CJC-1295 with DAC
A long-acting growth hormone peptide for fat loss, lean muscle, and anti-aging. CJC-1295 with DAC (Drug Affinity Complex) is a long-acting GHRH analog that binds to albumin, extending its half-life to 6-8 days. This allows for less frequent dosing compared to CJC-1295 without DAC, providing sustained GH elevation rather than pulsatile release.
Compare Prices🧬Key Characteristics
- Length: 30 amino acids(Modified GRF(1-29) + DAC.)
- Half-life: 6-8 days(vs. 30 min for CJC-1295 no DAC.)
- Mechanism: GHRH agonist(Sustained GH elevation.)
- Dosing: 1-2x weekly(Less frequent than no-DAC version.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
CJC-1295 with DAC Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
GHRH Analog — Long-Acting (Drug Affinity Complex)Sequence → Stability → GH Pattern → Outcomes
GHRH Receptor on Pituitary Somatotrophs
Same receptor as CJC-1295 (no DAC), Sermorelin, and Tesamorelin. The critical difference is duration of action — the DAC modification causes the peptide to bind albumin in the blood, keeping it active for 6-8 days.
Sustained cAMP/PKA Activation → Continuous GH Elevation
Rather than triggering discrete GH pulses, the long half-life creates sustained GH elevation (sometimes called "GH bleed"). The pituitary is continuously stimulated rather than pulsed, which differs from natural GH secretion patterns.
Steady GH/IGF-1 Elevation → Consistent Anabolic Signal
Sustained GH leads to consistently elevated IGF-1 levels. This provides a more constant anabolic environment but lacks the peaks and troughs of natural pulsatile release. Some researchers believe pulsatile patterns are more physiologically effective.
Convenience + Steady-State Effects
Weekly dosing convenience is the primary advantage. Effects are similar to other GHRH analogs — sleep, recovery, body composition — but the sustained release pattern may produce different quality of results compared to pulsatile versions. Water retention is more common.
What Makes This Peptide Different
CJC-1295 with DAC is the same modified GRF(1-29) base as CJC-1295 (no DAC), but with a Drug Affinity Complex that covalently binds to serum albumin. This extends the half-life from ~30 minutes to 6-8 days. The tradeoff: convenience (1-2 injections per week) vs. non-pulsatile GH elevation that doesn't mimic natural patterns. Many prefer the no-DAC version for physiological reasons despite the daily dosing requirement.
GHRH Peptide Comparison
| Peptide | Half-Life | GH Pattern | What's Unique |
|---|---|---|---|
| CJC-1295 (no DAC) | ~30 min | Natural pulsatile | Pulsatile release — more physiological, requires daily dosing |
| CJC-1295 (DAC) | 6-8 days | Sustained elevation | Albumin binding — weekly dosing, non-pulsatile "GH bleed" |
| Sermorelin | ~10-20 min | Brief natural pulse | Native GHRH(1-29) — most natural, least stable |
| Tesamorelin | ~26-38 min | Reliable pulse | Full 44-AA — FDA-approved for visceral fat reduction |
Dosing Protocol
Growth Hormone / LongevityEducational reference only. Individual responses vary. Consult healthcare provider before use.
Popular Stack Protocols
1 stackCommonly paired protocols from the peptide research community. Educational reference only.
🧬 CJC-1295 DAC + Ipamorelin
Growth Hormone / Sustained ReleaseWhy This Dosing Protocol
Why weekly dosing? The DAC modification extends half-life to 6-8 days. A single injection provides sustained GH elevation throughout the week — no need for daily dosing.
Why some prefer no-DAC instead: The sustained GH elevation ("GH bleed") doesn't mimic natural pulsatile patterns. Some researchers believe the peaks and troughs of pulsatile release are more effective for fat loss and recovery. DAC trades physiological signaling for dosing convenience.
Diagrams
Hover for preview • Click to open full size
CJC-1295 with DAC Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
5 mg / vial
In-stock offersOut of stock (1)
Looking for medical guidance?
Join the waitlist for doctor-guided peptide plans. We'll notify you when telehealth consultations are available in your state.
Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
CJC-1295 with Dac vs no Dac
CJC-1295 with Dac Dosage
CJC-1295 with Dac Reconstitue
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What are the most common side effects?
Most peptides cause mild injection site reactions, temporary water retention, and possible joint discomfort. CJC-1295 with DAC has minimal impact on cortisol and prolactin levels compared to other GH peptides.
Why do people stack CJC-1295 with Ipamorelin?
This combination works synergistically—CJC-1295 (GHRH pathway) increases the number of cells releasing GH, while Ipamorelin (GHRP pathway) increases GH release per cell. Together they produce stronger results with minimal side effects.
What is DAC and why does it matter?
DAC (Drug Affinity Complex) is a modification that allows CJC-1295 to bind to albumin in the blood. This extends the half-life from ~30 minutes to 6-8 days, meaning weekly injections instead of daily. The tradeoff is that it creates sustained GH elevation rather than natural pulsatile release.
Is CJC-1295 with DAC better than without DAC?
Neither is objectively "better" — they have different use cases. DAC version offers convenience (1-2 injections per week) but causes sustained GH elevation. No-DAC version requires daily dosing but produces more natural pulsatile GH patterns. Many prefer no-DAC for physiological reasons; DAC for simplicity.
What is the typical CJC-1295 DAC dosage?
Common research dosages range from 1-2 mg per week, often as a single weekly injection or split into two doses. Due to the long half-life, more frequent dosing isn't necessary. Some use it with a GHRP like Ipamorelin on non-injection days to add pulsatile release.
Does CJC-1295 DAC cause GH bleed?
Yes, the sustained release creates what's called "GH bleed" — consistently elevated GH rather than natural spikes. Some researchers believe pulsatile release is healthier and more effective. This is a key reason some prefer the no-DAC version despite the inconvenience of daily dosing.
What benefits does CJC-1295 DAC provide?
By elevating GH and IGF-1 levels, CJC-1295 DAC may support fat loss, muscle growth, improved sleep, faster recovery, and anti-aging effects. The sustained release may be particularly effective for consistent IGF-1 elevation. Results develop over weeks to months.
Can CJC-1295 DAC be combined with GHRPs?
Yes, many combine weekly CJC-1295 DAC with daily GHRP injections (like Ipamorelin). This provides baseline sustained GH elevation from the DAC plus natural pulsatile spikes from the GHRP. This approach tries to get benefits of both release patterns.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.
Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
Disclosure: we may earn affiliate commission from qualifying purchases. Educational information only — not medical advice.