Weight Loss & Metabolic Peptides

GLP-1 & Incretin Peptide Pipeline Tracker

Dated, sourced status table and readout log for every GLP-1, GIP, glucagon and amylin compound in trials or approved, with every estimand labelled.

Roche's Enicepatide: 15.5% Weight Loss in Diabetes Trial

Roche's dual GLP-1/GIP shot cut weight 15.5% and HbA1c 2.65 points in type 2 diabetes — 62% hit non-diabetic blood sugar. What it means for buyers.

What Is Orforglipron (Foundayo)? Oral GLP-1 Pill

Orforglipron is the first oral GLP-1 pill, FDA-approved as Foundayo in 2026. How the once-daily tablet works, and why its weight loss trails injections.

Orforglipron: From Phase 1 Trials to FDA Approval

How orforglipron went from a 2023 Phase 1 readout to FDA approval as Foundayo — and why its ~12% weight loss trails injectable rivals.

What Doctors Think About Peptides: New Survey Data

48% of physicians say patients disclosed peptide use last year — and 84% got their information from influencers, not doctors. The full survey data.

What Is Bioglutide (NA-931)? Oral GLP-4 Agonist

Bioglutide (NA-931): the oral quadruple agonist adding IGF-1 to retatrutide's targets. What the ADA 2025 trial data reported, and the accessible analog.

EloraTZP Phase 2b: 23.3% Weight Loss in Type 2 Diabetes

Lilly's eloraTZP reported 23.3% weight loss vs 14.8% on tirzepatide alone in type 2 diabetes, but up to 27% stopped treatment. What Phase 2b showed.

Survodutide SYNCHRONIZE-2: 13.1% Loss in Type 2 Diabetes

Survodutide hit 13.1% weight loss in type 2 diabetes at 76 weeks in NEJM, but 18% quit over GI effects. How it compares with tirzepatide and semaglutide.

KAI-4729: New Triple Agonist Hits 16% in 12 Weeks

Kailera's KAI-4729, a retatrutide-style triple agonist, posted 16% weight loss and a 67% liver-fat drop in 12 weeks at EASD. What's actually sourceable.

ABBV-295: AbbVie Amylin Hits 9.8%, Eyes Monthly Dosing

AbbVie's amylin analog ABBV-295 reported up to 9.8% weight loss in 12 weeks, and a half-life that could support monthly dosing. What EASD 2026 showed.

Novo Pays $2.6B for HRS-1596 Weekly Oral GLP-1/GIP Pill

Novo paid $300M upfront for a weekly oral pill using tirzepatide's dual mechanism. What the $2.6B Hengrui deal signals, and what it changes for buyers.

Empower Pharmacy FDA Letter: The B12 Loophole Just Closed

The FDA told Empower Pharmacy its B12 and niacinamide GLP-1 add-ins are 'essentially copies.' What the letter says and where compounded supply goes now.

Vitamin B12 Injection Dosage: 1mg Protocol

The 1mg loading-then-maintenance schedule, oral vs injection evidence, methylcobalamin vs cyanocobalamin, and exact syringe units per vial size.

Bioglutide (NA-931) Dosage: What Trials Used

Bioglutide (NA-931) is oral, not injected. See the exact dose the Phase 2 trial used for 13.8% weight loss — and why no research-use protocol exists yet.

L-Carnitine Dosage: 500-2000 mg Protocols

Why oral L-carnitine is only ~15% absorbed, how injectable 500 mg/mL forms bypass that, and the 500-2000 mg/day ranges used across the clinical literature.

Retatrutide Stopped Working? Why Plateaus Happen

In Phase 2, retatrutide weight loss had still not plateaued at 48 weeks. Here is what the trial data, titration schedules and vial quality actually show.

Bioglutide (NA-931) Trial Results Timeline

Bioglutide (NA-931) trials reported up to 13.8% weight loss by week 13. How the oral quadruple agonist's results built across Phase 1 and Phase 2.

L-Carnitine Results Timeline: What to Expect

L-carnitine works on muscle stores, not blood levels — which is why recovery and fatigue effects take weeks, not days. Here's the documented timeline.

Vitamin B12 Results: Deficiency Timeline

Energy can shift in days, blood counts take weeks, nerves take months — and if you're not deficient, B12 does nothing. The honest timeline.

Tesofensine Results: Week-by-Week Timeline

Appetite suppression in days, weight loss over months. What the Phase 2 trial documented week 1 through month 6 at 0.5mg/day oral.

Survodutide Results: Week-by-Week Timeline

Appetite drops in week 1, but the 18.7% weight-loss figure took 46 weeks of titration. Full trial-reported timeline by phase and use case.

Retatrutide Precio: Dónde Comprar y Comparar

Compara el precio de retatrutide por mg entre proveedores: desde $45.50 el vial. Nura es el más barato en 10mg y 30mg. Tallas de vial, COA y coste por semana.

Dosis de Retatrutide: Tabla, Unidades y Titulación

Tabla completa de dosis de retatrutide con conversión exacta de mg a unidades — 0,25 mg, 0,5 mg y 1 mg desde un vial de 10 mg — más dosis iniciales de la comunidad.

Orforglipron Dosing: 0.8mg Oral Titration

The label starts orforglipron at 0.8mg once daily and steps up monthly to 17.2mg -- but Phase 3 trials used 6, 12 and 36mg. How the oral GLP-1 is dosed.

Buy Orforglipron: Price, COA & Cost Per Week

Only 1 vetted Orforglipron source right now: $198.95 a vial, $33.16/mg. Codes save up to 10%. COA status and real cost per week.

Retatrutide Cycle Protocol: Length, Taper, Off-Cycle

Community sources cluster around 8-on / 8-off. Covers cycle length, week-by-week titration, tapering, off-cycle reports, and restart protocols.

SLU-PP-332 Reconstitution: Vial Mixing & Oral Cap Notes

The 30 mg lyophilized vial reconstitutes to 10 mg/mL. Oral caps need no mixing — but the bioavailability question changes the math.

Switching Tirzepatide to Retatrutide: Dose & Washout

How long tirzepatide takes to clear, what retatrutide dose trials started at, and what weeks 1-8 look like. Trial data plus community-reported protocols.

Retatrutide vs Tirzepatide: What the Trials Show

Retatrutide hit 24% weight loss vs tirzepatide's 22.5% — but it also raises heart rate more, and the glucagon receptor is why. What the data shows.

Orforglipron vs Tirzepatide: Pill or Shot?

Orforglipron is a daily pill, tirzepatide a weekly shot — but trials show the injection lost nearly twice the weight. The honest tradeoff, side by side.

Orforglipron vs Retatrutide: Pill vs Injection

One's an FDA-approved pill; the other an injectable that hit 24% in trials. Oral scale vs peak power — the honest cross-trial comparison.

GLP-4 vs GLP-5: Bioglutide vs VRX-0075

Bioglutide (GLP-4) adds muscle-sparing IGF-1 and has oral human data; VRX-0075 (GLP-5) adds amylin for deeper loss but is rat-only. Full comparison.

Bioglutide vs Retatrutide: Oral Quad vs Injectable

Bioglutide (NA-931) is an oral quadruple agonist; retatrutide an injectable triple. How the two obesity compounds actually compare in 2026.

SLU-PP-332 vs MOTS-c: Two Exercise Mimetics

Synthetic ERR pan-agonist vs mitochondria-encoded AMPK activator. Same goal, opposite philosophies, and the stack rationale that ties them.

Cagri+Tirz vs Cagri+Sema: Amylin Pairing Choice

REDEFINE 1 hit 22.7% with cagrilintide + semaglutide. Cagrilintide + tirzepatide has stronger GIP. Mechanistic case, trial data, and the open question.

Where to Buy Bioglutide (NA-931): 2026 Status

Bioglutide (NA-931) isn't for sale yet — it's still in trials. See the real 2026 availability, why current listings aren't legit, and get launch alerts.

Buy L-Carnitine: Compare 2 Vendors, From $40

Compare 2 L-Carnitine vendors side by side: from $40 a vial, best value $0.01/mg. Codes save up to 15%. Vial sizes, COA status, real cost per week.

Buy Vitamin B12: Price, COA & Cost Per Week

Only one vetted Vitamin B12 source right now — its vial cost per mg, COA status, and real cost per week, checked.

Buy Survodutide: Price, COA & Cost Per Week

Only 1 vetted Survodutide source right now: $78 a vial, $7.80/mg. Codes save up to 10%. COA status and real cost per week.

Buy Cagrilintide: Compare 4 Vendors, From $44

Cagrilintide is the priciest weight-loss peptide per mg — so a vendor markup stings more here. The 10mg vial vs 5mg on cost, 4 vendors scored.

Peptide Stacks Under $200/Month

4 complete peptide protocols under $200/month — fat loss, healing, anti-aging, sleep. Per-peptide cost math, vendor picks, and which vial to buy.

Bioglutide (NA-931) Benefits: Oral, No Muscle Loss

Bioglutide (NA-931) is oral, once-daily. Phase 2 subjects on 150mg/day averaged 13.8% weight loss with no muscle loss reported. What the trial data shows.

L-Carnitine Benefits: Faster Recovery, Less Fatigue

The strongest L-carnitine evidence is exercise recovery and fatigue — not fat burning. See what trials actually show, including the modest weight effect.

Vitamin B12 for Nerve & Blood Health

The energy boost everyone cites is B12's weakest-evidenced benefit. What clinical trials actually show — anemia, nerves, homocysteine, cognition.

SLU-PP-332: Mice Lost 12% Body Weight in 30 Days

DIO mice on SLU-PP-332 ran 70% longer and gained 10x less fat than controls. What ERR pan-agonism does, plus the asterisks behind the data.

Retatrutide + Cagrilintide Benefits: 4 Pathways

GLP-1, GIP, glucagon, plus amylin — four metabolic axes in one stack. What the per-component trial data implies about combined effect.

Tirzepatide: 22.5% Weight Loss + Liver Fat

Weight loss gets the headlines, but tirzepatide's liver fat data may matter more. 8 research-backed effects with cited studies.

L-Carnitine Side Effects: What's Real

L-carnitine is well tolerated — but GI upset, a fishy body odor, and a debated TMAO–heart-risk signal are worth understanding before you buy.

Vitamin B12 Side Effects: What's Real

Vitamin B12 is one of the safest supplements there is — but injection reactions, acne flares, and a scary-sounding cancer signal are worth understanding.

5-Amino-1MQ Side Effects: What Research Shows

Animal models report clean safety. Community data adds mild GI and transient fatigue. Full breakdown of investigational dataset.

SLU-PP-332 Side Effects: Zero Human Data, Mouse Signals

SLU-PP-332 side effects: what mouse studies and ERR-receptor biology predict — cardiac and liver signals, plus the human unknowns no data rules out.

RetaCagri Side Effects: GI Burden + Dysesthesia

Both compounds slow gastric emptying via different pathways — combined nausea is the rate-limiter. Plus retatrutide's dysesthesia signal ≥9mg.

Tirzepatide Side Effects: 29% Nausea, When It Stops

29% of users get nausea at max dose — most resolves by week 4. Full safety breakdown: GI side effects, gastroparesis, thyroid flags, when to stop.

Retatrutide vs Semaglutide: Triple vs Single Agonist

Phase 2 trials reported 24.2% weight loss for retatrutide vs 14.9% for semaglutide in STEP 1 — but only one is FDA-approved. Full side-by-side.

Liraglutide vs Semaglutide: 2.5x Weight Loss Gap

STEP 8 head-to-head: 15.8% vs 6.4% weight loss. Side-by-side dosing, side effects, and cost — and which one to actually pick.

Cagrilintide vs Semaglutide: Different Paths

They target different receptors entirely — and combining them produces 22.7% weight loss. Mechanism, efficacy, and when to use each.

SLU-PP-332 + Retatrutide Stack: Eat Less, Burn More

Triple-agonist appetite suppression + ERR pan-agonist mitochondrial output. Why community references frame it as the cleanest mechanistic pair.

SLU-PP-332 Bloodwork: 7 Labs Researchers Track

Lactate may be the marker that tells you if ERR pan-agonism is doing anything. Cardiac, metabolic, and liver labs published preclinical work tracked.

Tirzepatide Bloodwork: 7 Labs to Track

Most skip calcitonin — the one marker that catches the rarest but most serious risk. 7 essential labs with optimal ranges and testing schedule.

Survodutide Bloodwork: 8 Labs to Track

Liver enzymes are the one most skip — and shouldn't with a glucagon agonist. 8 essential labs with optimal ranges and testing schedule.

5-Amino-1MQ Bloodwork: 8 Labs to Track

Most skip the insulin marker that shows if 5-amino-1MQ is working. 8 essential labs with optimal ranges, testing schedule, and what results mean.

$30 vs $300 Semaglutide: Where the Money Goes

Same Chinese factories, 10x price gap. We break down every dollar of compounded GLP-1 markup — what's real safety value vs telehealth marketing.