DSIP

delta sleep-inducing peptideLyophilized powder

DSIP (delta sleep-inducing peptide) is a 9-amino-acid neuropeptide first isolated in the 1970s and studied for its links to slow-wave sleep and stress-hormone regulation. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$4.62/mg · lot DSP-062026-1 · 99.85% · In stock

Price

$23.10

List

$33.00

Buy 5 mg at Nura Peptide

Price shown uses code thepeptidecatalog at Nura Peptide's checkout (30% off list).

Sold by Nura Peptide as DSIP 5mg. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

DSIP research vial sold by Nura Peptide as DSIP 5mg
Third-party tested≥99.85% reported purityResearch use only
Certificate of AnalysisLot DSP-062026-1 · 99.85%View
  • Certificate of Analysis published for every lot (Freedom Diagnostics Testing)
  • Current lots report 99.85% purity or higher
  • Ships from a U.S. fulfillment center, per Nura Peptide
  • Lyophilized powder · laboratory research use only
Research-context information only. DSIP is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

DSIP Vial Sizes, Prices & Lots

DSIP vial sizes, prices and lots at Nura Peptide
SizeListWith our codePer mgAvailabilityLot · purity
5 mg$33.00$23.10$4.62In stockDSP-062026-1 · 99.85%

Prices checked today, 6:20 AM CT on Nura Peptide's site, with code thepeptidecatalog applied. Lot data from Nura Peptide's COA page, checked today, 8:03 PM CT. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Verified test results

DSIP Certificate of Analysis

Nura Peptide publishes a third-party certificate for each lot of DSIP 5mg. The figures below are copied from Nura Peptide's current-lot listings, checked today, 8:03 PM CT (refreshed hourly; hidden if older than 24 hours). Match the lot number on the vial to its certificate.

All lots on record: Nura Peptide COA library. How to check one: how to verify a peptide COA.

DSIP Dosing in Clinical Research

Sleep Quality / Stress Relief

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
5 mg
Reconstitution
2 ml BAC water
Dose
250 mcg (10 units on 1ml syringe)
Timing
1-3 hours before bed
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Protocol Notes
Delta sleep-inducing peptide — promotes slow-wave (delta) sleep without sedation or morning grogginess. No tolerance or dependence reported. Effects often noticeable from first dose.

Why This Dosing Protocol

Why before bed (30-60 min)? DSIP promotes natural sleep onset. Timing it before the desired sleep window allows the peptide to enhance the natural transition into slow-wave sleep.

Why cycling? While no tolerance has been demonstrated, cycling (2-4 weeks on, 1-2 weeks off) is a conservative approach that maintains efficacy and allows assessment of baseline sleep quality improvements.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator

How DSIP Works

Neuropeptide — Delta Sleep Inducer

Target → Neuromodulation → Sleep Enhancement → Outcomes

1
Target

Multiple CNS Targets (GABAergic, Serotonergic, Opioid Systems)

DSIP (Delta Sleep-Inducing Peptide) is a 9-amino-acid neuropeptide that modulates multiple neurotransmitter systems simultaneously. It enhances GABAergic signaling, modulates serotonin pathways, and interacts with the opioid system — all converging on sleep promotion and stress reduction.

2
Cellular Signal

Multi-System Neuromodulation → Sleep Architecture Enhancement

DSIP promotes slow-wave (delta) sleep by modulating the balance between excitatory and inhibitory neurotransmission. It reduces cortisol and ACTH (stress hormones) while enhancing serotonin-mediated sleep induction. Unlike benzodiazepines, it works with natural sleep architecture rather than overriding it.

3
Systemic Effect

Improved Sleep Quality + Stress Hormone Regulation

Enhanced sleep efficiency (more time asleep vs. in bed), reduced sleep latency (faster to fall asleep), and increased slow-wave sleep duration. Simultaneously normalizes stress hormone profiles — reduced cortisol and improved HPA axis regulation. Also studied for pain modulation effects.

4
What You Notice

Faster Sleep Onset → Deeper Sleep → Refreshed Mornings

Faster time to fall asleep (often noticeable first night). Deeper, more restorative sleep quality. Feeling more refreshed upon waking. Reduced stress and improved stress resilience during the day. Effects build over multi-day protocols. No hangover or grogginess — unlike pharmaceutical sleep aids.

What Makes This Peptide Different

DSIP is unique in enhancing natural sleep architecture rather than sedating. While Selank reduces anxiety (which can help sleep indirectly), DSIP directly promotes delta wave sleep patterns. Its dual sleep + stress-protective profile makes it particularly useful for stress-related insomnia. No dependence or tolerance has been reported in research.

DSIP Clinical Evidence

Two parallel grades per outcome — clinical RCT depth and real-world community adoption. See the Research Overview below for citations and detail.

OutcomeClinical EvidenceCommunity Evidence
Sleep induction in chronic insomniaWeakPreliminary
Phase-shifted insomnia / circadianWeakPreliminary
Modern sleep clinical usePreliminaryPreliminary

DSIP Research Overview

Outcome-by-outcome look at what the evidence actually supports for DSIP, including human vs. animal study counts and our editorial take on each.

Sleep induction in chronic insomnia

Clinical:WeakCommunity:Preliminary

Schneider-Helmert and colleagues published a series of small clinical reports in the 1980s using synthetic DSIP IV in chronic insomniacs, with reports of longer sleep duration, fewer interruptions, and slightly more REM sleep. The literature is small (N typically < 30 per study), the molecule is not approved as a sleep agent anywhere, and modern trials with proper polysomnography control have not been replicated.

3 human studies · 8 animal studies

Key findings & citations
  • Schneider-Helmert 1981: longer sleep duration and quality with synthetic DSIP IV in chronic insomniacs.
  • 1987 case: delayed sleep phase advanced by 5 hours with DSIP, withdrawing benzodiazepine.
  • All published trials are small, dated (1980s), and lack modern polysomnography rigor.
  • Not approved as a sleep agent in any major market.

Our take

Old literature, small trials, never approved. Modern sleep medicine has moved on; community use is largely nostalgic.

What DSIP doesn't do

Claims that current evidence does not support. Worth knowing before you set expectations.

Technical specifications

DSIP chemical & analytical data

Also known as
delta sleep-inducing peptide
Sold by Nura Peptide as
DSIP 5mg
Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
5 mg
Purity on current lots (COA)
99.85%
Testing laboratory
Freedom Diagnostics Testing
Regulatory status
Research peptide; research-grade vials are not FDA-approved.

DSIP Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

8 answers

DSIP FAQ: Buying, COA, Storage & Research

How does DSIP improve sleep without causing sedation?
DSIP modulates multiple neuromodulatory systems — including GABAergic, opioidergic, and glutamatergic pathways — to enhance the body's natural sleep architecture rather than override it. Unlike benzodiazepines or Z-drugs that force sedation, DSIP promotes slow-wave (delta) sleep while allowing normal sleep cycling. This means no grogginess, no cognitive impairment, and natural waking.
Can DSIP cause tolerance or dependence?
No tolerance or dependence has been documented in clinical literature. In fact, DSIP has been studied as a potential treatment for opiate and alcohol withdrawal — the opposite of a dependence-forming drug. Most protocols still recommend cycling (2-4 weeks on, 2 weeks off) as a precaution.
What is the best dose and timing for DSIP?
Community protocols typically use 100–300 mcg subcutaneously, administered 30–60 minutes before bed. Most users start at 100 mcg and increase based on response. Some clinical studies used morning IV infusions and still saw delayed sleep benefits, but evening subcutaneous dosing is the standard research approach.
What other benefits does DSIP have beyond sleep?
Research suggests DSIP has stress-protective properties — it reduces cortisol and ACTH levels, improving HPA axis function. It also shows analgesic (pain-reducing) activity through opioid system interactions, antioxidant effects, and potential benefits for substance withdrawal. Some studies found it normalizes blood pressure and improves heart rate variability.
Can DSIP be stacked with other sleep peptides?
Common stacks include DSIP with Selank (for anxiolytic support if stress contributes to insomnia), Epitalon (for melatonin regulation and telomere benefits), or low-dose Ipamorelin (for synergistic GH release during deep sleep). Each peptide should be injected at a separate site. Avoid combining with pharmaceutical sedatives.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

DSIP Research Articles

guides

DSIP Dosage Chart: 250mcg Before Bed Protocol

Most miss the 5-on/2-off cycling that prevents tolerance. Covers 250mcg timing, reconstitution, and Selank/Epitalon stacking.

guides

Buy DSIP: Compare 5 Vendors, From $24.95

Compare 5 DSIP vendors side by side: from $24.95 a vial, best value $5.80/mg. Codes save up to 50%. Vial sizes, COA status, real cost per week.

results

DSIP Results: Week-by-Week Timeline

Sleep changes start within 1-3 nights — but DSIP's deeper effects take weeks. Full timeline from first dose through a complete cycle.

benefits

DSIP Benefits: 97% Withdrawal Recovery Rate

DSIP does more than induce sleep — its strongest data is in withdrawal management. 5 research-backed effects with clinical citations.

Compare DSIP Vendors Before You Buy

Disclosure: we may earn affiliate commission from qualifying purchases. Educational information only — not medical advice.