CJC-1295 with DAC

Lyophilized powder

CJC-1295 with DAC is a growth hormone-releasing hormone (GHRH) analog fitted with a Drug Affinity Complex that binds albumin in the blood, giving it a much longer half-life than CJC-1295 without DAC. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$7.70/mg · In stock

Price

$38.50

List

$55.00

Buy 5 mg at Nura Peptide

Price shown uses code thepeptidecatalog at Nura Peptide's checkout (30% off list).

Sold by Nura Peptide as CJC-1295 (With DAC) 5mg. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

CJC-1295 with DAC research vial sold by Nura Peptide as CJC-1295 (With DAC) 5mg
Third-party testedResearch use only
Certificate of AnalysisLot-matched certificates from Nura PeptideView
  • Certificate of Analysis published for every lot
  • Ships from a U.S. fulfillment center, per Nura Peptide
  • Lyophilized powder · laboratory research use only
Research-context information only. CJC-1295 with DAC is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

CJC-1295 with DAC Vial Sizes, Prices & Lots

CJC-1295 with DAC vial sizes, prices and lots at Nura Peptide
SizeListWith our codePer mgAvailability
5 mg$55.00$38.50$7.70In stock

Prices checked today, 6:20 AM CT on Nura Peptide's site, with code thepeptidecatalog applied. Lot data unavailable right now: search Nura Peptide's COA library. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Verified test results

CJC-1295 with DAC Certificate of Analysis

Nura Peptide publishes a third-party certificate for each lot of CJC-1295 (With DAC) 5mg. The figures below are copied from Nura Peptide's current-lot listings (refreshed hourly; hidden if older than 24 hours). Match the lot number on the vial to its certificate.

Nura Peptide's current-lot certificates could not be loaded just now. Search Nura Peptide's COA library by lot number.

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CJC-1295 with DAC Dosing in Clinical Research

Growth Hormone / Longevity

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
2 mg
Reconstitution
2 ml BAC water
Dose
1-2 mg (once or twice weekly)
Timing
PM
Frequency
1-2x per week
Duration
8 weeks on, 8 weeks off
Protocol Notes
The cited short-term studies reported a long half-life and elevated trough GH with preserved pulsatility. Community schedules are not validated clinical regimens.

Why This Dosing Protocol

Why weekly dosing? The DAC modification extends half-life to 6-8 days. A single injection provides sustained GH elevation throughout the week — no need for daily dosing.

Why some prefer no-DAC instead:The sustained GH elevation ("GH bleed") doesn't mimic natural pulsatile patterns. Some researchers believe the peaks and troughs of pulsatile release are more effective for fat loss and recovery. DAC trades physiological signaling for dosing convenience.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator
Popular Stack Protocols1 stack

Commonly paired protocols from the peptide research community. Educational reference only.

CJC-1295 DAC + Ipamorelin

Growth Hormone / Sustained Release
CJC-1295 DAC
Dose
1–2 mg
Vial Size
2 mg
Reconstitution
2 ml BAC water
Ipamorelin
Dose
300 mcg
Vial Size
10 mg
Reconstitution
3 ml BAC water
Timing
CJC DAC: 1–2x per week (PM). Ipamorelin: AM/PM daily.
Frequency
CJC DAC weekly + Ipamorelin 5 on / 2 off
Duration
8 weeks on, 8 weeks off
DAC version provides sustained GH elevation (6–8 day half-life) vs pulsatile release from no-DAC. Ipamorelin daily pulses ride on top of the elevated baseline. Less convenient injection schedule for CJC but more stable GH levels overall. Some prefer no-DAC for more natural pulsatile pattern.

How CJC-1295 with DAC Works

GHRH Analog — Long-Acting (Drug Affinity Complex)

Sequence → Stability → GH Pattern → Outcomes

1
Target

GHRH Receptor on Pituitary Somatotrophs

Same receptor as CJC-1295 (no DAC), Sermorelin, and Tesamorelin. The critical difference is duration of action — the DAC modification causes the peptide to bind albumin in the blood, keeping it active for 6-8 days.

2
Cellular Signal

Sustained cAMP/PKA Activation → Continuous GH Elevation

Rather than triggering discrete GH pulses, the long half-life creates sustained GH elevation(sometimes called "GH bleed"). The pituitary is continuously stimulated rather than pulsed, which differs from natural GH secretion patterns.

3
Systemic Effect

Steady GH/IGF-1 Elevation → Consistent Anabolic Signal

Sustained GH leads to consistently elevated IGF-1 levels. This provides a more constant anabolic environment but lacks the peaks and troughs of natural pulsatile release. Some researchers believe pulsatile patterns are more physiologically effective.

4
What You Notice

Convenience + Steady-State Effects

Weekly dosing convenience is the primary advantage. Effects are similar to other GHRH analogs — sleep, recovery, body composition — but the sustained release pattern may produce different quality of results compared to pulsatile versions. Water retention is more common.

What Makes This Peptide Different

CJC-1295 with DAC is the same modified GRF(1-29) base as CJC-1295 (no DAC), but with a Drug Affinity Complexthat covalently binds to serum albumin. This extends the half-life from ~30 minutes to 6-8 days. The tradeoff: convenience (1-2 injections per week) vs. non-pulsatile GH elevation that doesn't mimic natural patterns. Many prefer the no-DAC version for physiological reasons despite the daily dosing requirement.

GHRH Peptide Comparison

PeptideHalf-LifeGH PatternWhat's Unique
CJC-1295 (no DAC)~30 minNatural pulsatilePulsatile release — more physiological, requires daily dosing
CJC-1295 (DAC)6-8 daysSustained elevationAlbumin binding — weekly dosing, non-pulsatile "GH bleed"
Sermorelin~10-20 minBrief natural pulseNative GHRH(1-29) — most natural, least stable
Tesamorelin~26-38 minReliable pulseFull 44-AA — FDA-approved for visceral fat reduction

CJC-1295 with DAC Clinical Evidence

Two parallel grades per outcome — clinical RCT depth and real-world community adoption. See the Research Overview below for citations and detail.

OutcomeClinical EvidenceCommunity Evidence
Sustained GH and IGF-1 elevation (>1 week)ModerateModerate
Pulsatility preservation under continuous stimulationModerateModerate
Body composition / muscle gainPreliminaryModerate

CJC-1295 with DAC Research Overview

Outcome-by-outcome look at what the evidence actually supports for CJC-1295 with DAC, including human vs. animal study counts and our editorial take on each.

Sustained GH and IGF-1 elevation

Clinical:ModerateCommunity:Moderate

Teichman 2006 (Phase 1, n=24 healthy adults) showed dose-dependent 2-10x GH increases and 1.5-3x IGF-1 increases lasting 6-11 days from a single subcutaneous dose, with multi-dose IGF-1 elevation persisting up to 28 days. Estimated half-life 5.8-8.1 days due to the maleimide DAC group binding albumin. Ionescu 2006 confirmed pulsatility was preserved despite continuous receptor stimulation.

2 human studies · 4 animal studies

Key findings & citations
  • Single-dose GH elevation 2-10x baseline for 6+ days; IGF-1 1.5-3x for 9-11 days.
  • Half-life 5.8-8.1 days enables once-weekly dosing.
  • Pulsatility preserved despite sustained ligand exposure — basal GH up 7.5-fold but rhythm intact.

Our take

Pharmacology is well-characterized at Phase 1. Composition and outcome trials never finished — the program ended for commercial reasons. Treat as a once-weekly sermorelin with extrapolated benefits.

Body composition / muscle gain

Clinical:PreliminaryCommunity:Moderate

ConjuChem advanced CJC-1295 to Phase 2 but development ended before primary outcome publications appeared. Community use rests on the sustained IGF-1 elevation logic plus practitioner reports — there is no peer-reviewed body-composition primary endpoint published.

0 human studies · 4 animal studies

Key findings & citations
  • No published Phase 2 body composition trial.
  • Mechanistic argument: sustained IGF-1 elevation should drive lean mass over months.
  • Clinical reports describe 8-12 week timelines, broadly consistent with sermorelin-class agents.

Our take

Unfinished homework. Effective at moving GH/IGF-1 numbers; whether that translates to a body-composition outcome the FDA would have accepted is unknown.

What CJC-1295 with DAC doesn't do

Claims that current evidence does not support. Worth knowing before you set expectations.

Technical specifications

CJC-1295 with DAC chemical & analytical data

Sold by Nura Peptide as
CJC-1295 (With DAC) 5mg
Receptor targets
GHRH receptor
Backbone length
29 amino acids
Modifications
D-Ala at position 2; DAC (Drug Affinity Complex) for albumin binding
Half-life (clinical PK)
~8 days (weekly dosing)
Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
5 mg
Regulatory status
Research peptide; research-grade vials are not FDA-approved.

CJC-1295 with DAC Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

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Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

11 answers

CJC-1295 with DAC FAQ: Buying, COA, Storage & Research

What are the most common side effects?
Most peptides cause mild injection site reactions, temporary water retention, and possible joint discomfort. CJC-1295 with DAC has minimal impact on cortisol and prolactin levels compared to other GH peptides.
Why do people stack CJC-1295 with Ipamorelin?
This combination works synergistically—CJC-1295 (GHRH pathway) increases the number of cells releasing GH, while Ipamorelin (GHRP pathway) increases GH release per cell. Together they produce stronger results with minimal side effects.
What is DAC and why does it matter?
DAC (Drug Affinity Complex) is a modification that allows CJC-1295 to bind to albumin in the blood. This extends the half-life from ~30 minutes to 6-8 days, meaning weekly injections instead of daily. The tradeoff is that it creates sustained GH elevation rather than natural pulsatile release.
Is CJC-1295 with DAC better than without DAC?
Neither is objectively "better" — they have different use cases. DAC version offers convenience (1-2 injections per week) but causes sustained GH elevation. No-DAC version requires daily dosing but produces more natural pulsatile GH patterns. Many prefer no-DAC for physiological reasons; DAC for simplicity.
What is the typical CJC-1295 DAC dosage?
Common research dosages range from 1-2 mg per week, often as a single weekly injection or split into two doses. Due to the long half-life, more frequent dosing isn't necessary. Some use it with a GHRP like Ipamorelin on non-injection days to add pulsatile release.
Does CJC-1295 DAC cause GH bleed?
Yes, the sustained release creates what's called "GH bleed" — consistently elevated GH rather than natural spikes. Some researchers believe pulsatile release is healthier and more effective. This is a key reason some prefer the no-DAC version despite the inconvenience of daily dosing.
What benefits does CJC-1295 DAC provide?
By elevating GH and IGF-1 levels, CJC-1295 DAC may support fat loss, muscle growth, improved sleep, faster recovery, and anti-aging effects. The sustained release may be particularly effective for consistent IGF-1 elevation. Results develop over weeks to months.
Can CJC-1295 DAC be combined with GHRPs?
Yes, many combine weekly CJC-1295 DAC with daily GHRP injections (like Ipamorelin). This provides baseline sustained GH elevation from the DAC plus natural pulsatile spikes from the GHRP. This approach tries to get benefits of both release patterns.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

CJC-1295 with DAC Studies & Sources

The following peer-reviewed studies and official resources provide additional scientific context for this peptide:

CJC-1295 with DAC Research Articles

dosing

CJC-1295 DAC Dosage Chart: 2mg Twice Weekly

The 8-day half-life changes everything about injection timing. Covers 1-4mg protocols, IGF-1 monitoring, and GHRP stacking.

results

CJC-1295 DAC Results: Week-by-Week Timeline

One injection elevates IGF-1 for over a week — but body composition lags. What the clinical data and community reports show, stage by stage.

side-effects

CJC-1295 DAC Side Effects: Sustained GH Risks

Albumin binding extends half-life to 5-8 days. Water retention, hand tingling, and IGF-1 elevation cluster. Full breakdown.

guides

Buy CJC-1295 with DAC: Compare 3 Vendors, From $47.95

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