Disclosure: We earn a commission from vendors on this page. Rankings are based on price, COA availability, and reputation.
Best Metabolic Peptides (2026)
Metabolic peptides target fat loss through different mechanisms — from GLP-1 appetite suppression to direct fat cell reprogramming. Here are the best vendors for each.
At a Glance
1Retatrutide3 vendorsMost potent weight loss peptide available. Triple receptor action drives unmatched fat loss with manageable GI side effects.
Most potent weight loss peptide available. Triple receptor action drives unmatched fat loss with manageable GI side effects.
Most potent weight loss peptide available. Triple receptor action drives unmatched fat loss with manageable GI side effects.
| Vendor | Price | Amount | $/mg | COA | |
|---|---|---|---|---|---|
| EZ Peptides | $44.00 | 6mg | $7.33/mg | Yes | Buy → |
| Ascension Peptides | $100.00 | 10mg | $10.00/mg | Yes | Buy → |
| Royal Peptides | $55.00 | 10mg | $5.50/mg | Yes | Buy → |
2Tirzepatide3 vendorsFDA-approved dual agonist with excellent fat loss and metabolic improvements. Well-tolerated long term.
FDA-approved dual agonist with excellent fat loss and metabolic improvements. Well-tolerated long term.
FDA-approved dual agonist with excellent fat loss and metabolic improvements. Well-tolerated long term.
| Vendor | Price | Amount | $/mg | COA | |
|---|---|---|---|---|---|
| EZ Peptides | $44.00 | 10mg | $4.40/mg | Yes | Buy → |
| Ascension Peptides | $75.00 | 10mg | $7.50/mg | Yes | Buy → |
| Royal Peptides | $50.00 | 5mg | $10.00/mg | Yes | Buy → |
3Tesofensine2 vendorsOral dopamine/norepinephrine/serotonin reuptake inhibitor. Strong fat loss in trials (~12.8% at 1mg) but watch for elevated heart rate.
Oral dopamine/norepinephrine/serotonin reuptake inhibitor. Strong fat loss in trials (~12.8% at 1mg) but watch for elevated heart rate.
4Semaglutide3 vendorsProven single GLP-1 agonist. Reliable ~15% weight loss. Most safety data available.
Proven single GLP-1 agonist. Reliable ~15% weight loss. Most safety data available.
Proven single GLP-1 agonist. Reliable ~15% weight loss. Most safety data available.
| Vendor | Price | Amount | $/mg | COA | |
|---|---|---|---|---|---|
| EZ Peptides | $35.00 | 5mg | $7.00/mg | Yes | Buy → |
| Ion Peptide | $39.00 | 10mg | $3.90/mg | Yes | Buy → |
| Royal Peptides | $45.00 | 5mg | $9.00/mg | Yes | Buy → |
55-Amino-1MQ3 vendorsNNMT inhibitor — novel mechanism targeting fat cell metabolism directly. Early research promising but limited human data.
NNMT inhibitor — novel mechanism targeting fat cell metabolism directly. Early research promising but limited human data.
NNMT inhibitor — novel mechanism targeting fat cell metabolism directly. Early research promising but limited human data.
| Vendor | Price | Amount | $/mg | COA | |
|---|---|---|---|---|---|
| EZ Peptides | $68.00 | 50mg | $1.36/mg | Yes | Buy → |
| Ascension Peptides | $75.00 | 10mg | $7.50/mg | Yes | Buy → |
| Ion Peptide | $35.00 | 50mg | $0.70/mg | Yes | Buy → |
6AOD-96042 vendorsGH fragment targeting fat. Mild and well-tolerated but modest results compared to GLP-1 class.
GH fragment targeting fat. Mild and well-tolerated but modest results compared to GLP-1 class.
How We Rank Vendors
Every vendor is scored on three factors: price per mg (40%), third-party COA testing (30%), and community reputation (30%). Scores floor at 8.0 — if a vendor is on our site, they are worth buying from.
Normalized to $/mg for fair comparison across vial sizes.
Third-party lab results confirming purity and identity.
Community feedback, shipping reliability, and track record.