Thymosin Beta-4
A full-spectrum healing peptide for tissue repair, cardiac support, and hair growth. Thymosin Beta-4 (TB-4) is the full-length 43 amino acid peptide naturally found in human tissues, particularly the thymus gland. It plays a crucial role in tissue repair, wound healing, cell migration, angiogenesis, and immune regulation. More biologically complete than TB-500, it interacts with multiple pathways for superior regenerative effects. Often stacked with BPC-157 for comprehensive healing.
Compare Prices🧬Key Characteristics
- Length: 43 amino acids(Full-length native peptide.)
- Origin: Thymus gland(Naturally produced in many tissues.)
- Mechanism: Multi-pathway(Actin binding, angiogenesis, immune modulation.)
- vs TB-500: More complete(Full bioactivity vs fragment.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
Thymosin Beta-4 Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Healing Peptide — Full-Length Thymosin Beta-4Target → Repair Signal → Tissue Healing → Outcomes
G-Actin (Cytoskeletal Protein) — Full Molecule
Thymosin Beta-4 is the full 43-amino-acid protein from which TB-500 is derived. It contains the same actin-binding domain plus additional sequences that may provide broader biological activity, including immune modulation and cardiac repair.
Actin Regulation + Extended Signaling Domains
Same core actin-sequestering mechanism as TB-500, but the full-length molecule provides additional signaling capabilities. The extra amino acid sequences interact with more cellular pathways, potentially offering more comprehensive healing and immune effects.
Comprehensive Healing + Immune + Cardiac Support
Tissue repair, anti-inflammation, and cell migration (like TB-500), plus enhanced immune modulation and cardioprotective effects from the additional protein domains. Research shows particular promise for cardiac tissue repair after injury.
Similar to TB-500 with Broader Effects
Healing and anti-inflammatory effects similar to TB-500. Some users report more comprehensive results, particularly for complex or multi-system injuries. Often chosen when maximum healing support is desired. Stacks well with BPC-157.
What Makes This Peptide Different
Thymosin Beta-4 is the full-length parent molecule of TB-500. While TB-500 contains the key actin-binding fragment, Thymosin Beta-4 includes additional sequences that may provide broader healing, immune, and cardioprotective effects. The tradeoff: higher cost and potentially less targeted action compared to TB-500's focused fragment.
Dosing Protocol
Healing / Tissue RepairEducational reference only. Individual responses vary. Consult healthcare provider before use.
Popular Stack Protocols
1 stackCommonly paired protocols from the peptide research community. Educational reference only.
🧬 BPC-157 + TB-4 (Full-Length)
Healing / Tissue RepairWhy This Dosing Protocol
Why same protocol as TB-500? Both work through actin regulation with systemic distribution. Loading phase (daily 2-4 weeks) followed by maintenance (2x/week) is the standard approach.
TB-500 vs Thymosin Beta-4: TB-500 is the targeted fragment — sufficient for most healing needs. Full Thymosin Beta-4 is chosen for complex injuries or when maximum healing support is desired.
Diagrams
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Thymosin Beta-4 Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
10 mg / vial
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Stacks
Thymosin Beta-4 is commonly paired with ipamorelin in GH-axis research discussions. For comparing bundles fairly, we normalize stack value using the Thymosin Beta-4 amount as the driving peptide (assuming ratios remain consistent as bundle sizes scale).
BPC-157 + Thymosin Beta-4
| Vendor | Stack | Price | $/mg (CJC) | COA | Link |
|---|---|---|---|---|---|
| EZ Peptides | 5mg/5mg | $48.00 | $9.60 | Go → |
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What is Thymosin Beta-4 and how does it differ from TB-500?
Thymosin Beta-4 (TB-4) is the full-length 43-amino acid peptide naturally found in human tissues. TB-500 is a synthetic fragment of TB-4 designed to be more affordable. TB-4 offers complete biological activity across multiple regenerative pathways, while TB-500 captures only part of that activity. TB-4 is considered more potent but costs more.
Why would someone choose TB-4 over TB-500?
TB-4 is the full-length, biologically complete peptide that interacts with more pathways than the TB-500 fragment. Researchers choose TB-4 when they want maximum regenerative potential and full multi-pathway activity (tissue repair, angiogenesis, immune modulation). TB-500 is chosen when cost is a primary factor.
Is Thymosin Beta-4 commonly stacked with BPC-157?
Yes, the TB-4 + BPC-157 stack is one of the most popular healing combinations in peptide research. BPC-157 provides localized healing at injury sites, while TB-4 provides systemic regeneration throughout the body. Together they're discussed for comprehensive tissue repair, tendon/ligament healing, and faster recovery.
How does Thymosin Beta-4 work?
TB-4 sequesters G-actin, regulating the actin cytoskeleton essential for cell movement. This promotes cell migration to injury sites. It also stimulates angiogenesis, reduces inflammation, has antimicrobial properties, and modulates immune responses. Its multi-pathway activity explains its broad healing capabilities.
What is the typical Thymosin Beta-4 dosage?
A common protocol uses 500 mcg to 1 mg per injection daily during the cycle. Protocol: 8 weeks on, 8 weeks off. As the full-length version of TB-500, TB-4 provides more comprehensive healing effects.
What conditions is Thymosin Beta-4 researched for?
Research areas include wound healing, cardiac repair (post-heart attack), corneal injury, neurological injury, muscle repair, and hair growth. TB-4 has been in clinical trials for wound healing and cardiac conditions. Its broad regenerative effects make it relevant for many tissue repair applications.
Does Thymosin Beta-4 have cardiac benefits?
Yes, TB-4 has shown cardioprotective effects in research. It can activate cardiac progenitor cells, promote new blood vessel formation in the heart, and reduce scarring after heart attacks. Clinical trials have explored its use for cardiac repair, showing promise for improving heart function post-injury.
What are the side effects of Thymosin Beta-4?
TB-4 is generally well-tolerated as it's a naturally occurring peptide. Possible side effects include temporary fatigue, head rush, and injection site reactions. Like other healing peptides, there are theoretical concerns about tumor growth promotion, though research has not confirmed this risk.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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