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PE-22-28

Last reviewed: September 23, 2026 by The Peptide Catalog Team

7-amino-acid spadin fragment blocking the TREK-1 potassium channel — the fast-onset antidepressant research target. Mouse-stage only; no human data.

Overview

Core Benefits

Key Advantages
Lean muscle support
Pairs with training to support strength and muscle preservation.
Body recomposition
Pairs with nutrition to shift fat and lean mass ratios.
Faster recovery
Cuts downtime between sessions and supports joint comfort.
Better sleep depth
Supports deeper sleep cycles and overnight recovery.
Vitality support
Skin, energy, and focus benefits reported in wellness settings.
Stack compatibility
Pairs with ipamorelin to engage complementary GH pathways.

These are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.

PE-22-28 Results Timeline

Progression
1
Week 1–4
Physical Changes
Subtle fat loss, slight muscle fullness
Performance & Recovery
Better sleep, quicker post-workout recovery
Other Benefits
More stable energy, improved mood
2
Month 2–3
Physical Changes
Visible fat reduction (especially belly), increased muscle definition
Performance & Recovery
More workout endurance, less soreness
Other Benefits
Healthier skin tone, sharper focus
3
Month 4–6
Physical Changes
Noticeable lean muscle gain, steady fat loss
Performance & Recovery
Stronger recovery and strength
Other Benefits
Anti-aging effects: better skin elasticity, hair quality, steady energy
4
6+ Months
Physical Changes
Major body recomposition — lower fat % + more muscle
Performance & Recovery
Peak recovery, ability to train harder
Other Benefits
Long-term vitality and youthful look

Timeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.

PE-22-28 Vendors

15% OFF
COA
Limitless Biotech

Limitless Biotech

Score
10/10
Price
$39.09
$45.99
Amount
20mg
Cost/mg
$2.30/mg
Save 15% with code peptideinfo at checkout.
View at Limitless Biotech

Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

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Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

FAQ

How long does reconstituted peptide last?

Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.

Is this peptide legal to purchase?

Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.

New to peptides?

Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

PE-22-28 Research Articles

dosing

PE-22-28 Dosage: 200-400mcg Community Protocol

The intranasal-vs-SubQ split, why community reports cap at 600mcg, and the exact syringe math for 10mg and 20mg vials of this un-trialed TREK-1 peptide.

buying-guide

Where to Buy PE-22-28: 2026 Vendor Status

One tracked source lists PE-22-28 today; most listings are still gray-market. The real availability picture, alerts, and what compares from verified vendors.

reconstitution

PE-22-28 Reconstitution: 10mg Vial to 5mg/mL

The 2mL BAC water standard, intranasal sprayer prep vs injection draws, and why this 7-amino-acid peptide's storage window runs 3-4 weeks.

benefits

PE-22-28: Antidepressant Effects in 4 Days

A 7-amino-acid spadin fragment with 300x the TREK-1 affinity of its parent — and mouse antidepressant markers in 4 days instead of weeks. The evidence.

Disclosure: we may earn affiliate commission from qualifying purchases. Educational information only — not medical advice.