BPC-157 Dosing: 500mcg/Day Protocol

BPC-157 (Body Protection Compound-157) is a 15-amino-acid synthetic peptide derived from a protein in human gastric juice. It's one of the most researched healing peptides, with hundreds of animal studies on tissue repair, gut healing, tendon recovery, and neuroprotection. No human clinical trials exist. This is not medical advice.

Quick Reference: Standard Protocol

The standard protocol is 500 mcg once daily for 8 weeks, then 8 weeks off. Some users split the dose AM/PM (250 mcg twice daily) for more consistent tissue levels, but the total daily dose stays at 500 mcg.

For the full BPC-157 peptide profile, vendor pricing, and stack protocols, see our BPC-157 peptide page.

Cycling: 8 Weeks On, 8 Weeks Off

Run 500 mcg daily for 8 weeks straight, then 8 weeks off before repeating. This aligns with the tissue repair timeline seen in animal studies -- rapid angiogenesis and growth factor activity in weeks 1-2, followed by remodeling through week 8 (Sikiric et al., 2006).

No loading phase is needed. BPC-157 is dosed every day (no weekly breaks) for the full 8-week cycle.

Routes of Administration

Subcutaneous injection (most common): For localized injuries, inject within a few inches of the injury site. For systemic issues, abdomen or love handle area works. BPC-157 distributes systemically regardless of injection site. Typical volume: 0.1-0.2 mL with a 29-31 gauge insulin syringe.

Oral: BPC-157 is uniquely stable in stomach acid. Oral dosing is viable especially for GI-specific issues -- ulcers, IBD, NSAID-induced gut damage (Sikiric, 1999). Bioavailability is lower than injection, so some protocols use higher oral doses.

Intramuscular: Used when targeting a specific muscle injury -- direct injection into the muscle belly. Less common than SC (Novinscak et al., 2008).

Reconstitution Quick Reference

Math: 10,000 mcg / 2 mL = 5,000 mcg/mL. For 500 mcg: 500 / 5,000 = 0.1 mL = 10 units. One vial lasts 20 days.

Swirl gently -- do not shake. Refrigerate at 2-8°C and use within 28 days. For step-by-step instructions, dilution charts, and storage details, see the full BPC-157 Reconstitution Guide.

Dosing a BPC-157 / TB-500 Blend Vial

Many vendors sell pre-mixed blend vials (e.g., 10 mg BPC-157 + 10 mg TB-500). Both peptides are already combined -- every unit you draw contains equal parts of each.

Reconstitution (10 mg/10 mg blend with 2 mL BAC water -- 5,000 mcg/mL per peptide):

For a 5 mg/5 mg blend with 2 mL BAC water (2,500 mcg/mL per peptide), double the units above for the same dose.

Where These Numbers Come From

The community doses are extrapolated from a large body of animal research.

Animal study doses: Nearly all BPC-157 research uses rats at 10 mcg/kg (the standard research dose), with some studies going up to 50 mcg/kg. This dose has been used across hundreds of studies (Sikiric et al., 2006; Krivic et al., 2006).

Allometric scaling: Using the FDA's standard body surface area conversion (rat dose x 0.162), the human equivalent range is roughly 110-560 mcg/day -- which is where the community's 250-500 mcg/day window comes from.

Wide therapeutic window: Animal studies showed activity even at ultra-low doses (10 ng/kg), suggesting BPC-157 is active across a broad dose range (Krivic et al., 2006).

Stacking Protocols

See our BPC-157 vs TB-500 comparison for a detailed breakdown.

Stacking tips: Inject at separate sites when using multiple peptides. Start one peptide at a time to assess individual response.

Side Effects & Safety

• No lethal dose found -- toxicology studies couldn't establish an LD50 (Sikiric et al., 2006)
• No organ toxicity in chronic dosing
• No hormonal effects -- doesn't affect testosterone, estrogen, cortisol, or GH
• Mild nausea -- mostly with oral dosing
• Brief lightheadedness -- occasionally after injection
• Injection site redness -- standard for SC peptides
• Angiogenesis concern -- promotes new blood vessel growth, which raises a theoretical question about existing tumors. No study has shown BPC-157 promoting tumor growth, but the concern is noted in reviews (Sikiric et al., 2014)
• FDA status -- added to restricted compounding list in 2024; returning to legal compounding in 2026

Frequently Asked Questions

What is the standard BPC-157 dose?

500 mcg per day via subcutaneous injection, dosed AM or PM (or split 250 mcg AM + 250 mcg PM), every day for 8 weeks on / 8 weeks off. Use a 10 mg vial with 2 mL BAC water -- 500 mcg = 10 units.

Can BPC-157 be taken orally?

Yes -- one of the few peptides stable in gastric acid. Especially useful for GI conditions. Bioavailability is lower than injection, so oral protocols sometimes use higher doses or longer cycles.

How long should a BPC-157 cycle last?

8 weeks on, 8 weeks off. This allows the full tissue repair timeline to play out before taking a break.

Should I inject near the injury or anywhere?

Both work. BPC-157 distributes systemically regardless of injection site. For specific injuries, most people inject as close to the site as practical. For gut issues, oral is the more direct route.

Is BPC-157 FDA-approved?

No. BPC-157 has no FDA-approved human indication. In 2024, the FDA added it to the restricted compounding list. It is returning to legal compounding in 2026.

Can BPC-157 and TB-500 be taken together?

Yes -- the most referenced healing stack. Different mechanisms (growth factors vs actin remodeling) make them complementary.

Related Guides

• BPC-157 Peptide Page -- Full profile, vendor pricing, and comparisons
• BPC-157 Reconstitution Guide -- Step-by-step mixing, dilution charts, and storage
• BPC-157 Bloodwork Guide -- What labs to track and optimal ranges
• BPC-157 Benefits & Research -- Deep dive on what the research shows
• BPC-157 Results Timeline -- What to expect week by week
• BPC-157 Clinical Trials -- Current human trial status and FDA pathway
• BPC-157 vs TB-500 -- Head-to-head healing peptide comparison
• Calculate Your BPC-157 Cycle Cost -- estimate vials needed and total cost for your protocol

Available in Blends

• Wolverine Stack Dosing Guide -- BPC-157 + TB-500 (20mg 2-peptide blend)

• Klow Blend Dosing Guide -- BPC-157 + TB-500 + GHK-Cu + KPV (80mg 4-peptide blend)

• Glow Blend Dosing Guide -- BPC-157 + TB-500 + GHK-Cu (70mg 3-peptide blend)

• 14 Peptides Legal Again: FDA Reclassification -- BPC-157 is returning to legal compounding pharmacies in 2026

References

For educational and research purposes only. This is not medical advice. BPC-157 is not FDA-approved for any indication.