, joints, gut issues, and injury recovery. BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protein found in gastric juice. Studied extensively for tissue repair, wound healing, and anti-inflammatory effects. Popular in research for tendon, ligament, muscle, and gut healing applications.

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🧬Key Characteristics
  • Length: 15 amino acids
    (Pentadecapeptide structure.)
  • Origin: Gastric juice
    (Derived from human body protection compound.)
  • Stability: High
    (Stable in gastric acid, can be taken orally or injected.)
  • Primary Use: Tissue repair
    (Tendons, ligaments, muscles, gut healing.)
Peptide sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
The sequence is a partial fragment of the larger body protection compound (BPC) found in gastric juice. This 15-amino acid fragment retains the healing properties of the parent compound.
Key takeaway: BPC-157 is one of the most studied peptides for tissue repair and healing. It works through multiple mechanisms including angiogenesis, growth factor modulation, and nitric oxide pathways. Often stacked with TB-500 or Thymosin Beta-4 for synergistic healing — BPC-157 for local repair, TB-500/TB-4 for systemic regeneration.

Overview

Core Benefits

Key Advantages
Tissue repair
Studied for accelerating healing of tendons, ligaments, muscles, and other tissues.
Anti-inflammatory
May help reduce inflammation at injury sites and throughout the body.
Wound healing
Research shows potential for faster wound closure and tissue regeneration.
Gut health
Some healing peptides show benefits for gut lining and digestive health.
Joint support
May support joint comfort and mobility during recovery.
Synergistic stacking
Often combined with other healing peptides for comprehensive recovery.

These are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.

BPC-157 Results Timeline

Progression
1
Week 1–2
Physical Changes
Initial inflammatory response modulation, early tissue repair signals
Performance & Recovery
May notice reduced discomfort at injury sites
Other Benefits
Improved gut comfort (if applicable), better sleep quality
2
Week 3–4
Physical Changes
Visible improvement in healing tissues, reduced swelling
Performance & Recovery
Increased mobility and flexibility in affected areas
Other Benefits
Enhanced recovery from workouts, improved overall well-being
3
Month 2–3
Physical Changes
Significant tissue repair progress, improved joint comfort
Performance & Recovery
Return to normal activity levels, reduced pain
Other Benefits
Systemic healing benefits, improved skin quality
4
3+ Months
Physical Changes
Near-complete healing of targeted tissues
Performance & Recovery
Full functional recovery in many cases
Other Benefits
Cumulative benefits build over multiple 8-week on/off cycles; many see best results with 2-3 cycles

Timeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.

How It Works

Healing Peptide — Gastric Pentadecapeptide

Target → Multi-Pathway Repair → Tissue Healing → Outcomes

🎯
Target

Multiple: VEGFR2, PDGFR, Nitric Oxide System

BPC-157 is derived from a protein in gastric juice and interacts with multiple signaling systems simultaneously — growth factor receptors (VEGF, PDGF), nitric oxide pathways, and the FAK-paxillin pathway involved in cell migration and tissue repair.

Cellular Signal

Angiogenesis + Cell Migration + Anti-Inflammatory

Upregulates VEGF (new blood vessel formation), activates growth factor receptor signaling for tissue repair, modulates nitric oxide for blood flow, and reduces inflammatory cytokines. This multi-pathway action is why BPC-157 affects so many tissue types.

🔄
Systemic Effect

Accelerated Tissue Repair Across Multiple Systems

Enhanced healing of tendons, ligaments, muscles, gut lining, and other tissues. Improved blood flow to injured areas via angiogenesis. Anti-inflammatory effects reduce swelling and pain at injury sites. Gut-protective effects support digestive health.

What You Notice

Reduced Pain → Faster Healing → Gut Comfort

Reduced pain and inflammation at injury sites within days to weeks. Accelerated healing timelines for injuries. Improved gut comfort (if GI issues present). Often stacked with TB-500 for comprehensive healing via complementary mechanisms.

What Makes This Peptide Different

BPC-157 is unique among healing peptides for its multi-system action — it affects tendons, ligaments, muscles, gut, and even brain tissue through multiple signaling pathways. While TB-500 works primarily through actin regulation and systemic distribution, BPC-157 works through growth factor upregulation and angiogenesis. This is why the two are commonly stacked — different mechanisms, complementary healing effects.

Dosing Protocol

Healing / Tissue Repair

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
500 mcg (10 units on 1ml syringe)
Timing
AM and/or PM
Frequency
Every day
Duration
8 weeks on, 8 weeks off
Protocol Notes
Can inject subcutaneously near injury site or systemically. Often stacked with TB-500 for synergy.
Read the full dosing guide — protocols, reconstitution, clinical context & more

Popular Stack Protocols

3 stacks

Commonly paired protocols from the peptide research community. Educational reference only.

🧬 BPC-157 + TB-500

Healing / Injury Recovery
Dose
500 mcg
Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
500 mcg
Vial Size
10 mg
Reconstitution
2 ml BAC water
Timing
AM (can split AM/PM)
Frequency
Daily
Duration
8 weeks on, 8 weeks off
The gold standard healing stack. BPC-157 drives local angiogenesis and growth factor upregulation while TB-500 provides systemic tissue repair via actin sequestration and cell migration. Complementary, non-overlapping mechanisms. BPC-157 can be injected near injury site; TB-500 works systemically regardless of injection site.

🧬 BPC-157 + TB-4 (Full-Length)

Healing / Tissue Repair
Dose
500 mcg
Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
500 mcg – 1 mg
Vial Size
5 mg
Reconstitution
2 ml BAC water
Timing
AM (can split AM/PM)
Frequency
TB-4: daily loading (2 weeks), then 2x/week. BPC-157: daily throughout.
Duration
4–8 weeks
Full-length TB-4 includes the TB-500 active fragment plus additional sequences that activate cardiac progenitor cells and hair follicle stem cells. More comprehensive healing than the TB-500 variant. Loading phase for TB-4 is important to saturate tissue levels before tapering to maintenance.

🧬 BPC-157 + GHK-Cu

Healing / Skin / Tissue Repair
Dose
500 mcg
Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
1–2 mg
Vial Size
50 mg
Reconstitution
3 ml BAC water
Timing
AM
Frequency
Daily
Duration
8 weeks on, 8 weeks off
BPC-157 handles deep tissue repair (tendons, gut, vasculature) while GHK-Cu excels at skin remodeling, collagen synthesis, and wound healing. GHK-Cu also activates genes involved in tissue remodeling that BPC-157 doesn't directly target. Complementary for post-surgical or injury recovery with a skin/cosmetic component.

Why This Dosing Protocol

Why inject near the injury? While BPC-157 has systemic effects, local injection near the injury site provides higher local concentrations for targeted repair. Subcutaneous injection near the area is sufficient — intramuscular into the exact injury isn't necessary.

Why twice daily? BPC-157's relatively short half-life benefits from split dosing (AM/PM) to maintain more consistent tissue levels during the healing window.

Why stack with TB-500? BPC-157 (angiogenesis + growth factors) and TB-500 (actin regulation + systemic distribution) use different mechanisms. Together they provide comprehensive healing support.

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Stacks

BPC-157 is commonly paired with ipamorelin in GH-axis research discussions. For comparing bundles fairly, we normalize stack value using the BPC-157 amount as the driving peptide (assuming ratios remain consistent as bundle sizes scale).

BPC-157 + TB-500

Sorted by cost per mg of CJC. COA = Certificate of Analysis (vendor-provided lab documentation).
VendorStackPrice$/mg (CJC)COALink
Certified Pep10mg/10mg$110.00$11.00Go →
EZ Peptides5mg/5mg$60.00$12.00Go →

BPC-157 + Thymosin Beta-4

Sorted by cost per mg of CJC. COA = Certificate of Analysis (vendor-provided lab documentation).
VendorStackPrice$/mg (CJC)COALink
EZ Peptides5mg/5mg$48.00$9.60Go →

BPC-157 + GHK-Cu + TB-500

Glow Stack

Sorted by cost per mg of CJC. COA = Certificate of Analysis (vendor-provided lab documentation).
VendorStackPrice$/mg (CJC)COALink
Certified Pep80mg$158.00$1.98Go →

Reconstitution calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Educational Videos

How to Reconstitute BPC-157 Peptide and Calculate Dosage

Injecting BPC-157 for a shoulder injury

BPC-157 Benefits and Risks

What is BPC-157?

Handling

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder Storage (Very Stable)
  • Freezer (-20°C): 1+ year ✓
  • Refrigerator (2-8°C): 1-3 months ✓
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted Storage (Fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

Storage & Handling Guide

Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

FAQ

What is BPC-157 used for?

BPC-157 is studied primarily for tissue healing and repair. Research focuses on tendon, ligament, muscle, and gut healing. It's popular in sports medicine research for injury recovery and is often discussed for healing joints, reducing inflammation, and gut health support.

How does BPC-157 work?

BPC-157 appears to work through multiple mechanisms: promoting angiogenesis (new blood vessel formation), modulating growth factors, reducing inflammation, and protecting cells from oxidative stress. It may also influence nitric oxide pathways and help regulate the gut-brain axis.

Is BPC-157 often combined with other peptides?

Yes, BPC-157 is frequently discussed alongside TB-500 (Thymosin Beta-4) for synergistic healing effects. The combination is popular in research for comprehensive tissue repair, with BPC-157 focusing on localized healing and TB-500 on systemic tissue repair.

What is BPC-157?

BPC-157 (Body Protection Compound-157) is a synthetic peptide derived from a protein found in human gastric juice. It's a 15-amino acid sequence that has shown remarkable healing properties in research. "BPC" refers to its protective effects observed in gastrointestinal studies.

What is the typical BPC-157 dosage?

A common research dosage is 500 mcg per day (10 units on 1ml syringe), administered AM and/or PM. It can be injected subcutaneously near the injury site or systemically. Protocol: every day, 8 weeks on, 8 weeks off. Often stacked with TB-500 for synergy.

Can BPC-157 help with gut issues?

Yes, BPC-157 has shown promise for various gut conditions in research, including inflammatory bowel disease, ulcers, and leaky gut. It appears to protect and heal the gut lining, reduce inflammation, and support the gut-brain axis. This aligns with its origin in gastric juice.

How long does BPC-157 take to work?

Some users report improvements within days for minor issues, but significant healing typically takes 2-4 weeks. Chronic or severe injuries may require 4-8 weeks or longer. Consistency is important — healing is a gradual process that BPC-157 supports rather than instantly fixes.

What are the side effects of BPC-157?

BPC-157 is generally well-tolerated with minimal reported side effects. Some users experience mild nausea, dizziness, or headache. Injection site reactions may occur. Long-term safety data in humans is limited. There are theoretical concerns about effects on cancer growth, though not demonstrated in studies.

How long does reconstituted peptide last?

Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.

Is this peptide legal to purchase?

Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.

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Scientific Sources

The following peer-reviewed studies and official resources provide additional scientific context for this peptide:

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