The tesamorelin/ipamorelin blend is the dual-pathway growth-hormone-releasing combination — tesamorelin acts on GHRH receptors (Falutz et al. 2007, the pivotal Phase III HIV lipodystrophy trial) while ipamorelin selectively activates the ghrelin receptor (Raun et al. 1998). Combined, they produce a larger GH pulse than either alone — same theoretical synergy as CJC-1295/ipamorelin but with tesamorelin's stronger clinical-data base behind the GHRH arm.
Research-context information only. Tesamorelin is the active ingredient in an FDA-approved product for HIV-associated lipodystrophy; research-peptide and compounded forms are not FDA-approved and are sold for research purposes only. Ipamorelin is a research peptide on the FDA 503A bulks Category 2 list. Protocols, doses, and reactions reported below come from clinical trials and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.
The buying problem is that tesamorelin is one of the most-counterfeited research peptides — vendors substitute cheaper sermorelin (3,358 Da, ~$2-3/mg) for tesamorelin ($6-15/mg). The blend version makes verification harder because per-component COA is required.
This guide covers documented per-mg pricing, blend COA verification, ratio selection, and red flags. For dosing context, see the tesamorelin/ipamorelin dosing guide.
The blend ships as a single lyophilized vial. Most vendors offer 12mg total (10mg tesamorelin + 2mg ipamorelin, a 5:1 ratio). Some boutique vendors offer 6mg total (4mg + 2mg, a 2:1 ratio).
Current Market Pricing (2026)
Vial Size
Typical Price Range
Price Per Total mg
Best For
6mg blend (4+2)
$50-100
$8-17/mg
Tolerance testing
12mg blend (10+2)
$90-180
$7.50-15/mg
Standard 1mg/day tesa + 200mcg ipa — best all-around
12mg × 5 (kit)
$400-800
$6.67-13.33/mg
Extended cycles
The pattern: 12mg blends are the most-cited size in vendor catalogs. Per-total-mg cost is higher than CJC-1295/ipamorelin blends because tesamorelin synthesis is more expensive than CJC-1295.
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How to Verify Tesamorelin/Ipamorelin Quality
The per-component COA challenge for this blend is harder than most because tesamorelin is structurally similar to sermorelin and CJC-1295 — all three are GHRH analogs with overlapping HPLC behavior. Mass spec is non-negotiable.
What a Blend COA Should Include
Identity Confirmation — Both Peptides
Mass spec confirming tesamorelin at 5,196 Da (44-residue GHRH analog with N-terminal hexenoyl modification)
Mass spec confirming ipamorelin at 711.85 Da
Per-peptide amino acid sequence verification
Tesamorelin's hexenoyl modification specifically verified — this distinguishes it from sermorelin (3,358 Da, no hexenoyl)
Purity Testing — Both Peptides
HPLC purity at 98%+ for each peptide individually
Two HPLC chromatograms, each showing a single dominant peak
Contamination Testing
Endotoxin levels
Residual solvent analysis
Heavy metals screening
How to Verify a Blend COA Is Legitimate
Two separate test reports — per-peptide mass spec and HPLC, not a combined "blend purity"
The 14-21 Day Stability Rule (Tesamorelin's Tighter Window)
Tesamorelin reconstituted with bacteriostatic water and refrigerated is documented stable for roughly 14-21 days — shorter than the 28 days for ipamorelin. The blend takes the more conservative stability number, so the operating window is 14-21 days reconstituted.
Vial Size
At 1mg+200mcg/day
At 2mg+200mcg/day
At 0.5mg+200mcg/day
6mg blend
5 days
2.5 days
~8 days
12mg blend
10 days
5 days
~17 days ⚠️
⚠️ = at the edge of the 14-21 day stability window
Practical implication: A 12mg blend at standard 1mg+200mcg/day fits the stability window cleanly. At lower doses (0.5mg + 200mcg/day), the vial pushes the window edge — staged reconstitution or smaller 6mg vials are common.
Vial Size by Protocol
Tolerance testing:
A 6mg blend vial is the smallest unit cited
2.5-8 days at standard doses
Standard 1mg+200mcg/day community protocol:
12mg blend vial — lasts 10 days, well within stability window
3 vials per month at this dose
The most-cited size in vendor sales data
Phase III 2mg/day tesamorelin protocol:
12mg blend at 2mg+200mcg/day = 5 days per vial
6 vials per month — kit pricing meaningful here
Buying Multiple Smaller vs Kit
Factor
Multiple 12mg Singles
Kit (5× 12mg)
Cost per total mg
Higher ($7.50-15/mg)
Lower ($6.67-13.33/mg)
Freshness
Same (lyophilized storage)
Same
Flexibility
Can stop mid-cycle
Committed to full kit
Storage
Easier (smaller volumes)
Requires fridge space
Shipping
More frequent orders
Single shipment
Why This Blend Costs More Than CJC-1295/Ipamorelin
A common question: tesamorelin/ipamorelin runs $7.50-15/mg total vs $5-9/mg for CJC-1295/ipamorelin. Three reasons:
1. Tesamorelin is a longer peptide. 44 residues vs 29 residues for CJC-1295 no-DAC. Solid-phase peptide synthesis cost scales with chain length.
2. Hexenoyl modification adds synthesis cost. Tesamorelin's trans-3-hexenoic acid N-terminal modification requires a specialized synthesis step that CJC-1295 doesn't need.
3. Stronger clinical data base. Tesamorelin has Phase III RCT data; CJC-1295 does not. The premium reflects evidence quality, not just synthesis cost.
For users who tolerate the cost premium and prioritize evidence quality, tesamorelin/ipamorelin is the documented option. For users prioritizing per-mg cost, CJC-1295/ipamorelin remains the budget alternative.
Vendor Evaluation Methodology
When comparing tesamorelin/ipamorelin blend vendors:
Price Competitiveness (40%)
Normalize to cost per total milligram. 12mg blend at $130 ($10.83/mg) scores higher than 12mg at $180 ($15/mg).
COA & Testing (30%)
Per-peptide reports (separate mass spec and HPLC)
Third-party labs (Janoshik, MZ Biolabs, Colmaric)
Recent (within 6 months)
Verifiable task number
Both molecular weights confirmed (5,196 Da AND 711.85 Da)
Reputation (30%)
Community feedback, shipping reliability, customer service, multi-year track record. Tesamorelin specifically has a counterfeit history — vendor reputation is heavily weighted here.
Shipping and Storage
Order Arrival
Lyophilized blend typically arrives as a single white or off-white powder cake:
Vial integrity — no cracks, intact rubber seal, aluminum cap secure
Powder appearance — solid cake or loose powder, NOT liquid or discolored
Labeling — batch/lot, total mg content, ratio (e.g., "10mg + 2mg"), "for research use only"
Cold pack — most reputable vendors include cold packs in summer (especially important for tesamorelin)
Storage Guidelines
State
Temperature
Duration
Lyophilized (powder)
Room temp
Days only (shipping)
Lyophilized (powder)
Refrigerated (2-8°C)
12+ months
Lyophilized (powder)
Frozen (-20°C)
24+ months
Reconstituted (BAC water)
Refrigerated (2-8°C)
~14-21 days (tesamorelin's tighter window)
Reconstituted (sterile water)
Refrigerated (2-8°C)
~24 hours
Reconstituted
Frozen
Not generally recommended (degrades hexenoyl modification)
Where to Buy
1
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Frequently Asked Questions
Is tesamorelin/ipamorelin blend legal to buy?
Tesamorelin is the active ingredient in an FDA-approved product for HIV-associated lipodystrophy. Ipamorelin is on the FDA 503A bulks Category 2 list. Both peptides are sold by research vendors as research chemicals labeled 'not for human consumption.' Purchasing research peptides is legal in most US jurisdictions.
How much does tesamorelin/ipamorelin blend cost per month?
A 12mg blend vial (10mg tesamorelin + 2mg ipamorelin) typically runs $90-180. At standard community protocols of 1mg tesa + 200mcg ipa daily, one vial lasts ~10 days. Monthly cost runs $270-540 at full daily dosing.
Is the blend cheaper than buying tesamorelin and ipamorelin separately?
Yes, by roughly 15-25%. Buying 10mg tesamorelin (~$80-150) + 2mg ipamorelin (~$15-30) separately runs $95-180 total. A 12mg blend with the same mass runs $90-160 — modest savings, plus reduced reconstitution complexity.
What ratio is in a tesamorelin/ipamorelin blend?
The most common ratio is 5:1 (e.g., 10mg tesa + 2mg ipa) or 2:1 (e.g., 4mg tesa + 2mg ipa). Tesamorelin is the dose-active component (1-2mg/day in trials), while ipamorelin is dosed in the 100-300mcg range. Verify the ratio on the COA.
What purity should I look for in a tesa/ipa blend?
Per-component HPLC at 98%+ purity for both peptides individually. Mass spec must confirm 5,196 Da (tesamorelin) and 711.85 Da (ipamorelin). The tesamorelin verification is critical — sermorelin (~3,358 Da) is the most common substitution.
Can I buy tesamorelin/ipamorelin blend from a compounding pharmacy?
Tesamorelin has an FDA-approved branded version, so compounding is restricted. Ipamorelin is on the 503A Category 2 list, prohibiting compounding. Research vendors are the documented option for buyers in this category.
This article is for educational and informational purposes only. It is not medical advice and should not be used to diagnose, treat, or prevent any condition. Consult a licensed healthcare provider before using any peptide.
