VIP

vasoactive intestinal peptideLyophilized powder

VIP (vasoactive intestinal peptide) is a 28-amino-acid neuropeptide found throughout the gut, lungs and brain, with roles in blood-vessel relaxation and immune regulation. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$2.90/mg · In stock

Price

$29.00

List

$58.00

Buy 10 mg at Ascension Peptides

Price shown includes the 50% discount Ascension Peptides applies through our link.

Volume pricing at Ascension Peptides

  • 3+ vials3% offin cart
  • 5+ vials5% offin cart
  • 10+ vials10% offin cart

Applied in Ascension Peptides's cart; how it combines with our discount is set at checkout.

Sold by Ascension Peptides. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

VIP research vial
VIPAscension Peptides
Third-party testedResearch use only
Certificate of AnalysisVendor-stated: Third-party tested · HPLC · public COAView
  • Vendor-stated testing: Third-party tested · HPLC · public COA
  • Listed on our vip vendor comparison, ordered by our vendor rankings
  • Lyophilized powder · laboratory research use only
Research-context information only. VIP is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

VIP Vial Sizes & Prices

VIP vial sizes, prices and lots at Ascension Peptides
SizeListPricePer mgAvailability
10 mg$58.00$29.00$2.90In stock

Prices checked today, 5:01 AM CT on Ascension Peptides's site. Vendor-stated testing: Third-party tested · HPLC · public COA. The lot certificate is on Ascension Peptides's product page. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Test results

VIP Certificate of Analysis

Ascension Peptides publishes its certificates publicly (vendor-stated: Third-party tested · HPLC · public COA). Match the lot number on the vial to its certificate.

View the VIP certificate on Ascension Peptides's product page.

How to check one: how to verify a peptide COA.

VIP Dosing in Clinical Research

CIRS Treatment / Immune Regulation

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
5 mg
Reconstitution
5 ml BAC water
Dose
50 mcg (5 units on 1ml syringe)
Timing
AM and PM
Frequency
Every day
Duration
8 weeks on, 8 weeks off
Protocol Notes
Vasoactive intestinal peptide — used in CIRS and mold illness protocols. Can also be used intranasally. Monitor inflammatory markers during treatment.

Why This Dosing Protocol

Why nasal spray? VIP nasal spray provides direct access to nasal and pulmonary mucosa — key target tissues in CIRS. Also provides some CNS access for neuroprotective effects.

Why the Shoemaker sequence? VIP is the final step in CIRS treatment because it requires prior steps (binder therapy, MARCoNS treatment) to be completed first. Using VIP before clearing biotoxins can worsen symptoms.

Why 30-day minimum? Immune rebalancing is a gradual process. VIP needs consistent exposure over weeks to shift immune cell phenotypes from inflammatory to regulatory.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator

How VIP Works

Neuropeptide — Immunomodulator / Vasodilator

Receptor → Immune Rebalancing → Systemic Recovery → Outcomes

1
Target

VPAC1/VPAC2 Receptors (Immune Cells, Neurons, Vasculature)

VIP (Vasoactive Intestinal Peptide) activates VPAC1 and VPAC2 G-protein coupled receptors distributed widely across immune cells, neurons, pulmonary vasculature, and the GI tract. This broad receptor distribution underlies VIP's diverse effects on immunity, inflammation, and vascular function.

2
Cellular Signal

cAMP/PKA → Anti-Inflammatory + Vasodilatory Cascade

VPAC receptor activation increases intracellular cAMP, which shifts immune cells from pro-inflammatory (Th1/Th17) toward regulatory (Treg) phenotypes. In vasculature, cAMP causes smooth muscle relaxation and vasodilation. In neurons, it provides neuroprotective signaling.

3
Systemic Effect

Immune Rebalancing + Vasodilation + Neuroprotection

Shifts the immune system from inflammatory to regulatory mode — critical for CIRS (Chronic Inflammatory Response Syndrome) and mold illness. Reduces pulmonary artery pressure. Supports circadian rhythm regulation through SCN (suprachiasmatic nucleus) signaling. Protects neurons from inflammatory damage.

4
What You Notice

Reduced Inflammation → Breathing Improvement → Energy

In CIRS patients: reduced inflammatory markers (C4a, TGF-β1, MMP-9), improved breathing, and increased energy over weeks to months. Central to the Shoemaker protocol as the final step in CIRS treatment. Also used for pulmonary hypertension and neuroinflammatory conditions.

What Makes This Peptide Different

VIP is uniquely positioned at the intersection of immune, vascular, and neural systems. While Thymosin Alpha-1 enhances adaptive immunity and KPV targets inflammation, VIP rebalances the entire immune response while also addressing vascular and neurological components. The Shoemaker protocol established it as the gold-standard final treatment for CIRS/mold illness.

VIP Clinical Evidence

Two parallel grades per outcome — clinical RCT depth and real-world community adoption. See the Research Overview below for citations and detail.

OutcomeClinical EvidenceCommunity Evidence
Pulmonary sarcoidosisModerateWeak
Pulmonary hypertension / lung inflammationWeakWeak
Erectile dysfunction (intracavernosal Invicorp)ModerateWeak

VIP Research Overview

Outcome-by-outcome look at what the evidence actually supports for VIP, including human vs. animal study counts and our editorial take on each.

Pulmonary sarcoidosis (inhaled VIP)

Clinical:ModerateCommunity:Weak

Prasse 2010 (open Phase 2, n=20) treated patients with histologically proven sarcoidosis with nebulized VIP for 4 weeks and showed safe, well-tolerated reduction in TNF-α production by bronchoalveolar lavage cells along with subjective cough and dyspnea improvement. This is the first human study to demonstrate VIP's immunoregulatory effect — but it is small, open-label, and a single-trial finding.

1 human study · 12 animal studies

Key findings & citations
  • Prasse 2010: TNF-α reduction in BAL cells from 20 sarcoidosis patients on inhaled VIP.
  • Subjective cough and dyspnea improvement reported.
  • Open-label, n=20 — would need a properly controlled Phase 2/3 to confirm.
  • VIP has very short systemic half-life — local pulmonary delivery is essential.

Our take

Single-trial signal in a niche indication. Community use as an injectable systemic peptide doesn't match the route of the only positive clinical study.

What VIP doesn't do

Claims that current evidence does not support. Worth knowing before you set expectations.

Technical specifications

VIP chemical & analytical data

Also known as
vasoactive intestinal peptide
Receptor targets
VPAC1 / VPAC2 receptors
Backbone length
28 amino acids
Modifications
C-terminal amidation; 28-residue vasoactive intestinal peptide
Half-life (clinical PK)
~2 minutes
Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
10 mg
Regulatory status
Research peptide; research-grade vials are not FDA-approved.

VIP Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

8 answers

VIP FAQ: Buying, COA, Storage & Research

What is CIRS and how does VIP treat it?
CIRS (Chronic Inflammatory Response Syndrome) is a multi-system illness triggered by biotoxin exposure — most commonly from water-damaged buildings (mold). VIP is the final step in the Shoemaker protocol, used after other inflammatory markers (C4a, TGF-β1, MMP-9, VEGF) have been corrected. It rebalances the immune system from pro-inflammatory (Th1/Th17) to regulatory (Treg) responses.
Why is VIP administered as a nasal spray?
Intranasal delivery targets both the respiratory tract (relevant for CIRS lung inflammation and pulmonary hypertension) and the CNS via the olfactory pathway. It avoids first-pass liver metabolism and provides rapid local effects. The standard formulation is 50 mcg per spray, typically dosed 4 times daily.
What lab markers should be monitored during VIP therapy?
Key markers include: C4a (complement activation), TGF-β1 (fibrosis/immune dysregulation), MMP-9 (tissue remodeling), VEGF (vascular growth), MSH (melanocyte-stimulating hormone), and VIP levels themselves. Pulmonary artery pressure should also be monitored via echocardiogram. VIP should only be started after these markers are trending toward normal from earlier protocol steps.
Can VIP be used for conditions other than CIRS?
Research has explored VIP for pulmonary arterial hypertension, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative conditions. Its role as a neuropeptide means it also regulates circadian rhythms (via the suprachiasmatic nucleus) and protects neurons from inflammatory damage. However, CIRS treatment remains its most established clinical application.
What are the side effects of VIP?
VIP is generally well-tolerated at therapeutic doses. Some patients report mild nasal irritation, transient flushing, or loose stools (VIP stimulates intestinal secretion — it's called "vasoactive intestinal peptide" for a reason). Rarely, excessive doses can cause hypotension due to vasodilation. Monitoring by a CIRS-literate physician is recommended.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

VIP Research Articles

guides

VIP Dosage Chart: 50mcg SubQ AM/PM Protocol

VIP is the final step in the Shoemaker protocol — using it too early backfires. Covers 50mcg SubQ, intranasal CIRS dosing, and cycling.

reconstitution

VIP Reconstitution: 5mg + 5mL Chart

50mcg = 5 units at 1mg/mL. The mix differs for SubQ vs intranasal — dilution charts, syringe math, and nasal-spray prep, step by step.

side-effects

VIP Side Effects: 7 to Watch For

Transient hypotension hits most VIP users — but lipase elevation is the one to actually monitor. Full safety breakdown by frequency.

guides

Buy VIP: Compare 4 Vendors, From $58

Compare 4 VIP vendors side by side: from $58 a vial, best value $5.80/mg. Codes save up to 50%. Vial sizes, COA status, real cost per week.

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