PT-141

bremelanotideLyophilized powder

PT-141 (bremelanotide) is a melanocortin receptor agonist, derived from Melanotan II, that acts in the brain rather than on blood flow. Bremelanotide is FDA-approved as a prescription treatment for hypoactive sexual desire disorder in premenopausal women; the research-grade vials listed here are a different, unapproved product. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$2.80/mg · lot PT1-062026-1 · 99.81% · In stock

Price

$28.00

List

$40.00

Buy 10 mg at Nura Peptide

Price shown uses code thepeptidecatalog at Nura Peptide's checkout (30% off list).

Sold by Nura Peptide as PT-141 10mg. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

PT-141 research vial sold by Nura Peptide as PT-141 10mg
Third-party tested≥99.81% reported purityResearch use only
Certificate of AnalysisLot PT1-062026-1 · 99.81%View
  • Certificate of Analysis published for every lot (Freedom Diagnostics Testing)
  • Current lots report 99.81% purity or higher
  • Ships from a U.S. fulfillment center, per Nura Peptide
  • Lyophilized powder · laboratory research use only
Research-context information only. PT-141 is the active ingredient in FDA-approved products for hypoactive sexual desire disorder in premenopausal women; research-peptide and compounded forms are not FDA-approved and are sold for research purposes only. Protocols, doses, and reactions reported below come from clinical trials and community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

PT-141 Vial Sizes, Prices & Lots

PT-141 vial sizes, prices and lots at Nura Peptide
SizeListWith our codePer mgAvailabilityLot · purity
10 mg$40.00$28.00$2.80In stockPT1-062026-1 · 99.81%

Prices checked today, 6:20 AM CT on Nura Peptide's site, with code thepeptidecatalog applied. Lot data from Nura Peptide's COA page, checked today, 8:15 PM CT. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Verified test results

PT-141 Certificate of Analysis

Nura Peptide publishes a third-party certificate for each lot of PT-141 10mg. The figures below are copied from Nura Peptide's current-lot listings, checked today, 8:15 PM CT (refreshed hourly; hidden if older than 24 hours). Match the lot number on the vial to its certificate.

All lots on record: Nura Peptide COA library. How to check one: how to verify a peptide COA.

PT-141 Dosing in Clinical Research

Sexual Health / Libido

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
10 mg
Reconstitution
2 ml BAC water
Dose
500 mcg (10 units on 1ml syringe)
Timing
30 minutes before sexual activity
Frequency
As needed
Duration
As needed
Protocol Notes
FDA-approved as Vyleesi (at 1.75 mg) for HSDD in women. Works centrally via MC3R/MC4R receptors. Common side effects: nausea, flushing, headache.

Why This Dosing Protocol

Why as-needed? PT-141 is used for acute episodes, not daily maintenance. The 45-minute onset allows planning ahead.

Why max once per 24 hours / 8x per month? Melanocortin receptor desensitization occurs with frequent use. Limiting frequency preserves efficacy and reduces side effects. Also, PT-141 can transiently increase blood pressure.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator

How PT-141 Works

Melanocortin Agonist — MC3R/MC4R Selective (Sexual Function)

Receptor → Central Arousal Pathway → Sexual Desire → Outcomes

1
Target

MC3R/MC4R (Central Melanocortin Receptors)

PT-141 (Bremelanotide) selectively activates MC3R and MC4R receptors in the brain — the same receptors responsible for Melanotan-2's libido effects, but without significant MC1R activation (minimal tanning effect).

2
Cellular Signal

Central MC3R/MC4R → Dopaminergic Sexual Arousal Pathway

Melanocortin receptor activation in the hypothalamus triggers dopamine release in areas involved in sexual arousal and desire. Unlike PDE5 inhibitors (Viagra), which work on blood flow only, PT-141 works on desire and arousal centrally.

3
Systemic Effect

Central Sexual Arousal → Desire + Physical Response

Increased sexual desire and arousal through central brain mechanisms. Works in both men and women. FDA-approved for hypoactive sexual desire disorder (HSDD) in women as Vyleesi. Different mechanism than PDE5 inhibitors — addresses desire rather than just physical function.

4
What You Notice

Increased Desire (45 min onset) + Possible Nausea/Flushing

Increased sexual desire and arousal typically within 45 minutes. Common side effects: nausea (40%+), flushing, headache. These side effects are from melanocortin receptor activation and typically diminish with experience. Effects last several hours.

What Makes This Peptide Different

PT-141 is the only FDA-approved peptide for sexual desire. Derived from Melanotan-2 research, it isolates the MC3R/MC4R sexual function effects while minimizing tanning. Unlike Viagra (blood flow), PT-141 works on brain-based desire and arousal — a fundamentally different mechanism that works in both sexes.

PT-141 Clinical Evidence

Two parallel grades per outcome — clinical RCT depth and real-world community adoption. See the Research Overview below for citations and detail.

OutcomeClinical EvidenceCommunity Evidence
Female HSDD (premenopausal)StrongModerate
Long-term safety in womenStrongModerate
Erectile function (off-label)ModerateModerate

PT-141 Research Overview

Outcome-by-outcome look at what the evidence actually supports for PT-141, including human vs. animal study counts and our editorial take on each.

Hypoactive sexual desire disorder (women)

Clinical:StrongCommunity:Moderate

Kingsberg 2019 (RECONNECT, n=1267 across two Phase 3 trials) randomized premenopausal women with acquired generalized HSDD to bremelanotide 1.75 mg SC PRN vs placebo for 24 weeks and showed significant improvements in desire and reduction in distress. FDA-approved 2019 (Vyleesi) — the second drug ever approved for female HSDD.

3 human studies · 6 animal studies

Key findings & citations
  • RECONNECT: significant improvement in FSFI desire domain and FSDS-DAO item 13 vs placebo.
  • Effect on satisfying sexual events was small (~0.5 events/month).
  • Nausea ~40% — primary reason for discontinuation.
  • Long-term 52-week extension confirmed safety profile (Simon 2019).

Our take

Approved drug with real but modest effect. Nausea is the primary reason most patients won't continue past a few doses.

Erectile function (off-label)

Clinical:ModerateCommunity:Moderate

PT-141 was originally developed for ED — Phase 2 work in the early 2000s showed pro-erectile effects, but Palatin pivoted to female HSDD due to BP elevation in male studies. Off-label use in men persists in community practice without a male-indication-specific Phase 3 program.

2 human studies · 6 animal studies

Key findings & citations
  • Early Phase 2 pro-erectile effects in men.
  • Development pivoted to female HSDD due to systolic BP elevation in men.
  • No FDA approval for male ED — off-label use only.

Our take

Works in men, but the BP signal is the reason it's not approved for ED. Use with caution in hypertensive users.

What PT-141 doesn't do

Claims that current evidence does not support. Worth knowing before you set expectations.

Technical specifications

PT-141 chemical & analytical data

Also known as
bremelanotide
Sold by Nura Peptide as
PT-141 10mg
Receptor targets
Melanocortin 3/4 receptors (MC3R, MC4R)
Backbone length
5 amino acids
Modifications
Cyclic structure (lactam); D-Phe at position 7; N-terminal acetylation
Half-life (clinical PK)
~2 hours
Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
10 mg
Purity on current lots (COA)
99.81%
Testing laboratory
Freedom Diagnostics Testing
Regulatory status
Active ingredient in FDA-approved prescription products; research-grade vials are not FDA-approved.

PT-141 Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

8 answers

PT-141 FAQ: Buying, COA, Storage & Research

What is PT-141 and how does it work?
PT-141 (Bremelanotide) is a synthetic peptide that activates melanocortin receptors (MC3R and MC4R) in the brain. Unlike Viagra or Cialis which increase blood flow, PT-141 works centrally to increase sexual desire and arousal. It was derived from Melanotan II and is FDA-approved under the brand name Vyleesi for treating hypoactive sexual desire disorder (HSDD) in premenopausal women.
How is PT-141 different from Viagra?
Viagra (sildenafil) and similar PDE5 inhibitors work by increasing blood flow to enhance physical response. PT-141 works in the brain on melanocortin receptors to increase sexual desire itself. This makes PT-141 effective for people whose issue is low libido rather than physical arousal problems. PT-141 can work for both men and women, while Viagra is only approved for men.
What are the side effects of PT-141?
The most common side effect is nausea, which affects about 40% of users. Other side effects include flushing, headache, and injection site reactions. PT-141 can cause transient increases in blood pressure, so it's not recommended for people with uncontrolled hypertension or cardiovascular disease. The FDA recommends no more than 8 doses per month.
How long does PT-141 take to work?
PT-141 is typically administered about 45 minutes before anticipated sexual activity. Effects can last for several hours. Unlike daily medications, it's used on an as-needed basis. Most users report effects beginning within 30-60 minutes of injection, with peak effects occurring around 1-2 hours.
Is PT-141 FDA approved?
Yes, PT-141 (as Vyleesi/bremelanotide) received FDA approval in June 2019 for treating hypoactive sexual desire disorder (HSDD) in premenopausal women. It's the first FDA-approved treatment that targets brain pathways for sexual desire. It's administered as a subcutaneous injection via an autoinjector pen.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

PT-141 Studies & Sources

The following peer-reviewed studies and official resources provide additional scientific context for this peptide:

PT-141 Research Articles

guides

PT-141 Dosage Chart: 500mcg On-Demand Protocol

Timing matters more than dose — too early and effects fade. Covers 500mcg starting dose, FDA data, and nausea management.

side-effects

PT-141 Side Effects: Nausea, Flushing, BP Changes

Nausea hits 40% of Phase 3 participants. Flushing and BP elevation follow. Full FDA-label safety breakdown.

guides

Buy PT-141: Compare 5 Vendors, From $37

A 10mg PT-141 vial is several doses — so the cheapest sticker can be the pricier shot. Per-mg across 5 vendors, which COAs to trust, and cost per dose.

results

PT-141 Results: What to Expect & When

First effects hit in 15-30 minutes — but nausea often arrives first. Realistic timeline from dose one through repeated use.

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