PTD-DBM
A Wnt-activating compound for hair follicle regeneration. PTD-DBM is a cell-penetrating peptide that promotes hair growth by inhibiting CXXC5, a negative regulator of the Wnt/β-catenin signaling pathway. By blocking CXXC5-Dishevelled interaction, it activates Wnt signaling which is essential for hair follicle development and cycling. Research shows it can stimulate new hair growth and increase hair follicle size. Often used topically or via microneedling for androgenetic alopecia and hair thinning.
Compare Prices🧬Key Characteristics
- Type: Cell-penetrating(Topical delivery)
- Target: CXXC5 protein(Wnt pathway inhibitor)
- Effect: Wnt activation(Hair follicle growth)
- Application: Topical/Microneedling(No injection needed)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
PTD-DBM Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Cell-Penetrating Peptide — Wnt/β-Catenin Activator (Hair Growth)Target → Wnt Reactivation → Follicle Growth → Outcomes
CXXC5 (Wnt Pathway Inhibitor) — Blocks the Blocker
PTD-DBM is a cell-penetrating peptide that inhibits CXXC5 — a protein that suppresses the Wnt/β-catenin pathway. By "blocking the blocker," PTD-DBM reactivates Wnt signaling in hair follicles, promoting the anagen (growth) phase.
CXXC5 Inhibition → Wnt/β-Catenin Reactivation
Wnt/β-catenin signaling is essential for hair follicle development and cycling. CXXC5 normally suppresses this pathway as a negative regulator. PTD-DBM disrupts the CXXC5-Dishevelled interaction, allowing Wnt signals to proceed and promote new hair growth and follicle enlargement.
Follicle Reactivation + New Hair Growth
Reactivated Wnt signaling promotes transition of dormant follicles into active growth phase. Research shows increased follicle size and density. Effects are topical/local — this is not a systemic peptide. Often combined with microneedling for enhanced penetration.
New Growth → Thicker Hair (3-6 Months)
Hair growth is slow — expect 3-6 months minimum for visible improvements. New vellus hairs may appear first, gradually thickening. Microneedling sessions (1-2x/week) significantly enhance results. Consistency over months is key.
What Makes This Peptide Different
PTD-DBM is unique in targeting Wnt/β-catenin via CXXC5 inhibition — a fundamentally different mechanism from minoxidil (blood flow), finasteride (DHT blocking), or GHK-Cu (gene expression modulation). The cell-penetrating peptide domain allows it to cross cell membranes topically. Can be combined with other hair-growth treatments for complementary multi-pathway approaches.
Dosing Protocol
Hair Growth / Follicle StimulationEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why topical? PTD-DBM targets scalp follicles locally. Systemic Wnt activation would be undesirable (Wnt signaling is involved in cancer pathways). Topical keeps the effect localized.
Why microneedling? Creates micro-channels that dramatically improve peptide penetration into the dermis where follicle stem cells reside. 1-2x/week is sufficient for enhanced delivery.
Why 3-6 months? Hair growth cycles are slow. Follicle reactivation takes weeks, and visible hair growth takes months. Patience and consistency are essential.
Diagrams
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PTD-DBM Pricing
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Reconstitution calculator
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FAQ
What is PTD-DBM and how does it work?
PTD-DBM is a cell-penetrating peptide that promotes hair growth by activating the Wnt/β-catenin signaling pathway. It works by inhibiting CXXC5, a protein that normally suppresses Wnt signaling. Since Wnt signaling is essential for hair follicle development and cycling, blocking its inhibitor effectively "turns on" hair growth pathways.
What is the Wnt/β-catenin pathway and why is it important for hair?
The Wnt/β-catenin pathway is a critical signaling system that controls hair follicle formation, growth, and cycling. When active, it promotes the anagen (growth) phase of hair. In pattern baldness, this pathway becomes suppressed. PTD-DBM reactivates it by blocking CXXC5, which normally binds to Dishevelled and prevents Wnt signaling.
How is PTD-DBM applied?
PTD-DBM is typically applied topically to the scalp. It can be used daily as a solution or combined with microneedling (1-2x weekly) for enhanced penetration. The "PTD" portion is a cell-penetrating sequence that helps the peptide cross the skin barrier. Evening application is often preferred for overnight absorption.
How long until PTD-DBM shows results?
Hair growth is slow — expect 3-6 months minimum before visible results. Hair follicles need time to transition from dormant to active phases. Early signs may include reduced shedding and finer "vellus" hairs appearing. Full results typically require 6-12 months of consistent use. Patience and consistency are essential.
Can PTD-DBM be combined with other hair treatments?
Yes, PTD-DBM is often combined with other treatments like minoxidil, finasteride, or other peptides (copper peptides, thymulin). Since it works via a different mechanism (Wnt activation), it may be synergistic with treatments targeting other pathways. Microneedling enhances absorption of all topical treatments.
What are the side effects of PTD-DBM?
PTD-DBM is generally well-tolerated topically. Possible side effects include mild scalp irritation, redness (especially with microneedling), and rarely allergic reactions. Since it's applied locally, systemic side effects are unlikely. Long-term safety data is limited as it's primarily a research peptide.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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