Hexarelin
The strongest growth hormone-releasing peptide for serious muscle and recovery goals. Hexarelin is one of the most potent GHRPs (Growth Hormone Releasing Peptides), producing strong GH pulses through the ghrelin receptor. More potent than GHRP-6 but with greater effects on cortisol and prolactin. Often used in research for its powerful GH-releasing properties.
Compare Prices🧬Key Characteristics
- Length: 6 amino acids(Hexapeptide structure.)
- Potency: Very high(Among the strongest GHRPs available.)
- Half-life: ~15-30 minutes(Short duration, multiple daily doses.)
- Desensitization: Can occur(May need cycling to maintain response.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
Hexarelin Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
GHRP (Growth Hormone Releasing Peptide) — Strongest GHRPReceptor → GH Secretion → Systemic Effects → Outcomes
GHS-R1a (Ghrelin Receptor) — Maximum Activation
Hexarelin is the most potent GHRP available, producing the strongest GH release per dose. It activates the ghrelin receptor more intensely than GHRP-2 or GHRP-6, but this maximum stimulation comes with a key limitation: rapid receptor desensitization.
Maximum IP3/DAG Activation → Peak GH Output
The intense ghrelin receptor activation produces the highest GH spikes of any GHRP. However, the aggressive stimulation causes GHRH receptors to downregulate faster than with milder GHRPs. This is why Hexarelin cycles must be kept short (4-8 weeks max).
Peak GH/IGF-1 → Rapid but Time-Limited Results
The high GH output produces strong IGF-1 elevation and robust anabolic effects, but diminishing returns set in faster than other GHRPs. Hexarelin also has notable cardioprotective properties — it binds CD36 receptors on cardiac tissue, potentially protecting against ischemic damage.
Strong Initial Effects → Diminishing Over Weeks
Pronounced effects on sleep, recovery, and body composition in the first 2-4 weeks. Effects typically plateau or diminish by weeks 4-6 due to desensitization. Best used in short, intense cycles with adequate off-time between cycles.
What Makes This Peptide Different
Hexarelin is the most potent but shortest-cycle GHRP. While Ipamorelin can be run for extended periods with minimal desensitization, Hexarelin's aggressive receptor activation causes diminishing returns after 4-6 weeks. It also has unique cardioprotective properties via CD36 receptor binding — a mechanism not shared by other GHRPs.
GHRP Comparison — Selectivity vs Potency
| Peptide | Half-Life | GH Pattern | What's Unique |
|---|---|---|---|
| Ipamorelin | ~2 hours | Selective GH pulse | Most selective — long cycles, minimal desensitization |
| GHRP-2 | ~15-30 min | Strong GH pulse | Potent — moderate desensitization over time |
| GHRP-6 | ~15-20 min | Strong GH pulse | Strong hunger — ideal for bulking phases |
| Hexarelin | ~70 min | Strongest GH pulse | Most potent — short cycles only (4-8 weeks), cardioprotective |
Dosing Protocol
Growth HormoneEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why shorter cycles (4-8 weeks)? Hexarelin's intense receptor activation causes desensitization faster than other GHRPs. Limiting cycles to 4-8 weeks with extended off-periods preserves receptor sensitivity for future use.
Why lower doses (100-200 mcg)? Hexarelin is potent enough that higher doses don't proportionally increase GH release but do accelerate desensitization. Conservative dosing extends the effective window.
Diagrams
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Hexarelin Pricing
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5 mg / vial
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
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How to Reconstitute Peptides
Handling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
How potent is Hexarelin compared to other GHRPs?
Hexarelin is considered one of the most potent GHRPs for stimulating GH release. However, this potency comes with stronger effects on cortisol and prolactin compared to milder options like Ipamorelin. It may also cause desensitization with prolonged use.
What is Hexarelin and how does it work?
Hexarelin is a synthetic growth hormone releasing peptide (GHRP) that stimulates the pituitary gland to release growth hormone. It works by binding to ghrelin receptors (GHS-R1a), mimicking the hunger hormone ghrelin. It's a 6-amino acid peptide and one of the strongest GHRPs available.
Does Hexarelin cause desensitization?
Yes, Hexarelin can cause receptor desensitization with prolonged continuous use, reducing its effectiveness over time. This is more pronounced than with other GHRPs like Ipamorelin. Many protocols recommend cycling (e.g., 8-12 weeks on, 4 weeks off) or using lower doses to minimize desensitization.
What are the side effects of Hexarelin?
Common side effects include water retention, increased appetite, tingling/numbness in extremities, and elevated cortisol and prolactin levels. The cortisol and prolactin effects are more pronounced than with Ipamorelin. Some users experience lethargy, headaches, or vivid dreams. Most effects are dose-dependent.
What is the typical Hexarelin dosage?
Research dosages typically range from 100-300 mcg per injection, administered 1-3 times daily on a 5 days on, 2 days off schedule (8 weeks on, 8 weeks off). Due to its potency, many start at the lower end. Shorter cycles (4-8 weeks) may be preferred due to desensitization concerns.
Can Hexarelin be stacked with other peptides?
Yes, Hexarelin is commonly stacked with GHRH peptides like CJC-1295 for synergistic GH release. The combination amplifies the GH pulse more than either alone. It's not typically stacked with other GHRPs since they work on the same receptor. Some use it in rotation with milder GHRPs.
Does Hexarelin have cardioprotective effects?
Research suggests Hexarelin may have cardioprotective properties independent of GH release. Studies show it can protect heart cells from ischemia and may improve cardiac function. These effects appear to be mediated through cardiac ghrelin receptors (GHS-R1a) rather than GH elevation.
How does Hexarelin affect hunger?
Hexarelin increases appetite by activating ghrelin receptors, though typically less intensely than GHRP-6. The hunger effect usually occurs 20-30 minutes post-injection and subsides within a few hours. This can be beneficial for bulking phases but may be unwanted during cutting.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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Scientific Sources
The following peer-reviewed studies and official resources provide additional scientific context for this peptide:
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