Thymalin dosing in the published Russian clinical literature centers on 5-10 mg intramuscular once daily, given as a short course of 5-10 consecutive days and repeated after roughly six months. Community and research-chemical sources instead describe subcutaneous use at loosely similar per-course amounts, but that route has no controlled-trial basis. This guide separates the two so it is clear which figures came from human studies and which did not.
Thymalin is a polypeptide fraction extracted from thymus tissue — a mixture of low-molecular-weight peptides, not a single defined molecule. That matters for dosing: because it is an extract rather than a synthetic sequence, batch composition is not standardized the way a defined peptide would be, and the dose figures below describe historical clinical practice, not a validated modern protocol.
Research-context information only. Thymalin is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.
Thymalin is a Soviet-era thymic peptide bioregulator developed in the 1970s-80s and used clinically in Russia as an immunocorrector. The sections below cover the documented course protocol, routes, reconstitution math, and the honest provenance of these numbers.
Thymalin Dosing Table
Match your vial size below — reconstitution and dose math update automatically.
Doses are from the Russian IM clinical literature, which dissolved the powder in saline or procaine. The unit math uses the community 2 mL bacteriostatic-water reconstitution; community SubQ use has no controlled-trial basis.
| Dose | Syringe units | mL volume | Schedule |
|---|---|---|---|
| 5 mg | 100 units | 1 mL | Daily IM, 5-10 day courseClinical-literature (Russian) |
| 10 mg | 200 units | 2 mL | Daily IM, 5-10 day courseClinical-literature (Russian); over 1 mL, two draws or a larger syringe |
Math assumes U-100 insulin syringes (1 mL = 100 units). Verify your syringe matches before injecting. Round half-units to the nearest visible mark.
Quick Reference: Protocol
The table below reflects what the Russian clinical literature documented — not a recommended schedule. There is no Jay Campbell/Hunter Williams cheat-sheet entry for Thymalin, so no "standard protocol" figure exists in that source.
| Parameter | Clinical-literature figure (Russian sources) |
|---|---|
| Dose | 5-10 mg (some reports 1-10 mg) |
| Route | Intramuscular injection |
| Frequency | Once daily |
| Course length | 5-10 consecutive days (cited 3-10 days) |
| Repeat interval | Course repeated after ~6 months; strongest signal from annually repeated courses |
| Diluent | Sterile saline or procaine |
| Supplied as | Lyophilized powder for injection |
| Storage | Refrigerate at 2-8C, use reconstituted vial within 28 days |
Community-reported variation (label: community/anecdotal — not from controlled trials): research-chemical and community protocols commonly describe subcutaneous administration at roughly 5-20 mg per course spread over several days, repeated 1-2 times per year. No controlled-trial basis supports the subcutaneous route or these amounts — the published human data is intramuscular. These figures are reported here as community signal, not as validated dosing.
Routes of Administration
- Intramuscular (IM) — the route used in the published human studies. Original protocols dissolved the powder in sterile saline or procaine and injected once daily across the course.
- Subcutaneous (SC) — described in community and vendor sources, not in the controlled literature. Community reports frame SC as the convenient at-home route; it carries no trial support for Thymalin specifically.
The disambiguation matters when comparing route notes across sources: Thymalin is a thymus extract fraction, distinct from thymulin (a single zinc-dependent nonapeptide) and thymosin alpha-1 (a defined 28-amino-acid peptide). Dosing figures for those two compounds do not transfer to Thymalin, and vice versa.
Reconstitution Quick Reference
The original clinical protocols dissolved Thymalin in sterile saline or procaine for intramuscular injection. Community reconstitution guides instead describe bacteriostatic water, as with other research peptides.
| Vial Size | BAC Water | Concentration | 5 mg dose | 10 mg dose |
|---|---|---|---|---|
| 10 mg | 2 mL | 5 mg/mL | 1.0 mL (100 units) | 2.0 mL (200 units — two draws or a larger syringe) |
At 5 mg/mL, a 5 mg dose is 1.0 mL — a large draw relative to most peptides because these are milligram-scale, not microgram-scale, doses. Community protocols describe swirling gently (not shaking), refrigerating at 2-8C, and using the reconstituted vial within 28 days.
For the full step-by-step mixing walkthrough, see our Reconstitution Guide.
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