Thymosin Alpha-1
An immune-boosting peptide used in 30+ countries for viral defense. Thymosin Alpha-1 (Tα1) is a 28-amino acid immunomodulatory peptide naturally produced by the thymus gland. It enhances T-cell function, dendritic cell maturation, and cytokine balance. Approved in over 35 countries as Zadaxin for hepatitis B/C and as an immune adjuvant. Research explores applications in chronic infections, cancer immunotherapy, immune deficiency, and vaccine enhancement.
Compare Prices🧬Key Characteristics
- Type: Thymic Peptide(28 amino acids)
- Brand Name: Zadaxin(Approved 35+ countries)
- Target: T-cells / DCs(Immune modulation)
- Half-Life: ~2 hours(2x weekly dosing)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
Thymosin Alpha-1 Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Immune Peptide — T-Cell ModulatorTarget → Immune Activation → T-Cell Response → Outcomes
TLR2/TLR9 + Dendritic Cells + T-Cell Precursors
Thymosin Alpha-1 activates toll-like receptors (TLR2, TLR9) on dendritic cells and promotes T-cell maturation from precursors. It's a thymic peptide — naturally produced by the thymus gland, which shrinks with age, contributing to immune decline.
TLR Activation → Dendritic Cell Maturation → T-Cell Response
TLR2/TLR9 stimulation on dendritic cells enhances antigen presentation — improving the immune system's ability to identify threats. Simultaneously promotes T-cell differentiation and balances Th1/Th2 immune responses.
Enhanced Adaptive Immunity + Immune Balance
Improved T-cell function and numbers. Better immune surveillance. Balanced inflammatory responses (doesn't just boost — it modulates). Approved in 35+ countries as Zadaxin for hepatitis B/C and as a cancer immunotherapy adjuvant.
Fewer Infections → Better Recovery → Immune Resilience
Reduced frequency and severity of infections over weeks to months. Better recovery from illness. Improved response to vaccines. Effects are measured by immune markers (T-cell counts, function) rather than felt as acute changes.
What Makes This Peptide Different
Thymosin Alpha-1 is approved in 35+ countries — one of the most clinically validated immune peptides. Unlike broad immune stimulants, it specifically enhances adaptive immunity (T-cells, dendritic cells) while maintaining immune balance. Particularly relevant for age-related immune decline (immunosenescence), chronic infections, and as a vaccine adjuvant.
Dosing Protocol
ImmunityEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why 5 days on, 2 days off? This schedule (1.5 mg daily) maintains consistent immune modulation while giving the body periodic recovery days. The clinical Zadaxin protocol uses 1.6 mg twice weekly — both approaches achieve sustained T-cell support.
Why 8-week cycles? Immune modulation requires sustained treatment to see measurable T-cell changes (8 weeks on, 8 weeks off). Short courses don't allow enough time for immune system adaptation.
Diagrams
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Thymosin Alpha-1 Pricing
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5 mg / vial
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What is Thymosin Alpha-1?
Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide naturally produced by the thymus gland. It plays a crucial role in immune system regulation, particularly T-cell maturation and function. It's approved in over 35 countries as Zadaxin for treating hepatitis B, hepatitis C, and as an immune adjuvant for vaccines and cancer therapy.
How does Thymosin Alpha-1 work?
Tα1 modulates the immune system through multiple mechanisms: enhancing T-cell differentiation and function, promoting dendritic cell maturation, balancing Th1/Th2 cytokine responses, and increasing natural killer cell activity. It helps restore immune function in immunocompromised individuals without causing dangerous overstimulation.
What is Thymosin Alpha-1 used for?
Clinically, Tα1 is used for chronic hepatitis B/C, as an immune adjuvant in cancer therapy, for vaccine enhancement in immunocompromised patients, and for chronic infections. Research explores applications in sepsis, immunodeficiency, and as supportive therapy for various conditions requiring immune support.
What is the difference between Thymosin Alpha-1 and Thymosin Beta-4?
Despite similar names, these are different peptides with different functions. Thymosin Alpha-1 is an immunomodulator that enhances T-cell function. Thymosin Beta-4 (TB-4/TB-500) is involved in tissue repair, cell migration, and wound healing. They come from different parts of the thymus and have distinct mechanisms of action.
What are the side effects of Thymosin Alpha-1?
Tα1 is generally very well-tolerated with an excellent safety profile established over decades of clinical use. Minor side effects may include injection site reactions (redness, mild pain) and rarely mild flu-like symptoms. It does not cause the dangerous immune overstimulation seen with some other immunomodulators.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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