Epitalon
A telomere-targeting peptide for longevity and cellular rejuvenation. Epitalon (Epithalon) is a synthetic tetrapeptide studied for its effects on telomerase activation and potential anti-aging properties. Based on the pineal gland peptide Epithalamin. Researched for longevity, sleep regulation, and cellular health.
Compare Prices🧬Key Characteristics
- Length: 4 amino acids(Tetrapeptide structure.)
- Origin: Pineal gland(Synthetic version of Epithalamin.)
- Target: Telomerase(May activate telomerase enzyme.)
- Primary Use: Longevity research(Anti-aging, telomere support.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
Epitalon Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Longevity Peptide — Telomerase ActivatorTarget → Telomerase Activation → Cellular Renewal → Outcomes
Telomerase (hTERT) + Pineal Gland
Epitalon activates telomerase, the enzyme that maintains telomere length at chromosome ends. It also stimulates the pineal gland to normalize melatonin production, which declines with age. These two targets address both cellular aging and circadian rhythm disruption.
Telomerase Activation → Telomere Maintenance
By activating telomerase, Epitalon helps maintain telomere length — the protective caps on chromosomes that shorten with each cell division. Shortened telomeres are associated with cellular senescence and aging. Pineal gland stimulation restores youthful melatonin patterns.
Cellular Protection + Circadian Normalization
Telomere maintenance supports cellular longevity across multiple tissue types. Normalized melatonin production improves sleep architecture, antioxidant defense, and immune function. The combination targets two fundamental mechanisms of aging.
Better Sleep → Skin Quality → Vitality
Improved sleep depth and quality (often the first effect, weeks 1-2). Gradual improvements in skin elasticity, hair quality, and overall vitality over months. Benefits are subtle and cumulative — Epitalon works at a fundamental cellular level rather than producing dramatic acute effects.
What Makes This Peptide Different
Epitalon is unique in targeting telomere maintenance — a fundamental mechanism of cellular aging. Unlike GH peptides (hormonal), healing peptides (tissue repair), or metabolic peptides (energy), Epitalon addresses aging at the chromosomal level. The short, intensive dosing protocol (20 consecutive days, 2-3 cycles per year) reflects its mechanism — telomerase activation doesn't require continuous stimulation.
Dosing Protocol
Longevity / TelomeresEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why 20 consecutive days? Research protocols use short intensive courses to activate telomerase, followed by extended breaks. Continuous daily use is not necessary — telomerase activation has a lasting effect once initiated.
Why 2-3 cycles per year? Spacing cycles 4-6 months apart allows time for the telomere-protective effects to manifest. This is a maintenance approach, not a continuous treatment.
Why evening? Epitalon's pineal gland stimulation aligns with evening/nighttime melatonin production cycles.
Diagrams
Hover for preview • Click to open full size
Epitalon Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
10 mg / vial
In-stock offersBuy more, save more
Looking for medical guidance?
Join the waitlist for doctor-guided peptide plans. We'll notify you when telehealth consultations are available in your state.
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What is Epitalon studied for?
Epitalon is studied for its effects on telomerase activation and potential anti-aging properties. It's a synthetic version of Epithalamin, a peptide produced by the pineal gland. Research focuses on longevity, sleep regulation, and cellular health.
How does Epitalon work?
Epitalon activates telomerase, the enzyme that lengthens telomeres — the protective caps on chromosomes that shorten with age. Shortened telomeres are associated with cellular aging and death. By activating telomerase, Epitalon may help maintain telomere length and extend cellular lifespan.
What are telomeres and why do they matter?
Telomeres are protective DNA sequences at the ends of chromosomes, like the plastic tips on shoelaces. Each time a cell divides, telomeres shorten. When they become too short, cells enter senescence or die. Telomere length is considered a biomarker of biological age — longer telomeres correlate with longevity.
What is Epithalamin and how does it relate to Epitalon?
Epithalamin is a natural peptide extract from the pineal gland, discovered by Russian scientist Vladimir Khavinson. Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) designed to mimic Epithalamin's active component. The synthetic version provides consistent dosing and avoids animal-derived material.
Does Epitalon affect sleep and melatonin?
Yes, Epitalon influences the pineal gland and may help regulate melatonin production. Users often report improved sleep quality and normalized circadian rhythms. This is especially relevant for older individuals whose pineal function and melatonin production have declined with age.
What is the typical Epitalon protocol?
A common research dosage is 2 mg per day (20 units on 1ml syringe), administered via subcutaneous injection in the PM. Protocol: 20 days in a row, repeated 3 times per year. The cyclic approach mimics how the original Epithalamin research was conducted.
What were the results of Epitalon research?
Russian studies by Dr. Khavinson showed Epithalamin/Epitalon increased lifespan in animals and improved various biomarkers in elderly humans. One study of 266 elderly patients over 6 years showed reduced mortality in the treatment group. However, these studies have limited replication in Western research and more studies are needed.
What are the side effects of Epitalon?
Epitalon is generally well-tolerated with minimal reported side effects. Some users report mild injection site reactions or temporary headache. The main theoretical concern is that telomerase activation could potentially promote cancer cell growth, though no evidence of this has been observed in studies. Long-term safety data is limited.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.
Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
Disclosure: we may earn affiliate commission from qualifying purchases. Educational information only — not medical advice.