FOXO4-DRI
A senolytic peptide that selectively eliminates damaged zombie cells for anti-aging. FOXO4-DRI is a D-retro-inverso peptide that selectively eliminates senescent (zombie) cells by disrupting the FOXO4-p53 interaction. This senolytic mechanism triggers apoptosis specifically in damaged cells while sparing healthy ones. A cutting-edge anti-aging research compound based on the landmark 2017 Cell paper.
Compare Prices🧬Key Characteristics
- Design: D-retro-inverso(All-D amino acids, reversed sequence.)
- Target: FOXO4-p53 complex(Disrupts senescent cell survival.)
- Selectivity: Senescent cells only(Healthy cells unaffected.)
- Key Study: Baar et al. 2017 (Cell)(Restored fitness in aged mice.)
Overview
Core Benefits
Key AdvantagesThese are educational summaries of commonly discussed effects in wellness/regenerative contexts, not guarantees.
FOXO4-DRI Results Timeline
ProgressionTimeline is illustrative and non-guaranteed. Outcomes vary and are commonly discussed alongside training, nutrition, sleep, and cycling practices.
How It Works
Senolytic Peptide — Selective Senescent Cell EliminatorTarget → Senescent Cell Clearance → Tissue Rejuvenation → Outcomes
FOXO4-p53 Interaction in Senescent Cells
FOXO4-DRI is a D-retro-inverso peptide that specifically disrupts the interaction between FOXO4 and p53 proteins inside senescent ("zombie") cells. In these damaged cells, FOXO4 sequesters p53 in the nucleus, preventing it from triggering apoptosis. FOXO4-DRI breaks this protective interaction.
p53 Release → Mitochondrial Apoptosis Cascade
By displacing FOXO4 from p53, the freed p53 translocates to mitochondria and triggers the intrinsic apoptosis pathway — specifically in senescent cells where this FOXO4-p53 interaction is uniquely present. Healthy cells don't rely on this mechanism, so they are spared.
Senescent Cell Clearance → Reduced SASP → Tissue Rejuvenation
Senescent cells secrete the SASP (Senescence-Associated Secretory Phenotype) — inflammatory cytokines that damage surrounding tissue and accelerate aging. Removing these cells reduces chronic inflammation and allows healthy tissue to regenerate. Mouse studies showed restored fitness, kidney function, and fur density.
Gradual Anti-Aging Effects → Vitality → Tissue Improvement
Effects are cumulative and gradual. Reduced inflammation markers over weeks. Improved tissue function in areas with high senescent cell burden. This is a cutting-edge research compound — no human clinical trials yet. Based on the landmark 2017 Cell paper by Baar et al.
What Makes This Peptide Different
FOXO4-DRI is the most targeted senolytic available — it exploits a vulnerability unique to senescent cells (the FOXO4-p53 nuclear sequestration). Unlike broad senolytics (dasatinib + quercetin) that affect multiple pathways, FOXO4-DRI's D-retro-inverso design makes it protease-resistant while maintaining the specific protein-protein disruption. The selectivity for senescent cells is its key advantage.
Dosing Protocol
Senolytic / Anti-AgingEducational reference only. Individual responses vary. Consult healthcare provider before use.
Why This Dosing Protocol
Why intermittent dosing? Senolytic therapy doesn't require continuous treatment. Senescent cells accumulate slowly — periodic clearance (hit-and-run approach) is the standard strategy. Short intensive courses followed by long breaks.
Why the D-retro-inverso design? Normal peptides are rapidly degraded by proteases. The DRI modification uses D-amino acids in reverse order, creating a mirror-image peptide that resists enzymatic breakdown while maintaining biological activity.
FOXO4-DRI Pricing
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10 mg / vial
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Reconstitution calculator
Dilution math and unit conversions. Prefilled using a common vial size for this peptide.
Open calculatorHandling
Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.
- Freezer (-20°C): 1+ year ✓
- Refrigerator (2-8°C): 1-3 months ✓
- Room temperature: 2-3 weeks (emergency only)
- MUST refrigerate at 2-8°C
- 4-week maximum shelf life
- NEVER freeze after reconstitution
- Use bacteriostatic water for multi-dose
Storage & Handling Guide
Learn proper storage temperatures, shelf life timelines, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.
FAQ
What are senescent cells and why are they harmful?
Senescent cells are damaged cells that stop dividing but refuse to die. They accumulate with age and secrete a toxic cocktail of inflammatory molecules called SASP (senescence-associated secretory phenotype). This chronic inflammation drives aging, tissue dysfunction, and age-related diseases. Clearing these "zombie cells" is the goal of senolytic therapies.
How does FOXO4-DRI selectively target senescent cells?
In senescent cells, the FOXO4 protein binds p53 to prevent apoptosis — keeping the damaged cell alive. FOXO4-DRI competes with endogenous FOXO4 for p53 binding, freeing p53 to trigger the cell's self-destruct program. Healthy cells don't depend on FOXO4-p53 binding for survival, so they're unaffected.
What does D-retro-inverso mean?
D-retro-inverso (DRI) is a peptide engineering technique where the amino acid sequence is reversed and all L-amino acids are replaced with D-amino acids. This makes the peptide highly resistant to proteases (enzymes that break down proteins) while preserving the spatial orientation needed for biological activity. It dramatically extends the peptide's half-life.
What did the original FOXO4-DRI mouse study show?
The landmark 2017 Baar et al. study in Cell showed that FOXO4-DRI restored fitness, fur density, and kidney function in naturally aged mice. It also counteracted chemotherapy-induced senescence. Treated mice showed reduced senescent cell burden and decreased SASP markers without apparent toxicity to healthy tissues.
How is FOXO4-DRI different from dasatinib + quercetin?
Dasatinib + quercetin (D+Q) are broad-spectrum senolytics that affect multiple anti-apoptotic pathways — effective but less selective. FOXO4-DRI specifically disrupts only the FOXO4-p53 survival mechanism unique to senescent cells. This targeted approach may have fewer off-target effects, though D+Q has more human clinical data and is far cheaper (they're repurposed drugs).
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
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