Research-context information only. Tesofensine is an investigational drug not approved by the FDA. Protocols, doses, and reactions reported below come from published clinical trials and self-reported community sources. Possession or use of investigational drugs outside an authorized clinical trial may be illegal in your jurisdiction. Consult a licensed physician for personal medical decisions.
The buying problem is that tesofensine is a small molecule (not peptide), shipped almost exclusively in capsules, with limited vendor selection compared to high-volume research peptides.
This guide covers documented per-mg pricing, COA verification, format selection, and red flags. For dosing context, see the tesofensine dosing guide.
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How to Verify Tesofensine Quality
What a COA Should Include
Identity Confirmation
Mass spec confirming 327.27 Da (free base) or labeled salt form mass
NMR or LC-MS structural verification
Form (free base vs salt) explicitly stated
Purity Testing
HPLC purity at 98%+ (achievable for a small molecule)
Single dominant peak
Contamination Testing
Heavy metals
Residual solvents
For capsules: microbial contamination, capsule integrity
30mg · sold research-use-only · we may earn a commission
Choosing the Right Format
Capsules vs Powder
Factor
Capsules
Raw Powder
Cost per 0.5mg dose
Mid ($1.67-6.00)
Lowest ($1.50-3.00)
Dose accuracy
High (fixed per cap)
Very low without sub-mg precision scale
Convenience
High
Very low (daily dose is 0.5mg = 0.0005g)
Travel-friendly
Yes
No
Common community pattern: Capsules at 0.5mg are the most-purchased format because the daily dose is too small for typical scales. Raw powder is rarely practical.
Bottle Size by Protocol
Tolerance testing (lower-end protocol at 0.25mg/day):
A 30ct × 0.25mg bottle is the smallest unit cited
~30-60 days of supply
Standard 0.5mg/day TIPO-1 protocol:
30ct × 0.5mg bottle — exactly 1 month
1 bottle per month
Extended protocols (24+ weeks):
60ct × 0.5mg bulk bottles at 10-15% better per-dose pricing
Vendor Evaluation Methodology
Price Competitiveness (40%)
Normalize to cost per 0.5mg dose.
COA & Testing (30%)
Third-party labs
Recent (within 6 months)
Mass spec confirming 327 Da
Reputation (30%)
Community feedback, shipping reliability.
Shipping and Storage
Storage Guidelines
Format
Temperature
Duration
Capsules
Room temp, dry
24+ months sealed
Raw powder
Room temp, sealed
24+ months
Where to Buy
1
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Frequently Asked Questions
Is tesofensine legal to buy?
Tesofensine is sold as a research chemical labeled 'not for human consumption.' It is an investigational drug in active clinical development (Phase 3 status in some indications) but is not FDA-approved. Purchasing research chemicals is legal in most US jurisdictions.
How much does tesofensine cost per month?
Community-cited oral protocols use 0.25-0.5mg/day. Monthly mass at 0.5mg/day is 15mg. Capsule bottles at 0.5mg × 30ct run $80-180. Monthly cost ranges from $80-180 depending on dose and format.
What format should I buy — capsules or powder?
Capsules are the most-cited format because the daily dose is small (0.25-1mg) and powder requires precision weighing at sub-milligram resolution. 0.5mg capsules are the most common variant.
What purity should I look for in tesofensine?
Third-party HPLC at 98%+ purity, plus mass spec confirming 327.27 Da (free base) or labeled salt form mass. Tesofensine is a small molecule (not peptide) — synthesis is straightforward at scale, so 99%+ purity is achievable.
What does the clinical data show?
The TIPO-1 Phase 2 trial in 203 obese patients (Astrup et al. 2008) showed 9.2% weight loss at 0.5mg/day vs 2% on placebo over 24 weeks. Tesofensine has progressed through additional Phase 2 work but is not yet FDA-approved.
Can I buy tesofensine from a pharmacy?
No. Tesofensine has not received FDA approval. Tesomet (combination tesofensine/metoprolol) has been studied for hypothalamic obesity but is not approved. Research vendors are the only documented commercial source.
This article is for educational and informational purposes only. It is not medical advice and should not be used to diagnose, treat, or prevent any condition. Consult a licensed healthcare provider before using any peptide.
