CJC-1295
A growth hormone peptide for fat loss, deeper sleep, and faster recovery. CJC-1295 (also known as Mod GRF 1-29) is a modified GHRH analog with four amino acid substitutions that improve stability. With a short ~30 minute half-life, it mimics natural pulsatile GH release patterns. Often combined with GHRPs like Ipamorelin for synergistic effects.
Compare Prices🧬Key Characteristics
- Position 2: Ala → D-Ala(Helps prevent enzymatic cleavage.)
- Position 8: Asn → Gln(Helps prevent chemical rearrangement.)
- Position 15: Gly → Ala(Can enhance receptor binding strength.)
- Position 27: Met → Leu(Helps reduce oxidation damage.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
CJC-1295 Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
GHRH Analog (Growth Hormone Releasing Hormone)Sequence → Stability → GH Pattern → Outcomes
GHRH Receptor on Pituitary Somatotrophs
CJC-1295 (no DAC) binds the GHRH receptor on pituitary somatotroph cells — the same receptor targeted by Sermorelin and Tesamorelin. This is the "starter signal" that tells your body to release growth hormone.
cAMP → PKA Cascade → GH Vesicle Release
Receptor activation triggers the cAMP → PKA signaling cascade inside pituitary cells. This causes stored growth hormone to be released in pulses — not a constant drip, but bursts that mimic your body's natural rhythm.
Pulsatile GH → Liver IGF-1 → Metabolic Cascade
GH pulses travel to the liver and other tissues, stimulating IGF-1 production and triggering downstream metabolic effects: fat mobilization, protein synthesis, tissue repair, and cellular regeneration.
Sleep → Recovery → Body Composition → Vitality
Improved sleep quality is often the first effect noticed (weeks 1-2). Faster recovery and gradual fat loss follow over months. Skin elasticity, hair quality, and overall vitality improve with sustained use. Benefits build gradually — GH optimization is a slow, cumulative process.
What Makes This Peptide Different
CJC-1295 (no DAC) is essentially Sermorelin — GHRH(1-29) — with 4 targeted amino acid substitutions engineered to resist enzymatic breakdown. Same receptor, same signaling cascade, but the modifications keep the short fragment intact longer in the body. The ~30 minute half-life still produces natural pulsatile GH release, unlike the DAC version which sustains GH for days.
Sequence → Why It Matters
CJC-1295 retains the core active region of GHRH(1-29) with 4 engineered changes to reduce enzymatic breakdown:
So what? Same receptor target as Sermorelin, but engineered to keep the short 1-29 fragment intact long enough to reliably signal. The result: a more consistent GH pulse window compared to unmodified Sermorelin, without the sustained (non-pulsatile) elevation caused by the DAC version.
GHRH Peptide Comparison
| Peptide | Half-Life | GH Pattern | What's Unique |
|---|---|---|---|
| Sermorelin | ~10-20 min | Short, natural pulse | Native GHRH(1-29) — no modifications, shortest duration |
| CJC-1295 (no DAC) | ~30 min | Broader natural pulse | 4 substitutions for stability — more reliable signaling window |
| Tesamorelin | ~26-38 min | Reliable, broader pulse | Full 44-AA GHRH + hexenoic acid — FDA-approved for visceral fat |
| CJC-1295 (DAC) | 6-8 days | Sustained elevation | Albumin binding — convenience, but non-pulsatile GH |
Dosing Protocol
Growth Hormone / LongevityEducational reference only. Individual responses vary. Consult healthcare provider before use.
Popular Stack Protocols
1 stackCommonly paired protocols from the peptide research community. Educational reference only.
🧬 CJC-1295 + Ipamorelin
Growth Hormone / Fat Loss / Anti-AgingWhy This Dosing Protocol
Why before bed? Your largest natural GH pulse occurs ~1 hour after falling asleep. Injecting CJC-1295 before bed amplifies this existing pulse rather than creating an artificial one, working with your circadian biology.
Why empty stomach? Food (especially carbs) triggers insulin release, which blunts GH secretion. A 2+ hour fast before injection ensures insulin is low when the GH pulse fires.
Why 5 days on / 2 days off? Prevents receptor desensitization. The 2-day break allows GHRH receptors to resensitize, maintaining response over longer protocols.
Diagrams
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CJC-1295 Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
5 mg / vial
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10 mg / vial
In-stock offersOut of stock (1)
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Stacks
CJC-1295 is commonly paired with ipamorelin in GH-axis research discussions. For comparing bundles fairly, we normalize stack value using the CJC-1295 amount as the driving peptide (assuming ratios remain consistent as bundle sizes scale).
CJC-1295 + Ipamorelin
Bundle of CJC-1295 (GHRH analog) and Ipamorelin (ghrelin-receptor secretagogue) often paired in GH-axis research discussions.
| Vendor | Stack | Price | $/mg (CJC) | COA | Link |
|---|---|---|---|---|---|
| EZ Peptides | 5mg/5mg | $44.00 | $8.80 | Go → | |
| Certified Pep | 10mg/10mg | $110.00 | $11.00 | Go → | |
| Certified Pep | 5mg/5mg | $60.00 | $12.00 | Go → | |
| Ascension Peptides | 5mg | $100.00 | $20.00 | Go → | |
| Limitless Biotech | 6mg | $156.99 | $26.17 | Go → |
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorHandling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What are the most common side effects?
Most peptides cause mild injection site reactions, temporary water retention, and possible joint discomfort. CJC-1295 (no DAC) has minimal impact on cortisol and prolactin levels compared to other GH peptides.
Why do people stack CJC-1295 with Ipamorelin?
This combination works synergistically—CJC-1295 (GHRH pathway) increases the number of cells releasing GH, while Ipamorelin (GHRP pathway) increases GH release per cell. Together they produce stronger results with minimal side effects.
What is CJC-1295 and how does it work?
CJC-1295 is a synthetic analog of growth hormone releasing hormone (GHRH). It stimulates the pituitary gland to produce and release growth hormone. The "no DAC" version has a half-life of about 30 minutes, producing pulsatile GH release that mimics natural patterns.
What is the difference between CJC-1295 and CJC-1295 with DAC?
CJC-1295 (no DAC) has a ~30 minute half-life and produces natural pulsatile GH release. CJC-1295 with DAC (Drug Affinity Complex) binds to albumin, extending half-life to 6-8 days and creating sustained GH elevation. No DAC is preferred for mimicking natural GH patterns; DAC for convenience.
What is the typical CJC-1295 dosage?
A common research dosage for CJC-1295 (no DAC) is 200 mcg per injection, taken once daily before bed on an empty stomach (5 days on, 2 days off). It's often combined with a GHRP like Ipamorelin at similar doses. Bedtime dosing amplifies the natural nighttime GH pulse.
What benefits does CJC-1295 provide?
By elevating GH and IGF-1 levels, CJC-1295 may support fat loss, lean muscle growth, improved sleep quality, faster recovery, enhanced skin health, and general anti-aging effects. Benefits develop gradually over weeks to months of consistent use.
How long until CJC-1295 shows results?
Initial effects like improved sleep quality may be noticed within 1-2 weeks. Body composition changes (fat loss, muscle gain) typically take 2-3 months. Skin and recovery improvements develop over 3-6 months. Patience and consistency are key — GH works gradually.
Is CJC-1295 better than synthetic HGH?
CJC-1295 stimulates your body's natural GH production rather than replacing it. This preserves natural feedback mechanisms and pulsatile release patterns. It's generally considered safer with fewer side effects than exogenous HGH, though effects may be more subtle. It's also significantly less expensive.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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