CJC-1295 No DAC: 200mcg PM, 5-On/2-Off

CJC-1295 no DAC (also known as modified GRF 1-29) is a synthetic GHRH analog with four amino acid substitutions for improved stability and a short-acting ~30-minute half-life that produces pulsatile GH release mimicking the body's natural secretion pattern. No human clinical trials exist for the no-DAC form. Community protocols are based on GHRH pharmacology and the DAC version's clinical data. This is not medical advice.

Quick Reference: Standard Protocol

The standard protocol is 200 mcg before bed, 5 days on / 2 days off, for 8 weeks. CJC-1295 no DAC is almost always paired with a GHRP (ipamorelin, GHRP-2, or GHRP-6) for synergistic GH release. Standalone use produces modest results.

For the full CJC-1295 peptide profile, vendor pricing, and stack protocols, see our CJC-1295 peptide page.

Cycling: 8 Weeks On, 8 Weeks Off

Run 200 mcg before bed, 5 days on / 2 days off, for 8 weeks. Then take 8 weeks off to allow natural GH axis recovery. No loading phase needed. IGF-1 blood work before, during, and after cycles helps gauge response.

Flushing and head rush are common in the first 1-2 weeks and typically resolve.

PM timing is critical: The pre-bed injection amplifies the natural nocturnal GH surge -- the largest GH pulse of the day. Inject on an empty stomach. Carbohydrates and fats suppress GH release via insulin and somatostatin.

Routes of Administration

Subcutaneous injection (standard): Abdomen, love handles, or thighs. Very small injection volume (typically 0.05-0.06 mL). 29-31 gauge insulin syringe. Rotate sites to prevent lipodystrophy.

Reconstitution Quick Reference

Math: 10,000 mcg / 3 mL = 3,333 mcg/mL. For 200 mcg: 200 / 3,333 = 0.06 mL = 6 units. One vial lasts 50 doses.

Swirl gently -- do not shake. Refrigerate at 2-8°C and use within 28 days. For step-by-step instructions, see the CJC-1295 Reconstitution Guide.

Where These Numbers Come From

CJC-1295 clinical research primarily used the DAC version, but the pharmacology informs no-DAC protocols.

Pivotal human study: Teichman et al. examined CJC-1295 (with DAC) in 36 healthy adults (21-61 years). Single doses of 30-120 mcg/kg produced dose-dependent GH and IGF-1 increases, with IGF-1 elevated 1.5-3 fold for 6-14 days (Teichman et al., 2006).

Preserved pulsatility: A follow-up confirmed that despite continuous GHRH stimulation, pulsatile GH secretion was maintained -- GH pulse frequency preserved with 2-fold increases in mean GH and pulse mass (Ionescu & Bhatt, 2006).

Animal studies: CJC-1295 normalized growth in GHRH knockout mice with once-daily dosing (Alba et al., 2006).

Why no-DAC is preferred by many: Short half-life produces pulsatile rather than sustained GH elevation, more closely mimicking natural GHRH/GH secretion. Lower baseline GH between pulses. Controllable timing windows. Optimal synergy with timed GHRP co-injection.

Stacking Protocols

Stacking tips: Always inject GHRH + GHRP simultaneously for synergistic effect. Both can be drawn into one insulin syringe. Fasted state critical. Pre-bed injection is the most important timing window.

For the detailed blend protocol, see our CJC-1295 + Ipamorelin Dosing Guide.

Side Effects & Safety

• Flushing/warmth -- very common in first 1-2 weeks, transient (15-30 min post-injection)
• Head rush/dizziness -- brief, typically resolves quickly
• Injection site reactions -- mild redness, occasional irritation
• Water retention -- mild, GH-mediated sodium retention
• Tingling/numbness -- occasional, related to GH effects
• Vivid dreams -- frequently reported, likely from enhanced deep sleep
• Insulin resistance -- chronic GH elevation can impair glucose tolerance (monitor fasting glucose)
• Contraindications -- active malignancy, diabetic retinopathy, pregnancy

Frequently Asked Questions

What is the standard CJC-1295 no DAC dose?

200 mcg subcutaneous before bed (PM), 5 days on / 2 days off, for 8 weeks on / 8 weeks off. Use a 10 mg vial with 3 mL BAC water -- 200 mcg is 6 units. Almost always combined with a GHRP like ipamorelin.

What's the difference between CJC-1295 with and without DAC?

Without DAC: ~30-minute half-life, pulsatile GH release, mimics natural pattern. With DAC: ~8-day half-life, sustained GH elevation, weekly injection, more convenient but less physiological.

Should I take CJC-1295 no DAC alone?

It works alone but produces modest results. Pairing with a GHRP (ipamorelin is most popular) produces 5-10x greater GH release through synergistic receptor activation.

When should I inject CJC-1295 no DAC?

Before bed (PM) on an empty stomach. This amplifies the natural nocturnal GH surge. Wait at least 20-30 minutes after your last meal.

How long does a CJC-1295 no DAC cycle last?

8 weeks on, 8 weeks off, with a 5-on/2-off weekly pattern. Monitor IGF-1 to confirm response.

What results can I expect?

Improved sleep quality (1-2 weeks), gradual fat loss (4-8 weeks), improved recovery, better skin quality, and modest body composition improvements. Effects are subtle and cumulative.

Related Guides

• CJC-1295 Peptide Page -- Full profile, vendor pricing, and comparisons
• CJC-1295 + Ipamorelin Dosing Guide -- Detailed stack protocol
• CJC-1295 DAC Dosing Guide -- Long-acting version with weekly dosing
• CJC-1295 DAC vs No DAC -- Head-to-head comparison
• CJC-1295 Reconstitution Guide -- Step-by-step mixing and dilution charts
• CJC-1295 Results Timeline -- Week-by-week expectations for DAC and no-DAC
• CJC-1295 Bloodwork Guide -- What labs to track
• Ipamorelin Dosing Guide -- Primary GHRP pairing partner
• GHRP-2 Dosing Guide -- Higher-potency GHRP for aggressive stacks
• Calculate Your CJC-1295 Cycle Cost -- estimate vials needed and total cost for your protocol
• Best Peptides for Muscle Growth (2026) -- all 10 muscle-building peptides ranked

References

For educational and research purposes only. This is not medical advice. CJC-1295 without DAC has no human clinical trials. Community protocols are based on GHRH pharmacology and the DAC version's clinical data.