GHRP-6
A growth hormone peptide with strong appetite stimulation — ideal for bulking. GHRP-6 is the original growth hormone releasing peptide, a synthetic hexapeptide that strongly stimulates GH release through the ghrelin receptor. Known for significant appetite stimulation (hunger effect within 20-30 minutes), making it popular for bulking phases and hardgainers who need to increase caloric intake.
Compare Prices🧬Key Characteristics
- Length: 6 amino acids(Hexapeptide structure.)
- Half-life: ~15-30 minutes(Short duration requires multiple daily doses.)
- Receptor: GHS-R (ghrelin)(Strong ghrelin mimetic activity.)
- Appetite: Strong increase(Most hunger-inducing GHRP — useful for hardgainers.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
GHRP-6 Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
GHRP (Growth Hormone Releasing Peptide) — Strong Ghrelin AgonistReceptor → GH Secretion → Systemic Effects → Outcomes
GHS-R1a (Ghrelin Receptor) — Broad Activation
GHRP-6 is the original GHRP, activating the ghrelin receptor with broad downstream effects. It produces strong GH release but also strongly activates the appetite pathway — a feature that's either a benefit or drawback depending on goals.
IP3/DAG + Strong Central Ghrelin Signaling
Beyond GH release, GHRP-6 strongly stimulates central ghrelin pathways that control hunger. This causes significant appetite increase within 20-30 minutes of injection. Also elevates cortisol and prolactin more than Ipamorelin.
Strong GH + Appetite → Anabolic Environment
The combination of elevated GH/IGF-1 plus increased caloric intake creates a powerful anabolic environment. This makes GHRP-6 particularly effective for bulking and muscle gain when combined with a training program and sufficient nutrition.
Significant Hunger → Muscle Growth → Recovery
Strong appetite increase is the most immediate and noticeable effect (20-30 min post-injection). Recovery improvements, sleep quality, and body composition changes follow over weeks. Ideal for hardgainers who struggle to eat enough.
What Makes This Peptide Different
GHRP-6's defining feature is its strong appetite stimulation. While Ipamorelin avoids hunger effects and GHRP-2 causes moderate appetite increase, GHRP-6 creates significant hunger — making it the go-to for bulking phases and hardgainers. Also the most affordable GHRP, making it accessible for longer protocols.
GHRP Comparison — Selectivity vs Potency
| Peptide | Half-Life | GH Pattern | What's Unique |
|---|---|---|---|
| Ipamorelin | ~2 hours | Selective GH pulse | Most selective — no cortisol/prolactin/hunger |
| GHRP-2 | ~15-30 min | Strong GH pulse | Potent + moderate appetite — good middle ground |
| GHRP-6 | ~15-20 min | Strong GH pulse | Significant appetite — ideal for bulking, most affordable |
| Hexarelin | ~70 min | Strongest GH pulse | Most potent but rapid desensitization |
Dosing Protocol
Growth Hormone / AppetiteEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why AM and/or PM? Same dual GH window approach as other GHRPs. The strong appetite effect post-injection makes morning dosing useful for those wanting to increase caloric intake.
Why empty stomach? Critical for GHRP-6 — both to avoid insulin interference with GH release, and because the hunger spike is most useful when you haven't eaten (drives a large meal post-injection).
Diagrams
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GHRP-6 Pricing
We surface in-stock offers first and normalize by price per mg for quick comparisons.
5 mg / vial
In-stock offers10 mg / vial
In-stock offersOut of stock (1)
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorEducational Videos
How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
Why does GHRP-6 cause such strong hunger?
GHRP-6 is a strong ghrelin mimetic — it activates the same receptors as the hunger hormone ghrelin. This causes significant appetite increase, typically within 20-30 minutes of administration. This effect makes it popular for bulking phases or those who struggle to eat enough calories.
How does GHRP-6 compare to GHRP-2?
Both have similar GH-releasing potency, but GHRP-6 causes stronger hunger increase. GHRP-6 also tends to raise cortisol slightly more. Choose GHRP-6 if appetite stimulation is desired (bulking, hardgainers); choose GHRP-2 if you want potency without as much hunger.
What are the main side effects of GHRP-6?
The most notable side effect is intense hunger (can occur 20-30 min post-injection). Other effects include water retention, tingling sensations, cortisol/prolactin elevation, and potential blood sugar fluctuations. The hunger effect diminishes somewhat with continued use.
Is GHRP-6 good for building muscle?
GHRP-6 can support muscle growth through GH elevation, but its real advantage is appetite stimulation. For hardgainers who struggle to eat enough, the hunger effect helps achieve the caloric surplus needed for muscle growth. Combined with proper training and nutrition, it can support lean mass gains.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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