Gonadorelin

GnRHLyophilized powder

Gonadorelin is synthetic gonadotropin-releasing hormone (GnRH), a 10-amino-acid peptide that signals the pituitary gland to release LH and FSH. Prescription gonadorelin products have been FDA-approved for diagnostic and fertility uses; the research-grade vials listed here are a different, unapproved product. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$11.23/mg · In stock

Price

$22.46

List

$24.95

Buy 2 mg at Swiss Chems

Price shown uses code THEPEPTIDECATALOG at Swiss Chems's checkout (10% off list).

Sold by Swiss Chems. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

GonadorelinSwiss Chems

Research use only

Certificate of AnalysisCertificates from Swiss ChemsView

Listed on our gonadorelin vendor comparison, ordered by our vendor rankings
Lyophilized powder · laboratory research use only

Research-context information only. Gonadorelin is the active ingredient in FDA-approved products for evaluating hypothalamic-pituitary-gonadal function and inducing ovulation in hypothalamic amenorrhea; research-peptide and compounded forms are not FDA-approved and are sold for research purposes only. Protocols, doses, and reactions reported below come from clinical trials and community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

Gonadorelin Vial Sizes & Prices

Gonadorelin vial sizes, prices and lots at Swiss Chems
Size	List	With our code	Per mg	Availability
2 mg	$24.95	$22.46	$11.23	In stock

Prices checked today, 5:05 AM CT on Swiss Chems's site, with code THEPEPTIDECATALOG applied. The lot certificate is on Swiss Chems's product page. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Test results

Gonadorelin Certificate of Analysis

Swiss Chems publishes certificates on its own site. Match the lot number on the vial to its certificate.

View the Gonadorelin certificate on Swiss Chems's product page.

How to check one: how to verify a peptide COA.

Gonadorelin Dosing in Clinical Research

HPG-Axis Support (Research / No Validated Community Dose)

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size

2 mg

Reconstitution

2 ml BAC water (1,000 mcg/ml)

Dose

100 mcg (10 units on 1ml syringe) — community convention, not a trial dose

Timing

Consistent time of day

Frequency

Community use is commonly 2x per week

Duration

Ongoing in community protocols; no validated course length

Protocol Notes

Synthetic GnRH (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) acting on pituitary GnRH receptors to release LH and FSH. The response is delivery-pattern dependent: pulsatile administration every 60-120 minutes stimulates LH/FSH, while continuous exposure downregulates the receptor and suppresses them — the same mechanism behind GnRH-agonist chemical castration. Terminal half-life is roughly 10-40 minutes. Clinical efficacy evidence comes from pump-delivered pulsatile GnRH in congenital hypogonadotropic hypogonadism; that data does not transfer to the twice-weekly subcutaneous schedule common in community use. Unlike HCG, which acts directly on testicular Leydig cells, gonadorelin acts one step higher, at the pituitary.

Why This Dosing Protocol

Why the pattern matters more than the number. Because the GnRH receptor downregulates under continuous exposure, the delivery schedule — not the milligram amount — determines whether LH and FSH go up or down. The clinical protocols that established efficacy used an infusion pump delivering physiologic pulses every 60-120 minutes.

Why community dosing is a convention, not evidence. Community protocols use microgram-scale subcutaneous injections, commonly around 100 mcg a couple of times per week. That schedule does not reproduce the pulsatile pump pattern the trial data comes from, and no controlled study has evaluated it. Treat the numbers as reported practice, not a validated dose.

Full Dosing Guide Reconstitution Calculator Cycle Cost Calculator

How Gonadorelin Works

Synthetic GnRH Decapeptide — Pituitary Gonadotropin Secretagogue

Receptor → GnRH Cascade → Hormone Production → Outcomes

Target

GnRH Receptor (GnRHR) on Pituitary Gonadotrophs

Gonadorelin is synthetic gonadotropin-releasing hormone — the decapeptide pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂, identical to the hypothalamic hormone. It binds the GnRH receptor (GnRHR), a Gq/11-coupled GPCR expressed on gonadotroph cells of the anterior pituitary. That places it one step above HCG in the reproductive cascade: HCG acts directly on testicular Leydig cells, while gonadorelin signals the pituitary and lets the pituitary do the work.

Cellular Signal

Gq/11 → Phospholipase C → LH and FSH Release

Receptor binding activates Gq/11 and the phospholipase C pathway inside the gonadotroph, which drives release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The signal is short-lived by design: gonadorelin has a distribution half-life of roughly 2-10 minutes and a terminal half-life of about 10-40 minutes.

Systemic Effect

Delivery Pattern Decides Stimulation vs Suppression

This is the central point of the compound. Pulsatile exposure — the physiologic pattern, roughly every 60-120 minutes — stimulates LH and FSH release. Continuous exposure does the opposite: the GnRH receptor downregulates and LH/FSH are suppressed. That suppression is not a side effect but the deliberate mechanism behind GnRH-agonist chemical castration. The same molecule produces opposite outcomes depending on how it is delivered.

What You Notice

Bloodwork, Not Sensation

Any effect is read on gonadotropin and downstream sex-hormone labs rather than felt directly. Published efficacy data comes from pump-delivered pulsatile GnRH in congenital hypogonadotropic hypogonadism, not from the twice-weekly subcutaneous schedule common in community use — so that data should not be read as predicting what a community protocol does.

What Makes This Peptide Different

Gonadorelin is synthetic GnRH itself, not an analog — which makes it the most upstream compound in this category. Where HCG substitutes for LH at the gonad and kisspeptin acts above the hypothalamus to trigger endogenous GnRH release, gonadorelin acts at the pituitary in between. Its defining and most misunderstood property is that the direction of its effect is set by dosing pattern, not dose size: pulsatile stimulates, continuous suppresses.

Technical specifications

Gonadorelin chemical & analytical data

Also known as: GnRH
Receptor targets: GnRH receptor (GnRHR) — pituitary gonadotrophs
Backbone length: 10 amino acids
Modifications: N-terminal pyroglutamate (pGlu); C-terminal glycinamide (amidation); Sequence identical to native GnRH
Half-life (clinical PK): ~2–10 min distribution, ~10–40 min terminal
Form: Lyophilized (freeze-dried) powder in a sealed vial
Presentation: 2 mg
Regulatory status: Active ingredient in FDA-approved prescription products; research-grade vials are not FDA-approved.

Gonadorelin Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

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Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer

1+ year at -20°C

Reconstituted: Fridge

4 weeks max at 2-8°C

View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)

Freezer (-20°C): 1+ year
Refrigerator (2-8°C): 1-3 months
Room temperature: 2-3 weeks (emergency only)

Reconstituted storage (fragile)

MUST refrigerate at 2-8°C
4-week maximum shelf life
NEVER freeze after reconstitution
Use bacteriostatic water for multi-dose

8 answers

Gonadorelin FAQ: Buying, COA, Storage & Research

What is gonadorelin?

Gonadorelin is synthetic gonadotropin-releasing hormone (GnRH) — a decapeptide with the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂, identical to the hormone the hypothalamus releases. It binds the GnRH receptor on gonadotroph cells in the anterior pituitary and triggers release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is very short-acting, with a distribution half-life of roughly 2-10 minutes and a terminal half-life of about 10-40 minutes.

Why does the dosing pattern change what gonadorelin does?

Because the GnRH receptor responds to rhythm, not just exposure. Pulsatile delivery — the physiologic pattern, roughly every 60-120 minutes — stimulates LH and FSH release. Continuous exposure downregulates the receptor and suppresses LH and FSH instead. That suppression is the documented mechanism behind GnRH-agonist chemical castration. The same molecule can drive the axis in either direction depending on how it is delivered, which is the single most important thing to understand about it.

How is gonadorelin different from HCG?

They act at different levels of the same cascade. HCG mimics LH and acts directly on the LH receptor of testicular Leydig cells, bypassing the pituitary entirely. Gonadorelin acts one step higher — it signals the pituitary to release its own LH and FSH. That difference means gonadorelin depends on a functioning pituitary and on an appropriate delivery pattern, while HCG does not.

What does the clinical evidence actually cover?

The efficacy evidence for GnRH comes from pump-delivered pulsatile administration in congenital hypogonadotropic hypogonadism, where an infusion pump reproduces physiologic pulses every 60-120 minutes. That is a different intervention from the twice-weekly subcutaneous injections common in community use, and the pump data should not be read as supporting that schedule. No controlled trial has evaluated the community protocol.

Is there an established community dose?

No validated one. Community protocols reference microgram-scale subcutaneous doses, commonly around 100 mcg a couple of times per week. Those figures are reported convention rather than trial-derived numbers. Because dosing is microgram-scale, a single 2 mg vial covers a large number of doses. Gonadorelin sold by research-peptide vendors is not FDA-approved and is labeled for research purposes only; this page reports what published research and community sources document, not medical advice.

How long does reconstituted peptide last?

Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.

Is this peptide legal to purchase?

Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.

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Gonadorelin Research Articles

dosing

Gonadorelin Dosing: 100mcg SubQ vs 10mcg/90min

Pulsatile delivery raises LH and FSH; continuous delivery suppresses them. Covers 10mcg/90min pump trials, community 100mcg subQ figures, and unit math.

comparison

Gonadorelin vs HCG: One Clear Winner on TRT

Gonadorelin acts on the pituitary, HCG on the testes directly. That one step down the axis decides which reliably holds testicular function.

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