Ipamorelin

Lyophilized powder

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that acts on the ghrelin receptor; in early research it raised growth hormone with little effect on cortisol or prolactin. Below: today's vial sizes, prices through our link and the vendor's COA details.

Size

$3.15/mg · lot IPA-062026-1 · 99.78% · In stock

Price

$31.50

List

$45.00

Buy 10 mg at Nura Peptide

Price shown uses code thepeptidecatalog at Nura Peptide's checkout (30% off list).

Sold by Nura Peptide as Ipamorelin 10mg. The Peptide Catalog does not sell peptides; we earn a commission if you buy through this link, at no extra cost to you. For laboratory research use only, not for human or veterinary use. Not FDA-approved. Nothing on this page is medical or dosing advice.

Ipamorelin research vial sold by Nura Peptide as Ipamorelin 10mg
Third-party tested≥99.78% reported purityResearch use only
Certificate of AnalysisLot IPA-062026-1 · 99.78%View
  • Certificate of Analysis published for every lot (Freedom Diagnostics Testing)
  • Current lots report 99.78% purity or higher
  • Ships from a U.S. fulfillment center, per Nura Peptide
  • Lyophilized powder · laboratory research use only
Research-context information only. Ipamorelin is a research peptide. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.

Vial sizes listed by the vendor

Ipamorelin Vial Sizes, Prices & Lots

Ipamorelin vial sizes, prices and lots at Nura Peptide
SizeListWith our codePer mgAvailabilityLot · purity
10 mg$45.00$31.50$3.15In stockIPA-062026-1 · 99.78%

Prices checked today, 6:20 AM CT on Nura Peptide's site, with code thepeptidecatalog applied. Lot data from Nura Peptide's COA page, checked today, 6:26 PM CT. Sizes not re-checked in the last 7 days are hidden. The vendor's checkout is final.

Verified test results

Ipamorelin Certificate of Analysis

Nura Peptide publishes a third-party certificate for each lot of Ipamorelin 10mg. The figures below are copied from Nura Peptide's current-lot listings, checked today, 6:26 PM CT (refreshed hourly; hidden if older than 24 hours). Match the lot number on the vial to its certificate.

All lots on record: Nura Peptide COA library. How to check one: how to verify a peptide COA.

Ipamorelin Dosing in Clinical Research

Growth Hormone / Fat Loss

Educational reference only. Individual responses vary. Consult healthcare provider before use.

Vial Size
10 mg
Reconstitution
3 ml BAC water
Dose
300 mcg per injection (9 units on 1ml syringe)
Timing
AM and/or PM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Protocol Notes
Often stacked with CJC-1295 no DAC for synergistic GH release. Best taken on empty stomach.

Why This Dosing Protocol

Why before bed and/or morning? Ipamorelin amplifies existing GH pulses. The largest natural pulse is ~1 hour after sleep onset, and a smaller one occurs in the early morning. Dosing at these windows maximizes the amplification effect.

Why empty stomach? Same as GHRH peptides — insulin blunts GH release. Fast for 2+ hours before injection.

Why stack with CJC-1295? GHRH (CJC-1295) initiates the GH pulse. GHRP (Ipamorelin) amplifies it. Together, they produce GH pulses 3-5x stronger than either alone. Different receptors, complementary mechanisms.
Full Dosing GuideReconstitution CalculatorCycle Cost Calculator
Popular Stack Protocols4 stacks

Commonly paired protocols from the peptide research community. Educational reference only.

CJC-1295 + Ipamorelin

Growth Hormone / Fat Loss / Anti-Aging
CJC-1295 (no DAC)
Dose
250 mcg
Vial Size
5 mg blend or separate vials
Reconstitution
2 ml BAC water (blend)
Ipamorelin
Dose
250 mcg
Vial Size
5 mg blend or separate vials
Reconstitution
2 ml BAC water (blend)
Timing
AM and/or PM (empty stomach)
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
The most popular GH stack. GHRH (CJC) + GHRP (Ipa) together produce significantly greater GH release than either alone — synergistic amplification of the natural GH pulse. Best taken on empty stomach (2+ hr fast). Many vendors sell this as a pre-mixed blend vial (5mg/5mg).

CJC-1295 DAC + Ipamorelin

Growth Hormone / Sustained Release
CJC-1295 DAC
Dose
1–2 mg
Vial Size
2 mg
Reconstitution
2 ml BAC water
Ipamorelin
Dose
300 mcg
Vial Size
10 mg
Reconstitution
3 ml BAC water
Timing
CJC DAC: 1–2x per week (PM). Ipamorelin: AM/PM daily.
Frequency
CJC DAC weekly + Ipamorelin 5 on / 2 off
Duration
8 weeks on, 8 weeks off
DAC version provides sustained GH elevation (6–8 day half-life) vs pulsatile release from no-DAC. Ipamorelin daily pulses ride on top of the elevated baseline. Less convenient injection schedule for CJC but more stable GH levels overall. Some prefer no-DAC for more natural pulsatile pattern.

Sermorelin + Ipamorelin

Growth Hormone / Anti-Aging
Sermorelin
Dose
200–300 mcg
Vial Size
5 mg
Reconstitution
2.5 ml BAC water
Ipamorelin
Dose
200–300 mcg
Vial Size
10 mg
Reconstitution
3 ml BAC water
Timing
PM (before bed, empty stomach)
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Same GHRH + GHRP synergy as CJC/Ipa but using Sermorelin as the GHRH component. Sermorelin is a native GHRH fragment with FDA history (previously approved as Geref). Some clinics prefer this stack for a more conservative, well-studied approach.

Ipamorelin + GHRP-2

Maximum Growth Hormone Release
Ipamorelin
Dose
200 mcg
Vial Size
10 mg
Reconstitution
3 ml BAC water
GHRP-2
Dose
100–200 mcg
Vial Size
5 mg
Reconstitution
2.5 ml BAC water
Timing
AM and/or PM (empty stomach)
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Double GHRP stack for aggressive GH output. GHRP-2 is more potent but has more side effects (cortisol, prolactin, appetite). Ipamorelin is cleaner. Together they hit ghrelin receptors through slightly different binding profiles. For advanced users who want maximum GH secretion. Monitor appetite and cortisol.

How Ipamorelin Works

GHRP (Growth Hormone Releasing Peptide) — Ghrelin Receptor Agonist

Receptor → GH Secretion → Systemic Effects → Outcomes

1
Target

GHS-R1a (Ghrelin/Growth Hormone Secretagogue Receptor)

Unlike GHRH peptides (CJC-1295, Sermorelin), Ipamorelin works through a completely different pathway — the ghrelin receptor. This is why the two classes are often stacked together: different receptors, complementary signals.

2
Cellular Signal

IP3/DAG Pathway → Amplified GH Pulse

Ghrelin receptor activation uses the IP3/DAG signaling cascade (distinct from GHRH's cAMP/PKA pathway). This amplifies the magnitude of each GH pulse and makes the pituitary more responsive to incoming GHRH signals. Ipamorelin is uniquely selective — it triggers GH release without significantly increasing cortisol, prolactin, or appetite.

3
Systemic Effect

Amplified GH Pulses → Enhanced Recovery & Body Composition

By amplifying GH pulse magnitude (rather than initiating pulses like GHRH), Ipamorelin boosts IGF-1 levels with minimal hormonal side effects. The selectivity means no cortisol spikes, no prolactin issues, and minimal hunger increase — making it suitable for extended protocols.

4
What You Notice

Better Sleep → Steady Recovery → Gradual Recomp

Improved sleep quality, reduced joint discomfort, and gradual body composition improvements. Effects are mild but consistent. Best results when combined with a GHRH peptide — alone, Ipamorelin amplifies existing GH signals but doesn't initiate new ones.

What Makes This Peptide Different

Ipamorelin is the most selective GHRP available. While GHRP-2 and GHRP-6 also trigger GH release through the ghrelin receptor, they come with cortisol elevation, prolactin increase, and significant hunger. Ipamorelin avoids all of these, making it the safest GHRP for long-term use and the ideal stacking partner for GHRH peptides.

Sequence → Why It Matters

Ipamorelin is a synthetic pentapeptide (5 amino acids) with non-standard residues:

1
Aib (aminoisobutyric acid) at position 1
Conformational constraint — helps the peptide maintain its active shape
2
D-2-Nal and D-Phe (D-amino acids)
Protease resistance + receptor selectivity — why it avoids cortisol/prolactin effects
3
Only 5 amino acids total
One of the smallest GH-releasing peptides — compact but highly selective

So what? The non-standard amino acids are specifically chosen for selectivity. Other GHRPs use similar ghrelin receptor activation but trigger broader hormonal responses. Ipamorelin's sequence engineering achieves GH release while avoiding the cortisol, prolactin, and appetite side effects that make other GHRPs harder to tolerate long-term.

Ipamorelin Clinical Evidence

Two parallel grades per outcome — clinical RCT depth and real-world community adoption. See the Research Overview below for citations and detail.

OutcomeClinical EvidenceCommunity Evidence
Selective GH release (pre-clinical)StrongStrong
Bone formation in animal modelsModerateStrong
Postoperative ileus (Phase 2b)WeakStrong
Body composition / muscle gain in healthy adultsPreliminaryStrong

Ipamorelin Research Overview

Outcome-by-outcome look at what the evidence actually supports for Ipamorelin, including human vs. animal study counts and our editorial take on each.

Selective GH release

Clinical:StrongCommunity:Strong

Raun 1998 showed that ipamorelin elicits GHRP-style GH release in rats and swine without raising ACTH, cortisol, or prolactin even at doses >200x the GH ED50 — a selectivity profile no other GHRP shares. This is the foundational mechanistic claim for ipamorelin's modern positioning as a 'cleaner' GHRP.

0 human studies · 8 animal studies

Key findings & citations
  • GH release potency in rats/swine comparable to GHRP-6 but without cortisol or prolactin elevation.
  • Selectivity holds at doses >200x the ED50 for GH.
  • Mechanism: GHS-R1a agonism (ghrelin receptor) without off-target H1/H2 receptor activity.

Our take

The cleanest GHRP we have, and the reason ipamorelin became the default partner for GHRH analogs in modern stacks.

Bone formation

Clinical:ModerateCommunity:Strong

Svensson 2000 and follow-up rodent studies show ipamorelin increases bone mineral content in adult female rats and counteracts glucocorticoid-induced bone loss in additional rat models. No published human bone trial — the bone story is mechanistically credible but rodent-only.

0 human studies · 6 animal studies

Key findings & citations
  • Increases bone mineral content in adult female rats over 12 weeks.
  • Counteracts glucocorticoid-induced bone formation suppression in rats.
  • No human trial has measured BMD endpoints with ipamorelin monotherapy.

Our take

Promising preclinical signal. Anyone using ipamorelin specifically for osteoporosis prevention is ahead of the data.

Body composition / muscle gain in healthy adults

Clinical:PreliminaryCommunity:Strong

Despite extremely widespread community use as part of CJC-1295 + ipamorelin stacks, there is no published human RCT of ipamorelin in healthy adults with body composition as a primary endpoint. The clinical data lives in postoperative ileus (Helsinn/Lupin's Phase 2b POI program), not muscle gain.

0 human studies · 4 animal studies

Key findings & citations
  • Zero published human composition RCTs of ipamorelin monotherapy.
  • Phase 2b POI program (Helsinn) explored bowel-motility recovery, not body composition.
  • All composition claims extrapolate from MK-677, sermorelin, and GHRP-6 literature.

Our take

Real GH pulses, no published human composition data. Use it because the GH pulses are real, not because there's a randomized trial saying it builds muscle.

What Ipamorelin doesn't do

Claims that current evidence does not support. Worth knowing before you set expectations.

Technical specifications

Ipamorelin chemical & analytical data

Sold by Nura Peptide as
Ipamorelin 10mg
Receptor targets
GHSR-1a (ghrelin receptor)
Backbone length
5 amino acids
Modifications
C-terminal amidation; Aib at position 2; D-2-Nal at position 3
Half-life (clinical PK)
~2 hours
Form
Lyophilized (freeze-dried) powder in a sealed vial
Presentation
10 mg
Purity on current lots (COA)
99.78%
Testing laboratory
Freedom Diagnostics Testing
Regulatory status
Research peptide; research-grade vials are not FDA-approved.

Ipamorelin Reconstitution Calculator

Dilution math and unit conversions. Prefilled using a common vial size for this peptide.

Open calculator

Storage & Handling

Storage at a glance

Proper storage temperatures, shelf life, reconstitution best practices, and travel tips for lyophilized and reconstituted peptides.

Powder: Freezer
1+ year at -20°C
Reconstituted: Fridge
4 weeks max at 2-8°C
View Complete Storage Guide

Handling specifics

Educational overview on storage, labeling, and traceability considerations for lab environments. Consult primary literature and vendor documentation for specifics.

Powder storage (very stable)
  • Freezer (-20°C): 1+ year
  • Refrigerator (2-8°C): 1-3 months
  • Room temperature: 2-3 weeks (emergency only)
Reconstituted storage (fragile)
  • MUST refrigerate at 2-8°C
  • 4-week maximum shelf life
  • NEVER freeze after reconstitution
  • Use bacteriostatic water for multi-dose

11 answers

Ipamorelin FAQ: Buying, COA, Storage & Research

What makes Ipamorelin different from other GH peptides?
Ipamorelin is one of the most selective growth hormone releasing peptides (GHRPs). Unlike other GHRPs like GHRP-6 or GHRP-2, it stimulates GH release without significantly increasing cortisol, prolactin, or appetite. This selectivity makes it one of the mildest options with fewer side effects.
Why is Ipamorelin often stacked with CJC-1295?
This combination activates two complementary pathways: CJC-1295 works through the GHRH receptor to increase the number of pituitary cells releasing GH, while Ipamorelin works through the ghrelin receptor to increase GH output per cell. Together, they produce a synergistic effect greater than either peptide alone, often called the "CJC/Ipa stack."
What are the most common side effects?
Ipamorelin is considered one of the gentlest GH peptides. Possible side effects include mild headache, water retention, and tingling in extremities. Unlike GHRP-6, it typically does not cause significant hunger increases. Injection site reactions may occur but are usually minor and temporary.
How does Ipamorelin compare to GHRP-6 and GHRP-2?
Ipamorelin is more selective than both GHRP-6 and GHRP-2. GHRP-6 causes strong hunger increases and can raise cortisol. GHRP-2 is more potent but also affects cortisol and prolactin more. Ipamorelin provides a cleaner GH release with minimal impact on other hormones, making it preferred for those prioritizing side effect profile over raw potency.
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (5 amino acids) that stimulates growth hormone release by mimicking ghrelin at the pituitary gland. It was developed specifically to be selective for GH release without affecting other hormones. This makes it popular for those wanting GH benefits with minimal side effects.
What is the typical Ipamorelin dosage?
A common research dosage is 300 mcg per injection, administered AM and/or PM on a 5 days on, 2 days off schedule (8 weeks on, 8 weeks off). Best taken on an empty stomach. It's often combined with a GHRH like CJC-1295 no DAC for enhanced effects.
What benefits does Ipamorelin provide?
By elevating GH levels, Ipamorelin may support fat loss, lean muscle growth, improved sleep quality, faster recovery, enhanced skin health, and anti-aging effects. Many users report improved sleep as an early benefit. Results develop gradually over weeks to months of consistent use.
Does Ipamorelin cause hunger like GHRP-6?
No, Ipamorelin's selectivity means it doesn't significantly increase appetite. While it does work on ghrelin receptors, its effect on hunger is minimal compared to GHRP-6 or even GHRP-2. This makes it suitable for those on calorie-restricted diets or who want to avoid increased appetite.
How long does reconstituted peptide last?
Once mixed with bacteriostatic water, peptides remain stable for up to 4 weeks when refrigerated at 2-8°C (36-46°F). Unopened powder can last 1+ year in the freezer. Get our complete Storage & Travel Guide.
Is this peptide legal to purchase?
Peptides sold "for research purposes only" are legal to purchase in the US, but are not FDA-approved for human use outside of specific medical applications. Always consult a healthcare provider before use.
New to peptides?
Take our Peptide Match tool to find the best peptide for your goals. You can also read our Complete Guide to Peptides to learn the basics.

Ipamorelin Studies & Sources

The following peer-reviewed studies and official resources provide additional scientific context for this peptide:

Ipamorelin Research Articles

guides

Tesamorelin + Ipamorelin (Tesa/Ipa) Blend Dosage

Tesa/Ipa pairs tesamorelin, a GHRH analog, with ipamorelin, a ghrelin-receptor agonist. What each does, how they differ, and the 10mg/3mg doses reported.

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Ipamorelin Dosage Chart: 300mcg AM/PM, 5-On/2-Off

Once vs twice daily isn't just about cost — GH pulse patterns differ. Covers 300mcg protocol, fasted timing, and 5-on/2-off cycling.

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CJC-1295 + Ipamorelin: 250mcg/250mcg Stack Dosage

The synergy only works if you time both peptides right. Covers the 5mg/5mg blend protocol, reconstitution, and 8-week cycling.

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Buy Ipamorelin: Compare 5 Vendors, From $35

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