VIP
An immune-rebalancing peptide for CIRS, mold illness, and neuroinflammation. VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide with broad immunomodulatory, neuroprotective, and vasodilatory effects. Central to the Shoemaker protocol for CIRS/mold illness treatment. Also researched for pulmonary hypertension, circadian rhythm regulation, and neuroinflammation.
Compare Prices🧬Key Characteristics
- Length: 28 amino acids(Endogenous neuropeptide.)
- Receptors: VPAC1 and VPAC2(G-protein coupled receptors.)
- Administration: Intranasal(Nasal spray for CIRS protocol.)
- Primary Use: CIRS / inflammation(Shoemaker protocol final step.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
VIP Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Neuropeptide — Immunomodulator / VasodilatorReceptor → Immune Rebalancing → Systemic Recovery → Outcomes
VPAC1/VPAC2 Receptors (Immune Cells, Neurons, Vasculature)
VIP (Vasoactive Intestinal Peptide) activates VPAC1 and VPAC2 G-protein coupled receptors distributed widely across immune cells, neurons, pulmonary vasculature, and the GI tract. This broad receptor distribution underlies VIP's diverse effects on immunity, inflammation, and vascular function.
cAMP/PKA → Anti-Inflammatory + Vasodilatory Cascade
VPAC receptor activation increases intracellular cAMP, which shifts immune cells from pro-inflammatory (Th1/Th17) toward regulatory (Treg) phenotypes. In vasculature, cAMP causes smooth muscle relaxation and vasodilation. In neurons, it provides neuroprotective signaling.
Immune Rebalancing + Vasodilation + Neuroprotection
Shifts the immune system from inflammatory to regulatory mode — critical for CIRS (Chronic Inflammatory Response Syndrome) and mold illness. Reduces pulmonary artery pressure. Supports circadian rhythm regulation through SCN (suprachiasmatic nucleus) signaling. Protects neurons from inflammatory damage.
Reduced Inflammation → Breathing Improvement → Energy
In CIRS patients: reduced inflammatory markers (C4a, TGF-β1, MMP-9), improved breathing, and increased energy over weeks to months. Central to the Shoemaker protocol as the final step in CIRS treatment. Also used for pulmonary hypertension and neuroinflammatory conditions.
What Makes This Peptide Different
VIP is uniquely positioned at the intersection of immune, vascular, and neural systems. While Thymosin Alpha-1 enhances adaptive immunity and KPV targets inflammation, VIP rebalances the entire immune response while also addressing vascular and neurological components. The Shoemaker protocol established it as the gold-standard final treatment for CIRS/mold illness.
Dosing Protocol
CIRS Treatment / Immune RegulationEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why nasal spray? VIP nasal spray provides direct access to nasal and pulmonary mucosa — key target tissues in CIRS. Also provides some CNS access for neuroprotective effects.
Why the Shoemaker sequence? VIP is the final step in CIRS treatment because it requires prior steps (binder therapy, MARCoNS treatment) to be completed first. Using VIP before clearing biotoxins can worsen symptoms.
Why 30-day minimum? Immune rebalancing is a gradual process. VIP needs consistent exposure over weeks to shift immune cell phenotypes from inflammatory to regulatory.
VIP Pricing
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5 mg / vial
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorHandling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What is CIRS and how does VIP treat it?
CIRS (Chronic Inflammatory Response Syndrome) is a multi-system illness triggered by biotoxin exposure — most commonly from water-damaged buildings (mold). VIP is the final step in the Shoemaker protocol, used after other inflammatory markers (C4a, TGF-β1, MMP-9, VEGF) have been corrected. It rebalances the immune system from pro-inflammatory (Th1/Th17) to regulatory (Treg) responses.
Why is VIP administered as a nasal spray?
Intranasal delivery targets both the respiratory tract (relevant for CIRS lung inflammation and pulmonary hypertension) and the CNS via the olfactory pathway. It avoids first-pass liver metabolism and provides rapid local effects. The standard formulation is 50 mcg per spray, typically dosed 4 times daily.
What lab markers should be monitored during VIP therapy?
Key markers include: C4a (complement activation), TGF-β1 (fibrosis/immune dysregulation), MMP-9 (tissue remodeling), VEGF (vascular growth), MSH (melanocyte-stimulating hormone), and VIP levels themselves. Pulmonary artery pressure should also be monitored via echocardiogram. VIP should only be started after these markers are trending toward normal from earlier protocol steps.
Can VIP be used for conditions other than CIRS?
Research has explored VIP for pulmonary arterial hypertension, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative conditions. Its role as a neuropeptide means it also regulates circadian rhythms (via the suprachiasmatic nucleus) and protects neurons from inflammatory damage. However, CIRS treatment remains its most established clinical application.
What are the side effects of VIP?
VIP is generally well-tolerated at therapeutic doses. Some patients report mild nasal irritation, transient flushing, or loose stools (VIP stimulates intestinal secretion — it's called "vasoactive intestinal peptide" for a reason). Rarely, excessive doses can cause hypotension due to vasodilation. Monitoring by a CIRS-literate physician is recommended.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
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