TB-500
A tissue repair peptide for flexibility, injury recovery, and systemic healing. TB-500 (Thymosin Beta-4 fragment) is a synthetic peptide that promotes tissue repair, cell migration, and angiogenesis. Researched for wound healing, flexibility, injury recovery, and reducing inflammation. Often discussed alongside BPC-157 for synergistic healing effects.
Compare Prices🧬Key Characteristics
- Length: 43 amino acids(Full Thymosin Beta-4 sequence.)
- Origin: Thymus gland(Naturally produced in many cell types.)
- Mechanism: Actin binding(Promotes cell migration and tissue repair.)
- Primary Use: Systemic healing(Works throughout the body, not just locally.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
TB-500 Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Healing Peptide — Thymosin Beta-4 FragmentTarget → Repair Signal → Tissue Healing → Outcomes
G-Actin (Cytoskeletal Protein)
TB-500 is the active fragment of Thymosin Beta-4. It binds G-actin, a building block of the cell's structural framework. By regulating actin polymerization, TB-500 directly influences cell migration, blood vessel formation, and wound healing at the cellular level.
Actin Sequestration → Cell Migration + Repair
TB-500 sequesters G-actin monomers, promoting cell migration to injury sites and supporting new blood vessel growth. It also reduces inflammation through NF-kB pathway modulation and promotes stem cell maturation for tissue regeneration.
Widespread Tissue Repair + Anti-Inflammation
Unlike locally-acting peptides, TB-500 distributes systemically — injection site doesn't determine where healing occurs. It reduces inflammation body-wide, promotes tissue repair in muscles, tendons, ligaments, skin, and cardiac tissue.
Reduced Inflammation → Faster Healing → Flexibility
Reduced overall inflammation and stiffness within 1-2 weeks. Faster healing of injuries over weeks to months. Improved flexibility and range of motion. Often stacked with BPC-157 for complementary healing via different mechanisms.
What Makes This Peptide Different
TB-500's key advantage is systemic distribution — it doesn't matter where you inject it, the peptide travels throughout the body. This makes it ideal for multiple simultaneous injuries or general inflammation reduction. While BPC-157 works through growth factor pathways (best for targeted local healing), TB-500 works through actin regulation (best for systemic repair). The two use completely different mechanisms, which is why stacking them is so popular.
Dosing Protocol
Healing / Tissue RepairEducational reference only. Individual responses vary. Consult healthcare provider before use.
Popular Stack Protocols
1 stackCommonly paired protocols from the peptide research community. Educational reference only.
🧬 BPC-157 + TB-500
Healing / Injury RecoveryWhy This Dosing Protocol
Why daily dosing? TB-500 benefits from consistent daily dosing to saturate tissues throughout the 8-week cycle (8 weeks on, 8 weeks off). This maximizes the healing response.
Why injection site doesn't matter? TB-500's small molecular weight and actin-binding mechanism allow systemic distribution. Subcutaneous injection anywhere is sufficient — no need to inject near the injury.
Diagrams
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TB-500 Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
5 mg / vial
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10 mg / vial
In-stock offersOut of stock (2)
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Stacks
TB-500 is commonly paired with ipamorelin in GH-axis research discussions. For comparing bundles fairly, we normalize stack value using the TB-500 amount as the driving peptide (assuming ratios remain consistent as bundle sizes scale).
BPC-157 + TB-500
BPC-157 + GHK-Cu + TB-500
Glow Stack
| Vendor | Stack | Price | $/mg (CJC) | COA | Link |
|---|---|---|---|---|---|
| Certified Pep | 80mg | $158.00 | $1.98 | Go → |
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What is TB-500 and how does it differ from BPC-157?
TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring peptide involved in tissue repair. While both promote healing, TB-500 works more systemically (throughout the body) and focuses on cell migration and blood vessel formation, while BPC-157 tends to work more locally at injury sites.
What is TB-500 researched for?
TB-500 is studied for wound healing, tissue repair, flexibility, reducing inflammation, and promoting hair growth. It's popular in research for muscle injuries, tendon repair, and overall recovery from tissue damage.
What's the difference between TB-500 and Thymosin Beta-4?
TB-500 is a synthetic fragment designed to mimic the active region of the full-length Thymosin Beta-4 (TB-4) peptide. TB-4 is the complete 43-amino acid peptide with full biological activity across multiple pathways, while TB-500 is a simplified, more affordable version. TB-4 is considered more potent but costs more.
How does TB-500 work?
TB-500 promotes healing through several mechanisms: upregulating actin (a protein crucial for cell structure and movement), promoting cell migration to injury sites, stimulating angiogenesis (new blood vessel formation), and reducing inflammation. It helps cells move to where they're needed for repair.
What is the typical TB-500 dosage?
A common research dosage is 500 mcg per injection (10 units on 1ml syringe) administered every day in the AM. Protocol: 8 weeks on, 8 weeks off. Injection site doesn't matter as TB-500 has systemic effects throughout the body.
Can TB-500 help with flexibility?
Yes, TB-500 is noted for potentially improving flexibility and reducing muscle stiffness. This may be due to its effects on tissue remodeling and reducing adhesions. Many users report improved range of motion and reduced muscle tightness, especially when recovering from injuries.
Is TB-500 good for hair growth?
Research suggests TB-500 may promote hair growth by stimulating hair follicle stem cells and improving blood flow to the scalp. Some users report thicker, faster-growing hair. It's sometimes combined with other hair-supporting peptides like GHK-Cu for enhanced effects.
What are the side effects of TB-500?
TB-500 is generally well-tolerated. Possible side effects include temporary lethargy, head rush, and injection site reactions. Some report mild flu-like symptoms initially. Like most healing peptides, there are theoretical concerns about promoting growth in existing tumors, though not demonstrated in research.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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