Pinealon

Lyophilized powder

Pinealon is a Khavinson short-peptide bioregulator, the tripeptide Glu-Asp-Arg (EDR), studied in cell and rodent models of neuroprotection. It has no human clinical trials. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$2.50/mg · In stock

Price

$25.00

List

$89.99

Buy 10 mg at Ascension Peptides

Price shown includes the 50% discount Ascension Peptides applies through our link.

Volume pricing at Ascension Peptides

  • 3+ vials3% offin cart
  • 5+ vials5% offin cart
  • 10+ vials10% offin cart

Applied in Ascension Peptides's cart; how it combines with our discount is set at checkout.

Sold by Ascension Peptides. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

Pinealon research vial
PinealonAscension Peptides
Third-party testedResearch use only
Certificate of AnalysisVendor-stated: Third-party tested · HPLC · public COAView
  • Vendor-stated testing: Third-party tested · HPLC · public COA
  • Listed on our pinealon vendor comparison, ordered by our vendor rankings
  • Lyophilized powder · laboratory research use only
Research-context information only. Pinealon is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

Pinealon Vial Sizes & Prices

Pinealon vial sizes, prices and lots at Ascension Peptides
SizeListPricePer mgAvailability
10 mg$89.99$25.00$2.50In stock

Prices checked today, 5:03 AM CT on Ascension Peptides's site. Vendor-stated testing: Third-party tested · HPLC · public COA. The lot certificate is on Ascension Peptides's product page. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Test results

Pinealon Certificate of Analysis

Ascension Peptides publishes its certificates publicly (vendor-stated: Third-party tested · HPLC · public COA). Match the lot number on the vial to its certificate.

View the Pinealon certificate on Ascension Peptides's product page.

How to check one: how to verify a peptide COA.

Pinealon Dosing in Clinical Research

Neuroprotection (Research / No Human Data)

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
10 mg
Reconstitution
1 ml BAC water (10 mg/ml)
Dose
5-10 mg (50-100 units) — community convention, not a trial dose
Timing
AM
Frequency
Once daily
Duration
Short 10-20 day courses (community convention)
Protocol Notes
Khavinson tripeptide bioregulator (Glu-Asp-Arg / EDR). There is no human-trial dose — figures shown are community conventions anchored to the single 10mg vial size. Evidence is preclinical cell-culture and rodent only.

Why This Dosing Protocol

What dose do people use? The 5-10 mg/day figures circulating online are community conventions anchored to the single 10 mg vial size, not trial-derived numbers.

Why short courses? Community use mirrors the short-pulse administration of Khavinson-program bioregulators in preclinical work — convention by analogy, not a tested Pinealon protocol.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator

How Pinealon Works

Short-Peptide Bioregulator — Neuro / Epigenetic (Preclinical Evidence Only)

Target → Signal → Effect → Outcomes

1
Target

Neuronal Chromatin / Gene Promoters

Pinealon is the tripeptide Glu-Asp-Arg(EDR), one of the short "peptide bioregulators" from the Khavinson research program. The leading hypothesis is that this small, charged peptide enters the cell and interacts with promoter regions of specific genes — a proposed epigenetic mechanism modeled in docking and cell-culture work, not confirmed in humans.

2
Cellular Signal

Reduced Oxidative Stress & Apoptosis

In cultured neurons under oxidative stress, Pinealon produced a dose-dependent reduction in reactive-oxygen-species accumulation and decreased necrotic cell death. Mechanistic papers model it as nudging transcription of neuroprotective and apoptosis-related genes. These are in-vitro and modeling findings — a plausible cellular signal, not a validated human pathway.

3
Systemic Effect

Neuroprotection (Animal Models)

The closest thing to a whole-organism effect is rodent: in offspring exposed to prenatal oxidative stress, Pinealon administration was associated with improved spatial learning and lower neuronal oxidative stress. That is a developmental animal model — there is no human systemic outcome data at all.

4
What You Notice

Unknown in Humans

Honestly, there is no human evidence to predict what a person would notice. The measured effects were cellular and behavioral in animals, not subjective human experiences. "No perceptible change" is fully consistent with the absence of human efficacy data.

What Makes This Peptide Different

Pinealon is not a validated drug — it is a research tripeptidefrom the Khavinson bioregulator framework, marketed as a neuroprotective "brain peptide." What distinguishes it is the proposed epigenetic mechanism (a short peptide acting at gene promoters) — an intriguing idea backed mostly by cell-culture and rodent work from a single group, with no human trials, no FDA evaluation, and no established dose.

Technical specifications

Pinealon chemical & analytical data

Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
10 mg
Regulatory status
Research peptide; research-grade vials are not FDA-approved.

Pinealon Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

7 answers

Pinealon FAQ: Buying, COA, Storage & Research

What is Pinealon (EDR)?
Pinealon is a synthetic tripeptide — Glu-Asp-Arg, also written EDR — from the Russian "peptide bioregulator" research program associated with Vladimir Khavinson. It is marketed as a neuroprotective brain peptide. In preclinical work it reduced reactive oxygen species and neuronal cell death and was modeled as a regulator of gene expression. There are no human clinical trials, no FDA evaluation, and no established dose.
How strong is the evidence behind Pinealon?
Thin and early. The published data is preclinical — cell-culture and rodent studies — and most of it comes from a single research group. A 2011 study reported reduced ROS and necrotic cell death in neurons (Khavinson et al.), and a 2012 rodent study reported improved learning in offspring exposed to prenatal oxidative stress (Arutjunyan et al.). No human trial has confirmed any cognitive or neuroprotective benefit in people.
Is there a proven Pinealon dose?
No. Because there are no human trials, there is no validated dose. Community protocols describe roughly 5-10 mg per day subcutaneously in short 10-20 day courses, but those figures are conventions shaped by the single 10 mg vial size — not dose-finding data.
Does Pinealon improve sleep, like its 'pineal' name suggests?
There is no human evidence that Pinealon improves sleep or melatonin rhythms. Despite the name, the published research centers on neuronal oxidative stress and gene-expression modeling, not sleep architecture. Any sleep claim is unsupported by the available data.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

Pinealon Research Articles

dosing

Pinealon Dosage: What the Research Shows

There's no human-trial dose for Pinealon. Community protocols cluster at 5-10mg/day in short courses — here's the math and where the numbers come from.

results

Pinealon Results: What to Expect & When

There's no human timeline for Pinealon — only preclinical data and community reports. What that evidence actually suggests over a short course.

reconstitution

Pinealon Reconstitution: 10mg + 1mL Chart

At 10mg/mL, a community-documented 5mg draw is exactly 50 units. Most mixing errors happen at the syringe math. Pinealon dilution chart, storage, and steps.

guides

Buy Pinealon: Compare 3 Vendors, From $49.99

Compare 3 Pinealon vendors side by side: from $49.99 a vial, best value $2.90/mg. Codes save up to 50%. Vial sizes, COA status, real cost per week.

Compare Pinealon Vendors Before You Buy

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